I believe tribulus has cured me!

Therapeutic Efforts Supplements & Lifestyle
#289

Hello awor

What do you think about Apr1989’s post? do you think its epigenetic?
what I am trying to understand is when I was taking SP I got very high libido all I was thinking about was women. after stopping and starting again I had same “positive symptoms, high libido” at the end libido gets low but “higher than normal” and you don’t think about women “less interested” because of less DHT.
My understanding is this: Fin and SP block testosterone to DHT conversion this increases testosterone super high. DHT gives you high libido but when it gets dropped down you are not interested in sex.
about super high testosterone that you have is lowered by human body by sending less signal to hypothalamus and the pituitary-gland to make less LH and FSH right?
Or high testosterone caused the androgen receptor insensitivity?

Is this theory wrong is this guy wrong?
can you give me directions?

Thank you

#290

I outlined my thoughts on this here and here as well as in other posts.

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#291

In the same breath you have a patient here who says a geneticist at the same Baylor university told him it was an “impossibility” that finastride could cause epigenetic changes or alterations…

#292

Did this geneticist have anything to do with the PFS study? Is the source of this information legit/honest?

#293

That’s interesting :slight_smile: Who said that?

#294
#295

@MOONCHILD, can you elaborate about your visit to Baylor?

Are you certain that the geneticist said this in regards to “epigenetic” changes and not just “genetic” changes?

Did he have any awareness of the PFS study that took place there, or any background information about the condition?

This sounds like the response of someone who simply checked to see if finasteride has an effect on epigenetic mechanisms more directly than through androgen levels, saw that it didn’t, then gave his assessment.

#296

As I said before, I made an appointment a geneticist at Baylor College University in Houston note:(He is not related to the Mohi Khera study) .
He told me that " yes" he heard about PFS, but he don’t believe that 1mg of finasteride would cause any epigenetic change, more less a genetic level, he told me that it is impossible, and also it doesn’t inhibit DHT completely, that was his statement.
I ask him in case that were an epigenetic modification, if would be permanent, he said that epigenetic modification are not permanents, that can be lasting but not permanents.
I mentioned about Khera study and he said that he dosen’t know how Khera will turn on back the silents genes.
I ask him abut CRISPR and he laugh, he said that CRISPR is in the infancy and I will take years before it going to be implemented.
He didn’t charge me for the visit.

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Altered methylation pattern of the SRD5A2 gene in cerebrospinal fluid of post-finasteride patients: a pilot study
#297

Anyone that thinks CRISPR is the answer needs to have their head checked

1 Like
#298

Really no, crispr could do more than what you think, trial started already in US, the problem is who are going to push CRISPR to fix PFS?
But the truth is that I don’t think that CRISPR is the inmediate answer to PFS at this point, maybe brain stem cell is.
Billions the BRAIN stem cell than can replace the old damaged cell by finasteride and start producing the new and substantial amount of neurosteroids could be a solution.

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#299

We don’t know about the background of PFS.
Before talking about CRISPR, we have to wait for baylor or other study.
My concern is, PFS is very specific disease and people don’t know about this.
It means speed of the research is very very slow.
But thanks to axolotl and awor, we can get a hope getting out of PFS. at least root cause of PFS…
Hope to see Baylor study results in this year…!!
It can be a game changer or useless.
But many years of study, i hope it will be a good opportunity to get a chance!

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#300

I been using tribulus for last 5 week and is working incredible well, I been up and down in dosages, not exactly as Apr1989 recommended and work.
My libido sky rocked like never before, I will say like pre-finasteride, my erection problems was solved already before Tribulus, If I still the way that I has been for the last 2 days I am totally recovered.

I finished the whole Tribulus bottle

Note: For the last week I used Tribulus + L-Dopa. then it was when I noted the big difference.

I will post my protocol later.

9 Likes
#301

You’re a gent MOON, thanks!

Well my own experiments are still kinda experimental! I’m now able to tolerate the tribulus, but I don’t know if I’m just tolerating it or getting benefits from it or anything. I think if you’re like me and it makes you feel worse initially you’re in for a slightly shitter time in trying to get it to work, if you want to force that sort of thing. It could have been the sulforaphane, the crash following some licorice root, overmasturbation for a week (I could do that after the sulforaphane,) the tomato juice protocol in which I worked up to the MediHerb from the (perceived as weaker) VemoHerb stuff, supporting GABA and other animals with Amitriptyline/5aDHP for a week or, of course, could have ‘just happened’.

