Amino Acid For neurological symptoms

Therapeutic Efforts
#243

Day 9 of Sulforaphane and Day 110 of amino acids experiment.

Sleep was not as good as yesterday. I give it 7.5/10 which is fine. I’ll have a good day. I think it’s because I ate late and still had food in my stomach when I took the sleeping pills. I should really finish eating before 6pm.

Also, the night before was after a very bad night of sleep so naturally I was more tired and slept better. Yesterday’s night was after a good, restful night so it would be more ordinary.

And lastly, I forgot to take Inusitol (vitamin 8) 4 gr before going to sleep. This one usually helps a lot. If I wake up and can’t fall asleep I take 2 gr of Inusitol and will fall right back to sleep. So considering I had and average good night without it is Ok for me.

This morning, I feel the deep calm inside again, and I’m motivated focused and full of energy; ready to take on a full day of work.

I will take a low dose of Phenylalanine (to balance Tyrosine) as well as half a dose of St-John’s Worth as it seems to maintain the good effects of the aminos and prevent depletion of Serotonin and Dopamine. It looks to me, and I can be wrong, that by introducing Sulforaphane I’m using more Tyrosine and lowering Dopamine and Serotonin. This would account for brain fog disappearing as that’s one of the noticeable effect of Tyrosine and using more would mean less brain fog. (although it’s just a theory of mine)
I’m very careful about St-John’s Worth. If I feel bad in any ways or for any reasons, I’ll stop that one first.

#244

Day 10 of Sulforaphane and day 111 of Amino experiment.

Sleep has improved to 8/10. I could also say 8.5 or 9, but I leave room for further progress. I don’t want to end up saying I had a 11/10 night, which I consider inconsistent. (it means the scale didn’t end at 10 and I would have been misleading you all the time). But that not important.

What is important, is that I went to sleep around 10:45 pm, slept in one shot until 6:30am (that’s almost 8 hours) then because I felt groggy from the pills I stayed in bed until 7am and finally took my wake up pills.

I call them wake up pills because I take them before anything, at the moment I sit down on my bed, and they contain Calcium Lactate and Calcium Pyruvate, both of which enhances the activities of the Orexin complex (that’s the neuropeptide responsible for wakefulness) while at the same time giving me calcium which is better taken in the morning as it promotes muscle contraction (when magnesium promotes muscle decontraction. If you have cramps, you have too much calcium compared to magnesium. Take Magnesium chloride in water, 1/4 to 1/2 tsp of it, around 4 pm-6 pm. Your body will have time to flush the excess before sleep, cramps will disappear and sleep will improve. Taste like shit, this is why I made an electrolyte recipe that gives 100% the magnesium you need everyday while tasting good. See my regimen.)
I also take 5-HTP 100 mg, L-Dopa 350 mg and Tyrosine 375 mg, as well as all the vitamin B complex including biotin (well not all. When companies say vitamin B complex, they usually exclude B5 and B8, which are not common and sometime even B6). Anyway. All of that are stimulant so 10 minutes after taking them the grogginess goes away.

Sulforaphane is having the effects I was expecting. As expected, it threw me off balance and I had to adjust the other supplements and aminos I’m taking but now that is done and sleep is improving, The deep calm inside is settling down and I hope it will stay.

I will most likely need to balance things out again as I progress, Sulforaphane seems to act slowly and have an increasing effect. Not the kind of supplement where you get your effect in 20 minutes and it’s gone after 8 hours. I expect at some point I will have to decrease Clonazepam (at last). If I can get rid of it, considering it acts on GABA (A) receptors, I will be able to use a multitude of herbs that have GABA effects without being addictive and damaging to the liver. Right now I can’t, they interfere with Clonazepam and have abject effects.

I’ll keep you posted.

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#245

This is really encouraging news. I look forward to reading about your further progress. I feel like the day you post that you have completely weaned off Clonazepam, I will have to book a flight to Thailand to buy you a celebratory drink (even though I know you dont drink). Cheers!

