Here is my current regimen, updated each time I change something:
Upon waking up at 6:30am & before sending kids to school:
Half of all Vitamin B (3,6,12, biotin)
Calcium Pyruvate 500mg in a capsule.
Cold Jiaogulan tea all day instead of water as much as possible.
Coffee with 1 tps sugar and milk
Bread and butter, small Danish if not too sweet, or american breakfast.
I also take Glucosamine once a week and Pro-biotic (on Sundays only)
2 tbsp coconut oil
Sometimes I skip the breakfast (except the coffee) and I’ll take the protein shake sooner.
Whey isolate proteins shake, no more than 2 scoops (32gr) with added:
Valine 2000 mg
DHEA 10 mg
Pregnenolone 10 mg (testing 20mg)
Sometime I add half a scoop of vegan protein shake if feeling hungry. It adds extra good aminos without adding extra Cysteine which can make me feel nauseous.
Pine Pollen with DMSO, 1 pea size rubbed on both forearms. (see below)
Before Lunch at Noon
Other half of all vitamin B
Gelatin 5gr in hot water with beef stock (Soon to be replaced by collagen peptides, 2-3 gr.)
Lunch at Noon:
Rib eye Steak 250-350 gr (or some other fat cut of steak), saturated fat and kale 250 gr.
After 6 months of this diet, I’m more flexible. As long as it’s low carbs, high saturated fat and high protein it’s Ok. Fat can be butter, ghee, lard of tallow.
Right After Lunch:
5-HTP 50/100mg (testing)
Tyrosine 250/500mg (testing)
L-Dopa 175/350mg (testing)
Vitamin A 10000 IU (currently at 25000 IU until I can find 10000 IU pills)
Vitamin D3 10000 IU
Multi-vitamins for men or some natural multi-vitamins
Calcium Pyruvate 400mg (put in a small capsule. It taste bad and does not dissolve easily)
Will test, right after lunch:
Vitamin K2 5 mcg (Maybe increase to 10 mcg. 45000 mcg is upper safe limit but effects start to be felt at 5mcg and higher doses may mess up your joints. People have had bad effects with this one. Better keep it low)
Before exercise or sex, either around 11am or 2-3pm:
Arginine suite (L-Arginine 1000mg, Arginine AKG 500mg, L-Citrulline 500mg, L-Ornithine 500mg). I don’t always take it.
I do at least some exercise every day. Exercise is mostly resistance training but also some cardio.
Between Noon to 5 pm:
200 ml of electrolyte mix (see below) with 50-100 ml of soda water (plain carbonated water with bubbles).
I add Carnitine Tartrate 1000 mg with Betaine HCL 400mg in the electrolyte mix as they
re all sour. Its delicious. Too bad I can take only one glass per day ! (more would throw my electrolytes out of balance)
Whey isolate protein shake 2 scoops (32 gr) (if hungry) Sometime with added 1/2 scoop vegan protein shake if hungry.
Dinner before 6pm:
Either same as Lunch or something lighter like a soup made with bone broth, some cheese and some raw veggies like cabbage, cucumbers or celery. Most important is I’m finish eating before 6pm so I can take my sleeping pills on an empty stomach.
Also I drink the least liquids possible after 6pm so I don’t have to wake up and pee at night. That really messes up my night and the next day.
3 mg Clonazepam (sleeping pill)
2.5 mg Hydroxyzine (anti-histamine)
Before sleep at 9;30pm:
B3 (niacinamide) 30 mg
Slow Release Melatonin 5mg
1/3 a cup of warm milk with 1/2 tsp honey and Inusitol (Vitamin B8) 3000mg
a slice of cheese. (this is to prevent Cortisol Spike during the night)
I keep 3000mg of Inusitol, a glass, a spoon and some water next to the bed in case I wake up during the night. If I do, I’ll take the Inusitol and go back to sleep.
Sleep at 9:30/10pm, always wake up at 6:30/7am even on holidays.
I will test getting up after waking up if I slept at least 6 hours, just to see if That’s my body telling me I slept enough.
I can take Theanine 200mg a second time during the day or in the evening. it’s like an aspirin for stress. (I wouldn’t take more than 2 doses a day)
Careful with high doses of Theanine with high doses of Arginine as it can cause drop in blood pressure.
Electrolyte mix :
In a 1.5 liter bottle: 10 gr magnesium chloride, 5 gr potassium chloride, 150 ml lemon juice or 8 gr citric acid, natural orange/lemon flavor, fill with water to the rim.
