A total of 626 gene promoters, out of a total of 25,437 queried genes on the array (2.46%), showed significant differential methylation ( p < 0.01); among these, 272 were hypomethylated and 354 were hypermethylated in treated versus control.
Is it safe to assume looking at the Citalopram study that genes of ours have become both hyper and hypomethylated? If this is the case then does the body write a piece of code like software as such to keep these certain genes in this state? So that even the use of a demethylating agent would be useless. Or would they be kept in place because of the overexpression of the androgens receptors themselves that may be driving this condition where the body is caught in a negative feedback loop?