https://www.sciencedirect.com/science/article/abs/pii/S1743609521005130
The Baylor epigenetic Abstract is online.
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So this is the famous āBaylor Studyā the community has been waiting for?
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1400 genes over expressed and 2400 under expressedā¦
This is the abstractā¦need detailsā¦
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I just logged in through the university where I work to download the entire pdf but it says they donāt sub to the content so I guess somebodyās gonna have to pay for it
It doesnāt sound like good news.
Iāll wait for someone more knowledgeable to chime and possibly explain it to us, but from what I understand we can probably say goodbye to the perspective of a one-fits-all ātherapyā.
Sounds bad to me even if it were a few hundred genes it would be harder to find a therapeutic target but Iām not that knowledgeable and what I can see of it is says cannot establish causalityā¦
3.800 total genes with significantly altered expression.
Donāt humans have just 25-30.000?
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I believe you are correct but they are saying they donāt have test of the subjects ābeforeā they took finasteride to compareā¦
What do u need then? 100 people and run this complete gene expression analysis on them allā¦Then give them all finasteride and see how many developers pfs and then run the same test on the all to compare again? My guess is about 8 to 10 people will develop the disease out of 100.
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Iām no expert by any means, but what are the chances we had all these alteration even before taking Fin?
Doesnāt sound very realistic.
Youāre telling meā¦no difference in trinucletide repeats or serum levels between themā¦
Sounds like the entire symptomolgy depends on which and how many genes are altered.
ā¦meaning? Is it good news?
I would think so but most have known that blood levels of hormones were not a factor much.
Iād love to know more about the variance in gene over/underexpression among patients.
Treatment with Accutane read similar. Hard to believe its already been two years since I posted this.
All significantly changed genes after 8 weeks isotretinoin therapy
I remember this post,
āI suspect Baylor will find something similar. It will then be a question of āwhere to from here?ā
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Yepā¦funny thing is I also took Accutane almost 30 years ago but not for long and had blood test monitoringā¦
I didnāt have problems nor the first time on finasteride I guess it went back to normal.
Wait a second ā¦
So the alteration in gene expression doesnāt necessarily lead to the development of symptoms, right?
Thatās where the epigenetic theory comes inā¦why wonāt it go back to normal?
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Regardless of genes expression going back to normal or not ā¦
I mean, from what @guitarman01 posted it doesnāt seem like a gene alteration necessarily leads to symptoms.
It would depend on which onesā¦
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Why is the rest of the information hidden behind a paywall?