Shit guys…Something is weird, and not good weird…Im feeling im crashing all over again…My anxiety is through the roof…I havent had such anxiety for 4 months now…I can totally see why i wanted to kill myself at that time…Pfffff thing poison is just unreal…WHAT IS THE PROBLEM???..Not even cancer is so complicated as this curse…Enough is enough
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Maybe there’s a nocebo effect going on and you’re worried about the negative sides of Allo / potentially crashing. Try some meditation.
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If I was taking Sage right now then what I would do is maybe write down how I feel every morning in a diary/log but otherwise try to completely forget about the drug and PFS. The reason I say that is that placebo and reverse-placebo effects can be so powerful that they can completely override everything else. I also would take the drug for at least a month. But maybe you had some specific reason to take it for only 2 weeks. But my understanding is that the drug failed a trial that was only two weeks and succeeded in testing that was for longer periods. Anyway, I really would try not to think about things.
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Maybe its causing your emotions to come back ?
Hey silent, is there any chance you can post the packaging so I can see how the drug is presented. Thank you
How do your anxiety levels compared to how you were before PFS? Were you a naturally anxious person?
I’m asking this because since contracting PFS I almost never get anxious. Anxiety in my particular case would perhaps indicate a return to a more healthy state.
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That’s weird I’m the exact opposite. Only anxiety I had before pfs was social anxiety
Hang in there @silentpain89. As a guinea pig, you may just be in the storm before the calm.
Edit: to be clear, I am not advocating continuing treatment, merely stating that the extreme anxiety reaction could pass.
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I agree with Greek @silentpain89 hangin there and push it bro. Since you know the cause of your anxiety disregard it and push it. May be you are reversing some pssd symptoms… all of other guys who tries to reverse their ssri Induced dysfunction reports woods and libido always came back with increased anxiety and depression…
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I also had a huge depression from anastrozole I got extreme joint pains accompanied with unimaginable fatigue and I lost ability to 3D perception of depth… but at same time I got total restoration from pfs for a week… in time all other negative symptoms dissipated with a mild rebound from pfs yet I am better then before… I was thinking about death before aromatase inhibitor trial. Now I have my libido back and will to go on.
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Is there a possibility that there is a withdrawal period from the short-term effects of SAGE-217?
@silentpain89, does the anxiety improve soon after taking it and get progressively worse leading up to your next dose?
Only saying this because I took a potent GABA agonist for its supposed long-term benefits. I felt great for a few hours after every dose (calm, relaxed, more emotional, some subjective increase in libido), but the anxiety experienced for the few hours as it was leaving my system was terrible.
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hi guys…
I just want to thank everyone who wrote to me here in the post or in private…I really really appreciate it guys…It does feel a bit calming to know, that im not alone at this, and someone can really understand what im going through.
As for the concerns (As many has privately stated), that some members are pushing me to do something i shouldnt, i can tell you, that im the only one responsible for what happens, or might happen to me…I would never point my finger to anyone…Im old, and educated enough to know that what im doing is a lottery, where one puts everything he has, and might lose or win…
As for my status now, i can say, that today i woke up much calmer, without the usual “sense of doom”, that i have every morning…I didnt have any morning errection though…So so much for that…
I have decided to go on with the expriment no matter what…I will push through it…I will do the full 14 days, that has been done in the study…
As to the questions that some have asked:
1.I wouldnt go longer than 14 days, as every GABA modulating drug will lead to downregulation of the receptors on the long term, so longer than 14 days would definitely be not a good idea…
2.I have no idea why you would want to see the brown glass vial, that the poweder came in…Even though i have saved it, i dont see the point of posting a picture of it…
3.Im not sure to be honest what was happening this week…I have a very demanding job, and i usually come back from work very tired, and sleep directly for an hour or two pre-PFS…Post Pfs i would still be tired, and wanting to sleep, but just cant…I stay in the sleep/Wake status. till i get bored, and get up and do stuff till the night comes, and i can take my mirtazapin, that puts me to sleep like a baby :D…This week, i was taking the sage 217 after work, and i was literally battling to stay awake after taking it…I fell asleep almost every time, but not for long time, just the usual 45min to an hour that i used to…
4.Im not trying to be arrogant to exclude the possibilty of Nocebo or Placebo, but im 100% sure, that its not both when im talking about that awful heart racing, and sudden onset of anxiety that lasts for 10 seconds, and then goes away…Why am i so sure about it?..Becuz it happens literally out of NOTHING…Without me even thinking of anything…Even when i tell a joke at work, and 100% forget about pfs, or when im really really busy, and talking to many co-workers…I still got that rash on-set anxiety that disappears withing seconds…
5.As to myself before the whole thing happened, i was, and still am a very pessimistic person with latent depression since i was a teenager…I never felt normal, or happy for extended periods of time…But i definitely didnt have any kind of anxiety at all…I had lots of OCD thoughts that were driving me crazy, which just stopped directly after crashing, since i thought that nothing matters anymore, and Death through suicide was my destiny…Please note that im someone with very high self esteem, and even when i had to be hospitalised for major depression, and wanting to kill myself (Way long before PFS, and i really wasnt going to do it), i still had a 100% fighter in me (I was a student at that time, and guess what, i had A to A+ in all exams the same semester, although i was absent for 6 weeks)…I just kept fighting to the last…Even at my darkest hours, i had the libido of a teenager (I dont want to be creepy, or weird, but mastrubation was a very personal time for me, and it felt always good, even when i was at my lowest, i did masturbate 4-5 times daily)…After PFS hit me, i felt broken, the fighter in me went from 1000% to -10000000%…I didnt even know, that such a place exists…Even now writing this, i cant understand how such thing is happening…Its just crazy to think, that i have numb skin, shrunken testicles, genital ansethesia, dry eyes, depression like nothing before and 10 other symptoms…
Enough now, since writing my tragedy depresses me more…I will give you an update in a week…
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Which company did you order this from?