Pine Pollen with DMSO: I mixed 1 ounce of DMSO and 1 scoop (5gr) of Pine Pollen. That lasts me for months as I need only apply 1 pea size (or 2) to one of my forearm, and rub both forearms together to spread it over the veins. It goes straight to the blood, ergo the much smaller dose.
I’m soon to introduce new supplements. I’m now studying Adrenalin Fatigue as I think it’s the cause of waking up during the night (If not the Orexin complex). I will also check my testosterone / estrogen ratio to make sure it’s in line.
Some notes on tolerance for Serotonin and Dopamine
L-Dopa can induce tolerance. According to a clinical study on Alzheimer subjects, It takes 5 years, at 350mg per day to develop tolerance and dosage needs to be increased. Good news, if a patient takes an L-Dopa holiday of 7 days after 5 years, he can then decrease the dose by 30-50% for the next 3 years before needing another holiday. So to avoid tolerance, we can either take a one week holiday every year or two, or maybe cycling the drug will do it (but I do’t know if stopping only one day per week enables the receptors to clear out. it’s just theory)
For 5-HTP, it’s dangerous if combined with:
Selective serotonin reuptake inhibitor(SSRI) (One guy on this forum got sick by combining both.)
Serotonin norepinephrine reuptake inhibitor(SNRI)
Monoamine oxidase inhibitor(MAOI)
Tricyclic antidepressants (TCAs)
St. John’s worth
So be careful. Some people here are on SSRI, SNRI or TCAs. Also beware of 5-HTP and St-John’s Worth combination. (should I mention taking ecstasy or cocaine is not a good idea if you’ve got PFS ?)
Recommended dosage of 5-HTP goes from 100mg to 900mg a day, and according to another study administration of 5-HTP alone depletes catecholamines (dopamine, norepinephrine, and epinephrine, the later two being produced from dopamine). So it should be taken along with L-Dopa. Morning coffee also increase catecholamines production.
Here’s the chemistry:
5-HTP may deplete dopamine.
l-tryptophan may deplete dopamine.
l-dopa may deplete serotonin,
l-dopa may deplete l-tryptophan.
l-dopa may deplete l-tyrosine.
l-dopa may deplete sulfur amino acids.
l-tyrosine may deplete serotonin.
l-tyrosine may deplete 5-HTP.
l-tyrosine may deplete sulfur amino acids.
Sulfur amino acids may deplete dopamine.
Sulfur amino acids may deplete serotonin.
Study group were given:
5-HTP daily dosing values > 0 to 2,400 mg per day.
l-tyrosine daily dosing values > 0 to 14,000 mg per day.
l-dopa daily dosing values > 0 to 2,100 mg per day.
It seems that to avoid depletion, not much is needed:
5-HTP dosing value of 2,400 mg per day with an l-dopa dosing value of 30 mg per day is required for proper balance, or 25 mg per day of 5-HTP with 2,100 mg of l-dopa will be in proper balance.
I’ve seen nothing bad on serotonin tolerance, even at higher dose, unless it’s taken without L-Tyrosine or L-Dopa, or if taken in combination with what’s listed above as dangerous interaction.
To answer questions left open by all this data, Depletion of L-Tyrosine is unlikely if you eat meat (I get 9000 mg a day in my 2 steaks) and tolerance is obviously out of the question as it’s a common amino acid found in food. Sulfur amino acids are common is food, especially meat, and you get them all in a protein shake. I also think depletion or tolerance is not an issue unless you’re on a restrictive diet (like you’re a virtuous vegan with deficiencies all over the place)
So to conclude on this, 5-HTP 100mg / 200mg, taken along L-Dopa 350mg / 700mg and L-Tyrosine 500 mg / 1000mg, all 3 taken daily, should not induce tolerance except for L-Dopa which may induce tolerance after 3-5 years. A one week L-Dopa holiday per year (or reducing L-Dopa to 25mg per day for 1 week while still taking 5-HTP) should avoid tolerance.
Here’s what I think of the amino acids I tested:
Well, I’ll start by those who have a good effects:
5-HTP 100mg along with L-Tyrosine 500mg and L-Dopa 350mg first thing in the morning.
This clears away the brain fog, prevent depression and makes me feel confident. It also put me in a good mood and I’m motivated to begin the day. My best amino acids.
For a time, I took a second set at noon. Feels great, maybe too much, and it makes it harder to sleep at night.