I used to just feel worse, but now mentally feel a bit better. Sexually still in the shitter and no change, but running the tomato juice protocol instead currently not Apr’s cycles. I may get back to those during the summer and see now tribulus isn’t slaying me. Last experiment I wanted to try with it is cycles vs building up and then abruptly stopping, seeing if the magic is in the ‘snap back’ afterwards for guys like me. Off the back of MOON’s experiments too might ALSO try L-dopa too.

#302

Very interesting, I also used l-dopa (mucana puriens) and it pretty much cured 80% my sexual symptoms. I quess its rather because of the l-dopa you got this improvement and less because of the tribulus. Did you even improve with just tribulus?

#303

I am feeling 100% recovered from libido, and ED, I have really strong erections, erotic dreams are back and morning and nocturnal reactions are also back, penis sensitivity, pleasure of the orgasm are supper, all the sexual side are recovered period.
The libido was the most difficult to achieve, Tribulus + L-Dopa I think that was the key

I started with low dosage of tribulus following Apr1989 advise, I used low dosage like 1 or 2 pill at day for 2 or 3 weeks, then increase like 3 to 4 pills at day for one more week, then I increase the dosage very quickly to 9 pills at day as follow:

Tribulus 3 pills morning
Tribulus 3 pills afternoon
Tribulus 3 pills night

Then the next week I add L-Dopa

( Tribulus 3 pills + 2 L-Dopa pills) morning

3 Tribulus pills afternoon

( Tribulus 3 pills + 2 L-Dopa pills) night

I remember that I have a rest in one or two days in between and I jump back to 9 Tirbulus pill + the L-Dopa.

I will continue cycling just in case, lest see how it goes from now on, I hope it going to last.

I remember that I also I have a recent crash with creatined that I started to add it following my first cycle of Tribulus and before I add the L-Dopa.
I recovered very quickly and started to feel better than before the crash.

7 Likes
Androgen receptor overexpression and sensitivity to hormones reversed by epigenetic therapy that restores Pur-α to a transcriptional repressor complex of AR deregulated in HRPC
#304

@MOONCHILD What brand of Tribulus are you taking. This seems to be very important, is it the same MediHerb version that @Apr1989 is using?

Thanks!

#305

Is there any particular L-Dopa you guys are having success with? I’m going to have to try it.

#306

Wow , congrats, hope changes are permanent for you. I am trying the same thing now. How long it took to see the improvements ?

#307

I was already fine with strong erections before Tribulos, I think that since my fasting practices I noted that my erections started to get stronger, and recently I didn’t have any issue with ED, the only think that was missing was the libido, it was sometimes when I was feeling low libido, other times I was feeling like normal libido (but not often) or low normal, but in reality I was more like low libido most of the time, there were occasions that I feel like high but vanished soon after.
I think that time also could be a factor in my recovery, but I really notice that Tribulos Cycle and Tribulos+L-Dopa Cycle sky rock my libido.
Also I notice a big improvement since my creatine crash. but I have to admit that before I try creatine I was already prime with Tribulus.
I remember that the day before that I started to coming out of the creatine crash, I was feeling like my head want to explode (headache) and the next day during the morning, in the afternoon I started to improve and by 11:00 pm my headache was gone, then I started to feeling better and better.
I also remember that after I came up from the creatine crash, I started to use L-Dopa + Tribulus and I feel like needless and pin sensation inside my brain very weird feeling.

Note: It may help I added to my die cow milk and cheese. (Dairy products)
No too much just drinking one or 2 glass of milk a day, some days I eat a piece of cheese…normal diet

I wanted to upload the picture of the Tribulus and L-Dopa that I used, but said that the file is too large.

I bough it in Vitamine Shope store here in USA.

Macuna pruriens Seed Extract ----------400 mg
( 15% L-Dopa, 60mg )

Tribulus Terrestris Extract 625 mg
20% saponins (125 mg)

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#308

Immeasurable thanks for your post!