If the anti-inflammatory benefits were responsible for the remission, then aspirin would do the job as well, which it doesn’t.
RedStaR
I exhort you to do an investigation first before assume any comment. you can be tearing down a possible cure without knowing.
To begin with aspirin is a non steroidal anti-inflammatory, the mechanism of action is totally different, for example aspirin do not at on dnmt1 directly, in other words do not act in the same pathway as Methylprednisolone. also the dose of Methylprednisolone seem that the dosage play an very important role, in this case 1000mg is arelly high dose.
Note: There are some risk implication
The supranational can be affected if and also diabetes risk if:
“The medication is used for too long.and if Methylprednisolone the is withdraw a cold turkey.”
of course all this risk can be avoided if the medication is given under a professional supervision
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Then let’s make a distinction between anti-inflammation and GCR agonism.
If you read the whole article:
http://cancerres.aacrjournals.org/content/75/15_Supplement/1052.short
it is more than clear why Anonymous is recovered.
Result that Methylprednisolone act in the same pathway ( TNFR1/NF-κB/IL-6/DNMT1 ) that silenced SRD5A2 with lipopolysaccharide (LPS).
Treatment with both LPS and TNF-alpha inhibitor reversed this pathway and reactivated SRD5A2.
Note: Dihydrotestosterone Stimulates Cerebrovascular Inflammation through NFκB, Modulating Contractile Function
Imagine a brain working without DHT for a period of time, right ? inflamation really low because not DHT, what do you think that going to happen when you withdraw Finasteride ?
Well I will tell you: for sure an immune response are going to be in place, it explain brain fog, sleepiness and other issues without counting the side effect of having SRD5A2 silenced and possible others genes due that DNMT1 and global methylation.
What ever is Methylprednisolone seem reverse the effect caused by Finasteride and is proved by accident with Anonymous.
The only problem here is to find a doctor willing to prescribe and apply the medication to any of us.
I asked to my doctor to apply it and she didn’t want to cooperate, I will continue looking for any other doctor willing to help with it.
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It’s almost impossible to find a doctor who will inject that. I mean its not a smart move to tell them you have PAS/PFS . 99% of the doctors dont have enough competence or qualification to be aware of these syndromes. The only thing i can think of to buy pills instead of liquid form.
Pills will not work of you don’t use the right dosage + can put you in real danger, if you try to equal the dosage with pill you are going to need to digest large amounts can be be dangerous.
If not possible to be delivery trough vein, I will not do it.
What do methyl steroids and trib have to do with each other? Are you saying we should try trib or methyl steroids? My issues are mainly visual and I’m starting to believe it’s inflammation of the optic nerve. Had my eyes checked and my nerve/neurons in my eye are much less dense then they should be. Is there a risk to methyl steroids? I’m considering mayo as well.
This may be a stupid question, but a simple google search did not yield much. Is there any testing to determine brain inflammation?
Methylprednisolone is a DNA Methyltransferases Inhibitors
Now look what this article said : The use of specific inhibitors of DNMT might reactivate those genes and stop or even reverse the aberrant cell processes.
It mean that DNMT inhibitor can reactivate silence genes.
@axolotl, @awor, what do you think about this? Methyl steroids seem to be used from some neurological disorders like MS - you think this holds weight?
Please try to stay on topic.
This discussion of methylprednisone and autoimmunity has been moved from a topic focused on tribulus as a treatment method.
Even if you gradually build up a dose ? Accumulation doesn’t work in this occasion ?
Do you guys think the oral form would work? I bet it would be easier to get that
Not sure you can take dosages that high orally… I dunno. The small amount of googling I did on it sounded like it was a worse idea
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Let me explain you something, inflammation is always there, basically everything that we eat cause inflammation at cellular level.
This is my theory.
Finasteride have anti-inflammatory proprieties.
https://www.ncbi.nlm.nih.gov/pubmed/19007044
DHT is a pro-inflammatory.
DNMT1
DNA methylation -mediated gene silencing, DNMT1 also binds to several transcriptional inhibitors
Methylation at previously unmethylated sites is catalyzed by a DNA (cytosine-5)-methyltransferase, such as DNMT3a/b, and is commonly maintained by DNMT1, referred to as maintenance methyltransferase. Together, these enzymes guarantee that a substantial part of the genome is often methylated, leaving only regulatory elements like promoters and enhancers, as well as CpG-rich islands, in an unmethylated state (Lindroth and Park 2013). The hypermethylation state of DNA at the promoter is predominantly associated with gene silencing. There is also evidence pointing to multiple epigenetic modifications, including DNA methylation and various histone modifications, that can work synergistically or antagonistically (Lindroth and Park 2013).
My Theory
Our brain was accustom to the normal inflammation ( pre-finasteride), on finasteride inflamation goes very low and or brain get accustom to it very quickly, when we withdraw Finasteride inflamation rise + DHT rise and with it rise even more inflamation, our inmune system react through DNMT1 increasing inflamation casuing Methyliation of the CpG islands as result silencing SRD5A2 and maybe others genes involved in the same pathway. causing all the symptoms that we are feeling.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3521964/
Note: The methylation of CpG islands results in stable silencing of gene.
The more I read and analyze it the more pieces come to fit.
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this guy already confirmed that methyl steroids did NOT treat his impotence. Also, I have had hallmark pfs symptoms for nearly two years and have went on corticosteroids twice and have had zero noticeable effect. just fyi
How do you explain the people like myself who took 1 or 2 pills and had an almost instant and extreme reaction?
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Methylprednisolone for sure don’t cure impotency,
What you do not still understand the issue here. The issue here is epigenetic and it is what Baylor still currently doing a research and Milano university is going to do another epigenetic research.
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this guy already confirmed that methyl steroids did NOT treat his impotence. Also, I have had hallmark pfs symptoms for nearly two years and have went on corticosteroids twice and have had zero noticeable effect. just fyi
The problem here is not to going on corticosteroids, the proble here is #1 dosage of corticosteroids and what type of corticosteroids, #2 you need to make sure that the used corticosteroids also have to cross the Blod Brain Barrier (BBB).
You guys come to a conclusion to quick and that’s why you never going to anywhere just acting like that.
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