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#246

Thank you my friend. You’e welcome to Thailand anytime !

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#247

Day11 of Sulforaphane and day 112 of Amino experiment.

Sleep degraded a little.7.5/10. I took the sleeping pill way too late and first half was a bit agitated. I have to take the pills at 8pm and go to sleep at 10:30. Eating some cheese before bedtime seems a good idea too. Worked in the past.

It was was really hard to get out of bed this morning, thanks to taking the pills late. Cant wait to NOT have to take those pills. Ill try decreasing Clonazepam a bit this evening, and increasing a bit Sulforaphane this morning, and see what it does.

Somehow, I predict a more energetic day and a worst night but if I change those 2 stuffs doses just a little it shouldnt be dramatic. I want to taper off Clonazepam and change it with some other anxiolytic plant that would be more natural. I think Ill do the transition with lavender oil (silexan). The trick will be to take only 1/4 of a gel cap filled with oil. Ill have to use a syringe needle like a straw and only sip out half of the content… Although it will mess up my androgen, it would just be for a short time so I can get off Clonazepam. I know for a fact if I take those two together, it doubles down and I get hammered (instead of getting an adverse reaction and a sleep less night like I get with Clonazepam and Passion Flower or Valerian). So a little of both should do the trick.

Let`s see.

#248

Day 12 of Sulforaphane and Day 113 of Amino experiment.

Slept 7/10 which is not bad at all considering I went from 3.5 mg Clonazepam to 2.5 mg, but added 80 mg of Silexan.(lavender oil. If I grow boops, I’ll identify as a woman and problem solved)

I intend to taper off Clonazepam and start taking GABAergic herbs to deal with GABA and sleep. I’ve been slowed down on my experiment on GABA for too long and it seems at the center of the problem.

GABA receptors are regulated by Allopregnanolone which is produced from Progesterone via 5ar and 3a-HSD. With pfs sufferers, 5ar is low and 3a-HSD is pretty much inexistent. I’m doing my best to boost both. I added a branch of fresh broccoli to my Sulforaphane intake, so I can get the proper enzyme to transform it.

Also I noticed Sulforaphane really helps clear brain fog. But it depletes Dopamine. So I added 500 mg of Tyrosine (Dopamine precursor) when I take Sulforaphane. I’m at a total of 1250 mg of Tyrosine throughout the day, + food = about 6000 mg (steak has a lot of Tyrosine)

Apocrine glands (BO) still seems to be working on Tribulus Terrestris, if I add two drops of polllen DMSO.
Horny Goat Weed was more efficient.

#249

Day 13 of Sulforaphane and Day 114 of Amino experiment.

Slept 4.5/10. I took only 2.0 mg of Clonazepam, and I guess my body had time to flush out more of what was accumulated so I really got the result of what it looks like if I take a little more than half my usual dose: 3 hours of sleep, then I wake up completely awake. I kept 2 gr of Inusitol in a glass next to the bed (just add water and it’s ready, like instant noodles) so I took that and spent the rest of the night half asleep (but barely) and half awake, with lots of unpleasant dream mixing with reality.

Whatever Sulforaphane is doing, it’s not boosting Allopregnanolone. I still have all the symptoms of unregulated GABA complex. So far, what I get from Sulforaphane is greater focus and no brain fog. I also need to take an extra 500 mg of Tyrosine and 375 mg of Phenylalanine to counter-balance the shift in neurotransmitters Sulforaphane is creating. It does work though.

So I’ll resume taking Clonazepam. I bought some Phenibut and I will test it along with the anxiolytic herbs and aminos (GABA and Taurine) that I have, one by one, and see which one I can tolerate.

I haven’t given up yet. If GABA regulation and production, and Allopregnanolone production can be restored, I’m sure all the rest will improve.

I’ll post all of that.