Theanine 200mg: This one works on GABA, serotonin and dopamine. I use it in case of anxiety or stress in the day time but it doesn’t feel good before bed time. I take it with coffee as it creates a synergy with caffeine and prevent a caffeine rush (cortisol spike). It’s mellow, but energetic at the same time. good for concentration. At other time I consider it as an anxiety aspirin.
L-Valine 2000mg. I take this one in an effort to restore sexual sensitivity. Sensitivity is increasing but it’s over a long period of time (months) and I can’t know for sure if Valine is responsible. It’s one of the one BCAA that has an effect on the mind, connecting it to the muscle, among other effects.
DHEA 10mg. This is a precursor to both testosterone and estrogen. it raises both. The pills are 100mg, which is way too much (and feels bad) but at 10mg, I get a good effect at boosting testosterone (I deal with estrogen with other aminos below). This one can be dangerous and make people worst. use with caution and in small dose. It has to be tapered off.
Pregnenolone 10mg: Precursor to most hormones. When I take it, i feel calm and strong. It kinda stabilize me deep down inside. In can be transformed onto whatever hormone the body needs (almost). I once took up to 400mg a day ! I was feeling hype and on top of the world. After a while, I started destabilizing so I tapered off to 10mg. This one also can be dangerous and make people worst. use with caution and in small dose. It has to be tapered off.
DLPA 500mg. It’s the cousin of L-Tyrosine and both are precursors to regulating dopamine. I can’t say I’ve seen a difference taking it.
Pine Pollen in DMSO. DMSO can be mixed with both water and oil, and it extract what is soluble in both. Putting the pine pollen in DMSO and applying a pea size to my forearm (and spreading it) makes all pine pollen androgen go directly to the blood. I once put 1/2 tea spoon and I felt like taking two Testocaps. A real testosterone rush. It made me aggressive so I reduce to a pea size amount. (this one prevents prostate cancer. It’s an adaptogen.
Choline 500mg: This one does 3 cool things. It cleans the liver of fat (I’m on a high saturated fat diet), it’s creates the neuro-transmitter acetyl-Choline which among other things, regulates the vagus nerve (and therefore has an effect on the guts) and it methylate estrogen and get rid of the excess.
Inusito 500mgl: It’s actually vitamin B8. It goes well with Choline as it also cleans the liver from fat, but Choline is a stimulant and B8 is a relaxant. I’m now testing it as a sleep supplement, at 2-4 gr before sleep. So far so good.
Betaine 400mg. Along with Choline, it methylate estrogen and get rid of the excess. It does other cool stuff like greatly helping with digestion, heart health and people use it for better athletic performance. It helps in improving sleep by easing digestion.
Glutathione 250mg. The body’s master anti-oxidant. We can create it with Cysteine (which makes me nauseous if I take too much) so I take Glutathione directly. I’d be lying if I said I feel super anti-oxidized. But it decreases inflammation so that can’t be bad.
Collagen peptide 5 gr. I take this after a fast, to fix leaky guts, to prevent food allergies and reduce inflammation. It also fixes joints. Great supplement. People have had bad effect from this. I took up to 30 gr. a day and was fine but i keep it to no more than 5 gr now.
Of course, there’s the whole vitamin B complex, which is of use against anxiety. B6 and B12 are needed to convert serotonin into melatonin. (along with calcium, magnesium and zinc. but all in small amounts, like 1/10th of a normal commercial dose)
I’m now trying Calcium Pyruvate 1000mg as a source of both components. Calcium should be taken in the morning, it’s a stimulant, but a small dose before sleep (like 25mg) helps with melatonin. Pyruvate promotes the Orexin complex which regulate the circadian rhythm. Makes you awake in the day and sleep at night. It regulates the production of melatonin. Again so far so good. Worst case scenario, I’m just taking a calcium supplement at low dose.
Carnitine Tartrate 1000mg. Helps build muscle when doing resistance training and creates more estrogen receptors. Aas resistance training boost 5 alpha reductase, I think this one contributes. I take it to alleviate sexual symptoms. I don’t know if it works. I do have a six pack, nice pecs and nice shoulders, and sexually I’ almost 100% except for a lower sex drive (maybe it’s pfs, maybe it’s because I’m 50, maybe it’s because I took the red pill and I have less interests in women. I don’t know)
The Arginine suite: L-Arginine 500mg, Arginine AKG 500mg, L-Citruline 500mg, L-Ornithine 500mg.
basically gets rid of ammonia in the body, creates nitric oxide, is good for erections and helps sleep by clearing out sulfur dioxide (which can cause insomnia and headache) I take it before training as it eliminates toxins from the muscle as we train. Also good before sex, it’s a natural, less potent Viagra.
