The first Trial with SAGE-217

Do you have brain fog symptoms and emotional blunting aka anhedonia?

I didn’t see you mention it but I want to make sure

Let’s all give it a couple of weeks.

I am hoping for the best for you man.

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I highly doubt it, since they say in the study protocol, that its just there to sweeten the solution…They used the same concentration of sucralose in the placebo group, so its just a masking agent, so noone can tell if hes getting the real drug, or placebo :slight_smile:

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At the beginning, i had a massive brain fog…It was like looking through a tunnel…It was horrible,Add to that continious pictures of me dead, every second i close my eyes (I have seen a lot of dead people, and i couldnt stop imagining myself dead like them…It was like im standing next to my dead body…Its not that i wanted to die, but i wanted this horror to stop, and the only option was to kill myself)…I did have 2 major depressive episodes previously, but I have never ever imagined, that there is something like this horror…Not even a rapist deserves to go through the first 3 months of my crahs, let alone someone who i think at least never hurt anyone in his life like me…Life is cruel…
I dont know, if this answers your question about emotiional blunting, i can tell in that matter, that my whole body is numb (like litereally numb skin, and majorly reduced sensations)…I do enjoy music though, so i dont know where to put myself in things anhedonia…
Brainfog i feel it has lifted, though some days are worse than others

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@silentpain89, whatever the outcome, I just want to thank you personally for taking the risk and spending a non-trivial amount of money to try out this as a means of treatment, ultimately for the benefit of the entire PFS community. You are a brave guy.

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Sorry to ping you.

Any updates?

Have you noticed better sleep?

I’m assuming he would have to wait a few weeks to feel anything a few days isn’t going to do much.

I wrote this as PM to someone here, but i thought i might share it with you all:
Nothing worth reporting till now…I must say, im really not the kind, that feels small changes, as many of the guys here…I really didnt notice anything, till i crashed, though i had lots of symptoms even before that, but the first time i noticed them, was when i crashed hard…I think, me being so is very ideal for such experiment…No trying to offend anyone, but it really bothers me, when ppl start listing details of things getting better or worse like “today i had 10% harder errection than before, or i got some enjoyment while watching a movie, or 5 % more sensitivity on my Penis”…To me it is either im 100% normal or just PFS…And now sadly im still full blown PFS…Thx for asking though

P.S. Sleeping at night is not a problem since i take mirtazapin 30mg…As a child i always took a nap after noon even for 30min, and without i just feel awful, and tired the whole day, and this habit kept with me till PFS…Now i cant take naps anymore…It just doesnt work…And nothing has changed till now

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effects would be noticeable with hours of administration. RIP I guess allopregnanolone isn’t the issue hear…

To be honest this stuff could easily be fake.

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Does it get properly absorbed through the gut and will it pass the BBB to get into the brain, also where did you buy this product from Sage directly? If it isn’t working then we can assume that receptors upstairs have also been methylated.

Ok guys im not trying to be mean or arrogant or anything but there are a lot of misconceptions (Didnt want to use the word ignorance) around here in the forums…One is saying it has to work in hours, the other asking me for the 100 times to inject it in my blood, whether it might be fake, or would it be decomposed in the stomach etc etc…I have already explained, and gone through every detail, and question, that has been asked, and nevertheless 2 posts later, someone comes and asks the same questions…Here is my advice…READ…If you dont want to read, then you have no chance to understand what is going on…There is no way for me to explain everyrthing to every individual on the forum…Im not telling you not to ask, but its becoming a little bit iritatting, when the answer lies 2 posts above the question…Its just lazy, and i wont be answering such questions, or comments anymore…
Please noone should take it personally, cuz i dont mean one person in particular…I really dont, and will never attack anyone who has this condition…You are all my brothers, and i appreciate everyone of you…Take care, and good night

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Well said brother, I’m still hoping you will see some improvement in the next couple of weeks.
Pls keep us updatet if there is something worth mentioning, even if it’s not very positive.

Thank you and good luck!

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Any update silentpain89 ?

I have no idea what is happening if anything at all happening…Im waking with morning errection everyday now, but my anxiety has started to kick in, and im getting the old “out of nothing” racing heart beats, that lasts for 5 seconds and then disappears…Im at a loss to be honest, but im doing the full 14 day course…Im now at day 8 if im not mistaken…I have to check my own post :stuck_out_tongue:

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I am getting the exact same effects from forskolin. It’s weird though shouldn’t allo make you feel calm?

Shit maybe this is it! I hope you continue to see progress!

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I’m sorry if you mentioned it before, but I couldn’t find anything about your symptoms in this thread. Were you having morning erections before? I mean, isn’t having them everyday proof that something is happening? In the 12 years of having PFS, I only remember getting morning erection once.

I’m glad you’re getting morning erections, but aren’t they more testosterone dependent rather than dopamine dependent (the dopaminergic pathway is what may be affected by 217).

Are you having sex dreams and then waking up with wood? This could indicate some type of dopamine induced erection.

Please keep us updated it sounds like something may be happening.