Update: I’m actually feeling really mellow. I’m tired, but I’ve been stressed and tired many times in the past. This time Ièm just tired and mellow. I’ll take another 1000 mg of Taurine around 4:30pm. Being mellow and relaxed is what it’s supposed to do, so maybe I am getting benefits from Taurine.

On another note, I took Sulforaphane with 500 mg of Broccoli extracts powder and a branch of raw broccoli today. This is in order to get the enzymes needed to metabolize Sulforaphane. Maybe I’ll get better results at boosting Allopregnanolone (by boosting 3a-HSD)

#250
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#251

2 things I wanted to add to help you with your strategy. (you may already know these).

  1. Klonopin builds up in your body fat over time. So the taper process has to be really long. I think some MD told me the half life for most of Klonopin is like 3-5 days. I think your adjustments to your done will have to be adjusted more slowly to see actual results on dosing. I’m not a Dr. but I think what I’m telling you is basically correct.

  2. I use Phenibut and have done extensive research on it to make sure I use it safely. I started at 250mg to try it and it worked amazingly well. You have to be EXTREMELY careful with how often you use the stuff. I have read that if you use it twice in 1 week that you need to take at least a week off before using it again. The highest dose I have used is 500mg. I try to space my uses 5-7 days apart. I cant say it improved any symptoms but you certainly feel very well rested after taking it. Thats a guranteed 10/10 sleep for you. Good luck and be safe.

#252

Thanks for the cues Shellnyce.

I’ll keep that in mind next time I try to stop but I’m not trying to stop Clonazepam anymore. Just try to get back to what’s normal to me and try different anxiolytic herbs and see if some can be matched with Clonazepam without adverse effects. Then maybe I will reduce slowly. I don’t have much body fat where Clonazepam (or Estrogen for that matter) can hide, Anywhere I pinch my skin, it’s 1/4 inch thick.

I’ve read about Phenibut. I know it’s not and every day thing, but a 10/10 once a week is fine. it’s like a holiday! I’ll read more about it before taking it.

I wonder why the supplement says take 1-2 capsules everyday: Maybe it’s a different variation of Phenibut. Can you tell ?

#253

Day 115 of Amino acid experiment. I will stop counting Sulforaphane unless I get distinct effect from it. Until then, I will use it along with broccoli extract and raw broccoli and see what happens.

Sleep was 6/10 yesterday. Getting better and enough for the day.

I had anxiety yesterday afternoon. I tried eating oatmeal when taking amino acids. Apparently, the less protein you eat when taking aminos, the more of the aminos passes through the brain barrier. But I get anxiety when I eat too much carbs. So I’ll take the aminos on an empty stomach and it will do the same.

Aside from that, I’ll just try Taurine 1000 mg once before lunch and that should do it (to keep me mellow)

#254

I was pretty sure you were well informed. I felt like when I wanted info on trialing phenibut, there was very little useful info. What worked for me was 250 grams an hour before bed. Start low and work your way up. Cheers. Keep up the great thread!

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#255

Day 116 of Amino Acid experiment. Sleep at 6/10 again. I sleep a few hours, then I’m fully awake and drowse in and off a very light sleep with very awake moments and surface dreams for the rest of the night.

Yesterday I tried Taurine and GABA in the afternoon and all I got was anxiety late afternoon and evening. So today, It’s back to regular regimen with no particular addition except Sulforaphane and extra Tyrosine to counter balance the extra use of it. Serotonin being lower, as well as Dopamine shows me Tyrosine is being used up. So I decided to take 5-HTP and L-Dopa on an empty stomach without food proteins competing with the amino supplements to see which one going to cross the brain barrier. It works.

Because I have high hopes for Sulforaphane and because I heard it takes some time to have effects, I’m going to give it a 30 days trial. After that, If I don’t see any improvement in ALLO, I will most likely taper off. I had anice balance before I tried Sulforaphane and was having nights between 7.5 to 9/10. I can live with that.

