Mohit Khera - Baylor Study - Genetic and epigenetic studies on post-finasteride syndrome patients. - Relase in Summer 2021?

I wanna know for sure if anyone on GOOD authority said there will be nothing for certain in the way of a treatment or cure

If not? People gotta STOP saying that on here

I completely understand the despair, unfortunately

But some visit here for help or guidance and instead get “you’re fucked, deal with it”

How can u offer guidance it’s extremely dangerous as some people’s advice has worsened them considerably even causing suicide as what helps some has hurt others…

I wouldn’t in good conscience advise anyone on here in terms of trying “treatments” because there isn’t any…

Guidance, reassurance, moral support
It’s a lot better than negativity
Just so someone feels not alone is what I meant

And I’ve never advised anyone on treatments except for a few benign supplements like magnesium for insomnia even though I’ve dabbled in some other treatments
I wouldn’t in good conscience tell anyone to take something especially if they aren’t comfortable with it

But moral support? Absolutely

Yea that’s great :+1: I wouldn’t take any supplements awor simply took milk thistle and worsened considerably…to the point he never recovered back to his previous baseline…

No one knows the future but just being realistic I wouldn’t set myself up thinking baylor would be a cure or something like that…

A sudden advancement might be detailed genes that are damaged that could tie in to other issues like the prostate cancer issue I mentioned earlier…A guess is its genes that are highly adaptable that control this so prostate cancer still grows without the androgens…It is like the opposite has happened to us that the expression has changed or adapted that we are incredibly insensitive to androgens…

Nobody knows. It’s as simple as that. We don’t know the nature of the issue. Nobody will ever say nothing can be done even if we did know what it was, as the state of the art is always advancing and the future may hold technologies which might be able to assist us.

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@holyhead some do improve with time while a very unlucky few of us unfortunately get progressively worse. What’s your story “sorry couldn’t find it” and what are your sides / current situation

I want to get a penile implant but I’m worried that I might regret it if Baylor finds something significant that could lead to a cure, that’s why I want to see it first, so that I have some peace of mind when I decide for an implant.

How bad the situation may seem, I think the best thing to do is to wait for the study to be published. Since it’s already been submitted and in peer review, my best guess is that it probably would be out this year. After that we can see if something significant has been discovered. No need to make the situation worse then it already is.

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Awor in 2009

The bottom line to all this is: Our problem is likely to be at the molecular level, an area which is still relatively poorly understood by basic science. In order to get our problem onto the map (an get research going), we need to get something published. As far as I can tell, it is not realistic that a cure will be found to our problem within a useful time frame – even once research has started. However, it is realistic that our bodies can heal themselves (at least in some cases). We must support our bodies the best we can in the process. Given the assumption of this problem, it is also not realistic that a simple doctor has any real chance of helping us. A regular doctor (as opposed to a scientist) is governed by the boundaries of basic science. Even worse, he/she is governed by commercialized solutions (i.e. pharma products) resulting from basic science. So if the basic scientists are still trying to figure out what’s going on at the molecular level, we can’t expect a simple doctor to be able to solve this. Most of us that have been to see various “specialists”, without real results to show for, probably have realized this
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I think we can be a little more optimistic today. Awor’s statement was from before CRISPR was invented. The advent of CRISPR is amazing. Its utilisation and further development are progressing at a rapid speed. Clinical application has already started. There is a lot of money behind it. It’s been coupled with the use of mRNA technologies. And, of course, with mRNA delivering the first COVID-19 vaccinations, this is also all the rage. It’s a fortunate development for us.

Obviously, this means very little if we don’t know what the problem is. There is a lot of work for us to do to understand our condition and identify therapeutic targets. And, obviously, there is also a lot of progress to make for science for genome/epigenome editing or similar interventions to become “normal”. But compared to 2009, technologies that may help us in the future are actually under development and actively being tested in much more simple conditions. That’s a positive, even if it is still a long shot.

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There is a sick (hypersensitiv) Feedback from lowerd Androgen Level to genregulation in some men. Most of them connected to Depression.

How’s Awor doing by the way?

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https://www.nature.com/articles/d41586-021-01776-4

Something like this.

@axolotl can you tell us about the perspectives from CRISPR in pfs treatment? Can you Cut DNA methylated Androgen Rezeptor Gen an Bring in non methylated DNA coding Androgen Receptor again

So we have all to wait with suicide or Penis prothesis, to the CRISPR Therapie

I have no sexual side effects nor is anything wrong with my penis…It’s fine.

I really don’t understand the productive purpose in digging up a quote which is 11 year’s old just to prove a point.

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We don’t know what PFS is. Once it’s really researched a therapy that’s functionally a cure might only be 5 or less years away. Once earnest research gets started. Not just a guy in Italy testing one little idea on a shoestring budget and one study from one guy in the US that never comes out. If it’s actually the epigenetic stuff then we might already have a cure – the Sinclair and Ozeph epigenetic reset protocols.

IMHO this meme that there will never be a cure anyway is a rationalization for not doing anything except sitting on forums and googling “libido boosters”.