Suppressed 3a-hydroxysteroid may be the cause?


#83

My body odor did go away for over a year after developing this condition, but oddly enough returned sometime during 2018. I can’t pinpoint exactly when it came back or what brought it back, but I once again noticed that I needed to use deodorant and wear a different shirt every day again. It was a nice return to semi-normalcy, but it didn’t really come with any resolution in other symptoms.

On a related note, my BO has actually decreased a little bit since starting broccoli sprouts. I suppose that’s good evidence of it suppressing DHT.


#84

Did you start eating Broccoli sprouts on purpose? and will you stop ?


#85

What’s BO ?

I’m seeing changes with Sulforaphane but not what I expected. Sleep is not better.

However, I have more motivation, I’m more focused and brain fog is gone. I’m also in a better mood, having more emotions.


#86

Body Odor


#87

i think GABA is more responsible for sleep isnt it?

i know allo should help with that as well but maybe you need direct allo to correct levels like what sage is doing


#88

#89

Keep us posted about sulforaphane!


#90

Ok. So body odors do have something to do with pfs symptoms. My body odors are gone again. So yes, it may have to do with taking both Pine Pollen and Horny Goat Weed at the same time. That’s a finding by itself (for those interested in having to put deodorant. Lol)

I think Sulforaphane is not going to give spontaneous response like taking 5-HTP or L-Dopa. (or a testocaps, they always gave me a rush). I’m at 200 mg a day now. If after sometime I still don’t see effects, I’ll try with DMSO. Truth is, I do have some feelings that seem to come from the past. But it’s not obvious at this point.

I’ll keep you posted.


#91

Confirmed for body odors. If I take both Pine Pollen and Horny Goat Weed things return to normal.

About Sulforaphane:

I had a bad night of sleep last night. 4/10 . The weird thing is I was tired at bed time and went to sleep fast but I just kept waking up and falling in a light sleep, dreaming all the time. The dreaming zombie state as I call it. I usually feel not rested after a night like that.

I made five changes in my regimen:

I’m taking Creatine. It could be it but it’s said to be to be non-stimulant and can be taken even before sleep. (for non-pfs people anyway). It boosts testosterone and androgen, but only if you exercise which I haven’t done that much. I’m in the load up period and still suppose to load up for 3 days but I’ll just take the maintenance dose for now until I can fix my sleep.

I’m taking 4.5 mcg of Boron if adding my multivitamin. I doubt this makes a difference. The upper limit is 20 mcg. 10 mcg is used to boost testosterone.

I’m taking Horny Goat Weed once in the morning. Could be that, but it’s supposed to affect testosterone and sex drive, not sleep. Plus I stopped One day and sleep was bad anyway.

Sulforaphane. Yesterday I took around 300 mg. It did make me feel calm yet confident and motivated during the day, and I was sleepy before bed. But I slept bad while just a week ago, before any changes in my regimen, I was saying sleep was getting better. ( 8.5 or 9/10) Today I will reduce to less than 100mg and see what happens.

Sleep patterns: The 2 months school vacation just started in Thailand last week. My sleep patterns are all messed up. I go to sleep at the same time but wake up at 8 instead of 6:30. So instead of 8 hours, I get 9 and half and that, by itself, has always caused bad nights on the next night.

So I’ll fix my night pattern, that’s the best educated guess I can take as oversleeping has always resulted in bad sleep the next night. I’ll cut down Sulforaphane to less than 100mg until I get better sleep. If after fixing my sleep patterns I still can’t sleep good, I’ll have to cut Sulforaphane.

Following my regular rules,Sulforaphane didn’t significantly make me feel better while I did have bad side effects. I still cannot attribute those to Sulforaphane but after fixing my sleep pattern, I’ll know what’s the cause of this bad sleep.


#92

Hi. Do you have any study regarding this fact? Thank you


#93

I looked again and I have been wrong. My sources were from a hair loss forum and it was incomplete.

5-ar produces DHT and 3a-HSD eliminates DHT in the muscles. Both are working together and are essential to produce ALLO and other important neurosteroids.

However, as far as I’m concerned in raising 3a-HSD levels (with Sulforaphane), I will also want to raise 5-ar levels to make sure I have normal DHT.


#94

And to answer to myself on this post, I did fix the sleep patterns and slept better. Sleep is no longer an issue as long as I don’t sleep more than 8 hours.
I decreased Sulforaphane to 50 mg a day which seems to be adequate and I found that it was either improving the effect of Tyrosine, or using it at a much faster pace. As a result, after taking Sulforaphane I stopped having brain fog and became more focused. I also have an inner calm I haven’t felt for a very long time (years) but I ended up depleting my Dopamine and Serotonin. (felt demotivated, unhappy, depressed, and unsure of myself)
So I continued to take 5-HTP 100 mg, L-Dopa 350 mg, L-Tyrosine 375 mg, all three two times a day and I also take half a dose of St-John’s worth (300 mg, it’s a plant extract) which is a unique non selective, all neurotransmitter re-uptake inhibitor to prevent my Tyrosine, Serotonin and Dopamine from being depleted.
5-HTP and St-John’s Worth are dangerous together so I monitoring how I feel carefully, taking only small doses of that herb and I’m ready to stop it the moment I feel a dopamine or a serotonin rush (after months of testing those, I know how too little or too much of those feels like). Stopping St-John’s Worth would let my body flush the extra neurotransmitters. At the same time, to make sure, I would also stop the intake of the neurotransmitter that seems over-abundant.
And considering Tyrosine seems to have a greater effect, I’m taking a small dose of Phenylalanine (350mg per day) to prevent depleting that one as well. Tyrosine and Phenylalanine are the precursors of the neurosteroids responsible for regulating the nucleus acumbens, where all the Dopamine receptors are located. (I could name those neurosteroids, they have long, funny chemical names that look like they come from a Star Trek episode)

For a second day in a row, I felt more normal than I did in years. Even more normal than when I was taking fin (in the end, it was making me very irritable).
I’m not suggesting any of you try what I’m doing. As a matter of fact, it can be dangerous. I’m just documenting what I’m doing and the effects it has on me.

I’m looking forward to a good night of sleep and a fully motivated, productive day tomorrow.

I’ll keep you posted (more on Amino Acid For neurological symptoms)