I have just had a massively bad experience with milk thistle and wanted to warn everybody to be careful: I only took 6 pills of this stuff, and initially it made me feel really good. After researching it a little more, I found that it is a potent inhibitor of androgen receptor function and stopped taking it. Now, about 4 weeks after taking my last dose, I have crashed, and now am suffering of the following symptoms:
Insomnia: Used to be able to sleep 8 hours without much difficulty, now I wake up after 4 and can’t really fall asleep again
Anxiety: I have not been suffering from anxiety since over 3 years, now I have had anxiety attacks
Brain fog: Didn’t have any more brain fog, now it partially returned
Chest pain: Was much better, now is worse again. Also have a little more gyno.
Depression: Was much better, now partially very bad again
Penis: Now have developed curvature
Hearing loss: Increase in tinnitus
Hair loss: Increase in burning in scalp and hair loss
Body hair: Increase in body hair growth
Energy: General reduction in energy levels
Sexual side effects: Increased somewhat
The by far biggest problem I have now is insomnia. I hope this will go away soon, it took me over two years last time to get my sleep back.
What i found in the literature is this:
So, we’re not talking about an inhibitor of 5 alpha reductase. Nevertheless, I am getting many of the same problems as I originally got with finasteride. This seems to be further proof that ANYTHING which inhibits AR function (be it through the reduction of hormonal levels such as with 5ARI’s), or direct inhibition, as seems to be the case with Milk Thistle, can cause persistent problems akin to PFS.