My remaining options are to wait for a proper drug that increase either 3a-HSD or GABA. Currently, GABA remains an elusive neurotransmitter with regards to increasing its presence. It’s not as straight forward as Serotonin, Dopamin, Nor-ephedrine, Acetyl-Choline or others. Maybe it’s because it’s much at the center of it all. GABA has an effect on our will to live and reproduce. That’s survival and reproduction, our two only biological and instinctive objectives. Gaba disability does more than anxiety and insomnia.

I’m interested in trying Ashwagandha in the day time or night time. It’s a nootropic, adaptogen herb that mimics GABA, increase Dopamine, decrease Cortisol and support thyroid, adrenal and sexual glands. It’s got many benefits and an adaptogen for neurotransmitters sounds just like the right thing.

Let’s see.

#256

Day 117 of Amino Acid experiment. Same again. Sleep at 6/10. I sleep a few hours, then I’m fully awake and drowse in and off a very light sleep for the rest of the night. I forgot to take Inusitol, the night beofre took double dose (10 gr.). Same sleep pattern… I’ll continue with 4 gr Inusitol in milk and honey, taken with cheese before sleep. This has worked well in the past. I’ll also slightly increase the antihistamine from 6 mg to 8 mg. The sedative dose is 80 mg to 120 mg so I’m still far from it.

I’m taking the same basic regimen, as described in Ozeph Regimen and Supplement, although yesterday I ate in restaurants all day and had normal food. It didn’t seam to change anything. That’s a plus if you ask me.

But since I tried to cut off the benzodiazepine, I can’t seem to get normal sleep. Sulforaphane has changed the way I take aminos too. i need a lot more Tyrosine. Maybe that’s why my good sleep hasn’t returned.

I’ll try 4 gr Inusitol if I wake up again (or most likely when) tonight.

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#257

Day 118 of amino acid experiment. Sleep 9/10 I think I remember slightly waking up somewhere in the middle but went back to sleep straight away. I barely woke up a few times when I turned around and back to sleep again. I don’t write 10/10 because. That’s the ideal sleep, when you go to sleep fast, never wake up, and then fully wake up, well rested 8 hours later. But I’m not even aiming for that 10/10.
9/10 is good enough and I feel blessed I can have it, even if not all the time.

So here’s what I did: I had Inusitol 7 gr with 1/2 cup of warm milk and honey and 3 pieces of cheese before bed.
Honey and cheese before sleeps seems to be of major help to not wake up full awake after 3 hours. I recommend it to anyone having this sleep pattern. Apparently, a cracker with peanut butter and Jam does the trick also but for a French guy like me, cheese comes to mind first (plus it’s high in Tryptophan) and peanut butter and jam is a weird mix for me (I tried it. I guess it’s an acquired taste). But whatever suits you: you need a small portion of protein, fat and carbs to provide energy for the night, so you don’t have a cortisol / Adrenalin / Nor-Adrenaline spike during the night when low on energy. That’s why we wake up after 3 hours. That and pfs of course.

Also for those interested, lack of Choline is linked to short term memory not transferring to long term memory. Choline Bi-Tartrate will help with that, along with eliminating excess estrogen, excess fat from the liver and regulating the vagus nerve. I think it’s an important supplement.

I didn’t take Taurine, GABA, Phenylalanine during the day. I’m ruling those out of my regimen, they give no results or bad results.
I increased Anti-Histamine (hydroxyzine) to 10 mg and Clonazepam to 4 mg (I’ll try to lower to 3.5 mg, which was the dose I took before trying to taper off)

I changed the timing of the second dose of 5-HTP, L-Dopa and Tyrosine to 30 minutes before lunch and increased Tyrosine. The recommended dose is 1000 mg for 100 mg of 5-HTP. I’m still not there but will increase to 1000 mg next week.

