Before I start I’m just going to say these are all my opinions, based on being here way too long.
I’ve read hundreds of theories and it took me years to believe any theory. Nothing has ever made sense to every part of my condition like this.
As it’s been stated here before there a types of PFS. Those who have the most severe type- (no windows, increasing and decreasing androgens worsening symptoms, dont respond to androgens properly anymore) are the ones who tend to agree with this hypersensitive theory. It fits in every way. I feel like those without these markers have a lot more flexibility trying to treat this and I completely understand why they don’t agree with the receptor theory.
This is an oversimplification. If you read the study it goes into the variables and what usually happens when there is an overall decrease in androgens (upregulatution). This is a quote from the study “these results are inconsistent with those presented in the available literature.” Studies unfortunately are not bulletproof. There is always studies that contradicting each other in almost every area. Studies done on rat brains are not comparable to ours or even monkeys. If you read lots of studies you will see these often contradict each other also. Methods, date of study and bias are also huge factors. Whether participants actually has PFS or just took the drug is a huge factor. Epigenetics goes a lot further than just up and downregulation of receptors (these things happen daily). The first study to have covered what we are talking about is Baylor so I’m not sure what all of these studies being talking about are. If I’m wrong please correct me with links.
This is untrue. This has been proven to be extremely hard to do. There are a lot of current studies based on trying to do this with CRISPR.
Same
As far as I know if is one of the main markers to why this is the theory, because the receptors are hypersensitized they continue to downregulate when exposed to testosterone for prolonged periods of time. You have lot of receptors so even if some of them are switched off the remaining receptors will still be doing the job, just not enough to reach your normal baseline.
You’re wrong. Receptors are silenced in many cancers. Hence the use of demethylating drugs. Also its a relatively new thing and hard for anyone to prove especially with rare disease. It could be the reason for a bunch of problems we don’t know about.
Hey Lakehouse, I actually read your story out of interest. I. guess you could say you were a little more lucky than some people here (you still got fucked obviously). My theory for you is still an epigenetic one. Different tissues can be effected differently by methylation etc. It is possible that only the tissue in your brain was effected due to previous epigenetic changes in your life or that you were born with. Just like different receptors in different brain regions can be hyper sensitised to mental or environmental changes. This is also why I believe in this theory so much, because it accounts for a lot of the variation we’re seeing.