Melatonin. It helps me sleep. Before I was taking an anti-depressor (Agomelatin) which interacted with melatonin so I couldn’t take this supplement but now I can. I never saw any affects from Agomelatin, except on my wallet: it’s expensive.
What didn’t work or had negative effects:
GABA. It’s suppose to help with anxiety but it interacts with the benzodiazepine I take for sleeping. So it’s bad for me, maybe good for someone that takes no drugs acting on the GABA receptors.
Calm Aid. Silexan (lavender oil). It doubles down on my benzodiazepine and knock me out for the night. it’s like a double dose. However, it’s estrogenic and make all sexual symptoms worst. Not for me.
Fish oil. Omega 3-6-9. For some reason, I feel bad taking it. I think it’s an 5ari and that would be why. To be honest, if it feels bad, I don’t waste time searching why. I just flush it.
Taurine. I had great hope for this one. In the absance of allopregnanolone, it the back up regulator of GABA receptors. But it makes me feel bad. Either because my GABA R are messed up, or because it interracts with the benzodiazepine. Aalso not for me.
Tryptophan. People have good effects from this, not me. If I take it before sleep, it’s a ticket for insomnia. For some reason I don’t get, 5-HTP works better for me (but in the daytime)
Glycine: Another one that was supposed to help but never did anything I can feel. It’s suppose to fix the guts, although collagen is better in my opinion. So I take it or not, no difference.
Glutamine. Tried it in the day time, before bed, never saw a difference. It is the most common amino acid in the body (makes up 30 or 40% of all aminos in the body, I can’t remember). I take it as a supplement to create muscle. It surely helps but I can’t feel it.
That’s all the time I have today.
Next time, I’ll write some about vitamins, minerals and herbs.
I wish the best to you all.
Update: Inusitol in a separate form (without Choline), Betaine and Calcium Pyruvate are new additions to my regimen. I still don’t know if and How I will add them permanently.
Yesterday I had a bad night. Possibly because I overslept by 2 hours on the previous night (it always makes it difficult on the next night when I oversleep) or possibly because of Calcium Pyruvate, Calcium being a stimulant and Pyruvate boosting the Orexin complex (the awakeness hormone). Still need more testing to ascertain it’s effects.
Betaine HCL, especially at lower doses like I’m taking, does not seem to be detrimental.
Inusitol (B8) 2000mg is surprisingly good. If it wasn’t for having to get up and pee, I would have had a wonderful night. I woke up (to pee) feeling amazingly groggy and it went away within 5 minutes. After I couldn’t sleep for the rest of the night. I’ve read taking another 2000mg after waking up would fix this. I’ll test it.
And here how the experiment started:
So I’m starting a new experiment with aminos. My aim is to improve all pfs symptoms.
In my morning shake, half vegan and half whey protein isolate, I’m putting these extra aminos:
Update: 30 minutes after that shake, I feel sleepy. It must be the 5-HTP. I’ll do some cardio to wake me up.
I also took an extra 500mg of Tyrosine (or had the intention of taking it anyway. Short term memory is still not good and I can’t know for sure if I took it or not)
30 minutes Before lunch I took
L-Arginine, L-arginine AKG, L-Citruline, 500mg each in 1 pill.
I had steak and Kale for lunch, Kale being taken for it DIM content in an effort to balance the extra estrogen DHEA might produce.
In the afternoon, I felt energized and very motivated. I started doing some weight lifting and cardio, and in the end, I just couldn’t stay home and went to the swimming pool with one of my son.
My mind is clear, I feel happy, strong and confident.
We then went to a restaurant and I had spaghetti and meatball with garlic bread. I’m noting this here and it’s relevant because 4 months ago carbs used to cause me anxiety, panic attack, speech slur, confusion, depression and extreme weakness (can’t stand up kinda weakness). I had none of that. As noted under my
Collagen experiment The use of Collagen it’s unclear if the changes came from collagen or from the ketogenic / carnivore diet (or maybe simply the passage of time if I could be that lucky)
Now I’ll do some more weight lifting to burn out those dirty carbs.
Before sleep, I will take:
Gaba (150mg) (from a 750mg pill to avoid vivid dreams)
Glycine (500 mg) (cut in half because I took 2.5gr of gelatin which contains 750mg of glycine)
Glutamine (2.5 gr) (cut in half, Protein shake contains Glutamine)
That’s a lot of different aminos, Later on, I’ll be more selective and try and sort out which one works best.