For the moment, I’m back to normal. Normal days. Normal nights. I’ll keep it like that for a while before trying anything funny. Next trial: Schisandra (which is not supposed to be active on GABA but boosts Dopamine and sex drive), Bacopa and Ashwagandha, (both of which are adaptogen that balances neurotransmitters where needed) and eventually Kava Kava and Passion flowers which acts directly on GABA but interact with Clonazepam (So I’ll have to stop Clonazepam before trying them, easier said than done)

All changes are updated in Ozeph Regimen and Supplement.

I’m happy I can temporarily crash and get back on my feet on a relatively short period of time.

Update: I don’t know if it’s Sulforaphane or taking the 3 brain aminos before lunch, but I’m definitely relaxed while having energy and focus.

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#258

Day 119 Slept not as good. 6.5/10. This is due to stress at work which wasn’t resolved when I went to sleep. I already had anxiety when I took the sleeping pills.

Not much to say. There’ll be some ups and downs…

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#259

Day120 Sleep getting worst. 5.5/10. This time, it’s because instead of taking a light snack before sleep, I ate until full and had lots of carbs. I’ll stick to 2 pieces of cheese and 1/2 tsp of honey.

I also started taking Schisandra and Bacopa in the morning. Bacopa first time this morning, and Schisandra first time yesterday morning. Those are not supposed to affect GABA and take a few weeks to kick in but both have anxyolitic effects through the CNS. Maybe Schisandra is the cause of bad sleep, but it’s actually supposed to help insomnia. So I’ll just test it.

I’ll try cheese first and see if it helps. (I’ll also eat more at dinner so I’m not so hungry before sleep)

If the herbs makes me feel worst, I’ll stop.

Update: Weird thing. Unless I get a really bad night of sleep, it doesn’t affect me at all during the day. I’m just as concentrated, motivated, good spirited etc… as usual. No symptoms at all.

#260

Day 121 Sleep was much better.8.5/10.

I did everything I did before, the only changes are I took a larger, fatter dinner and I had only 1 piece of cheese along with a little milk before bed. So carbs before bed, carbs in the afternoon, carbs at dinner, all have failed.

The only carbs that didn’t fail so far was carbs at breakfast and lots of activities to burn after.

So I’m gonna stick to least carbs possible, down to zero, as much as I can.

#261

Day 122 I took a five day holiday on an island with my wife and 3 sons. It’s nice to swim in the sea, very relaxing and all, but I’m off my ketogenic diet and I’m eating shit like liquid vegetable oil and tons of carbs.

As a result, I had a complete zombie night last night, without even 3 hours of deep sleep before zombieing. Sleep was 2.5/10 (because a zombie night is still more “sleep” than a night on cocaine, which would score 0, as it is total wakefullness 100 % of the time and that’s not what I had. At least I drifted into light sleep with half awake dreams)

The weird thing is, after I take my morning pills (and the other supplements throught the day) I have a completely normal day, full of energy and without fatigue, brain fog or anything. 100 % normal, like pre fin.

I think the Orexin supplement helps with this : lactates and pyruvate prevent glucose from blocking the Orexin receptors. That increase the efficiency of the receptors, Orexin being the main wakefullness and circadian rythm regulation neuropeptide (histamin the secondary one which is why I take anti-histamin to sleep). Sometime in the future I will experiment taking more lactates and pyruvate around 7pm. I will either have a “cocaine night” or my circadian rythm will kick in and tell my brain to transform serotonin into melatonin as a normal person would.

So far, my regimen works wonder for having normal days, and works maybe 50% for nights. Zombie sleep is still a common occurance but it’s unusual to have it all night without at least 3 hours of sound sleep.

#262

That really is interesting, @ozeph, that your sleep can be so profoundly affected by your diet.

I wonder if anyone suffering with severe sleep problems can replicate your experience.

I am most interested in the really simple snack before bedtime that you have had good results with since anyone could easily try that without major planning or analysis. I appreciate of course that if it doesn’t help, it would be worth noting all the other factors you have experiemented with.

My sleep isn’t so bad at the moment (compared to how it has been) and I have recently changed my diet. I’ve had too much going on recently to say if this can be credited however.