Pretty detailed paper here from Penn State. I posted some of this quite a while back on Acne.org
Yes this list is absolutely ridiculous. That’s the point.
In comparing the gene array data from the pre-treatment biopsies to the 8-week
treatment biopsies, 197 genes were significantly up-regulated and 587 genes were significantly
down regulated as determined by using a false discovery rate (FDR) of 0.05, that corresponds
to a 5% chance of false positive genes among those genes considered significantly changed.
Select genes that were up-regulated by approximately 2-fold or greater and genes that were
down-regulated greater than 4-fold are listed in Table 6. For a complete listing of all significantly
changed genes at 8-weeks, see A.1. Many of the down-regulated genes at 8-weeks are
involved in the metabolism of steroids, cholesterol and fatty acids, which is consistent with the
known decreases in sebaceous gland lipid production induced by 13-cis RA
All significantly changed genes after 8 weeks isotretinoin therapy
You’ll find this if you do a search,