Could you bring this article excerpt about androgen gene transcription into context with mifepristone?
Very curious about your ideas as to what might be going on.
The androgen receptor (AR) mediates the physiologic effects of androgens (T, DHT) by binding to genomic androgen response elements (AREs), which influence transcription of AR target genes (70). In the process of transcription, the target gene DNA sequence is copied into an intermediary molecule called RNA. Transcription is controlled by other DNA sequences called transcription factors, which show a cell where genes are located, and control how often they are copied (71).
The RNA copy made from a gene is then fed through a structure called a ribosome, which translates the sequence of nucleotides in the RNA into protein (71). In some cases the protein must undergo further transformation in the form of posttranslational modification in order to become a functional gene product (typically a protein). The functional gene product (gene expression) is ultimately what exerts androgenic response in the body (70). If this gene product is not expressed at normal levels and correct form, androgen dependent functions will fail.