In which country is it located?
Not giving us this info seems a bit like a scam.
Disagree. He has access to a very hard to get substance, anyone who has the ability to do so wouldn’t go around posting the source especially if the source doesn’t want random people asking.
OP, sounds like the naps you take after you get back from work are “restored”
With the rest of the symptoms, asides from the anxiety, it’s hard to understand how the allo would even help, especially with numb skin.
Hopefully you see more progress, good luck.
I’ve learned that neurosteroids that act at the GABA receptor, like allopregnanolone, quiet down neuron activity in the brain, and so give someone an anxiolytic or restful sense of being. That is probably why allo as brexanolone is being used by women with post partum depression–it calms the brain and mind and restores the hormones at the level where it is needed.
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Assuming that we have normal Gaba receptors function…One of my many theories is that after stopping finasteride the Surge of Neurosteroids in particular Allo (Which results in the honeymoon weeks before the crash) might lead to a massive downregulation or altered Gaba receptor composition that in the end cause a full crash as a result…This theory can be simply contradicted by the fact that many have gotten PFS while still on Fin, or by taking it for only few times…Its just so complicated this curse…I cant even start to think How can this poison still be on the market…
Another thing is while SAGE 217 is an analogue to Allo…We cant say that Brexanolone and SAGE 217 is the same, since Allo can be reverted to 5-DHP which definitely has an effect on neurons, and PFSler lack this 5-DHP as well…I think, i might have explained somewhere why i think that supplementing 5-DHP wont be effective in us, since taking 5-DHP orally or transdermally will make it suseptible to be reverted to Progestoreon (5-AR as an enzyme is supposed to be intact peripherally at least, as the harvard study has shown), so one have to take lots of it for it to make its way to the brain…(Again everything is just a theory, and i have 0000 scientific evidence of what im saying)…Thx pharma industry for making another very expensive drug to lenghten the suffering of many cancer patients for many months while they get bedridden with horrible Nausea, and infections…Go ahead and prove its efficacy using numbers, and fancy diagrams to fill your filthy pockets, while playing on the emotion of the public…This just makes me sick…F*ck capitalism
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@silentpain89 I totally agree with you. Capitalism in its current corporatist form is not helping anyone, well, except for the 1% and those who serve them…you can probably guess who I am supporting in the primary election because the rest of em are just more of the same. We can take that discussion offline.
I took Accutane twice without knowing its bad effects. It worked along with finasteride to F me up permanently, especially the cognitive sides.
The chemical behind Accutane happens to knock out alpha-HSD (sometimes called alpha-HSOR), and probably knocks out 5-alpha-reductase like finasteride. So there 2 not just 1 processes in neurosteroid synthesis that have been shut down for those like me who took both bad medicines.
However, and this is a big however, when I take tons of supplemental T via topical route, my DHT level does go up. But despite it going up, I don’t have remission of PFS. So it seems like there is more than just changes or damages to steroid synthesis. Your thoughts?
I think, if and when the theory of not working 5-AR is right, then it would be a problem in sepcific Body organs/Tissue…See even after reducing circulating DHT Levels to 10% of the previous level, almost all of balding men keep on losing hair, and thats because the local production of DHT through adjacent cells keeps on going, and even in the best study result, it was found that scalp DHT levels can be reduced with finasteride to 30 to 50% (And thats talking about whole Scalp biopsies, at the cellular levels, the DHT coencentration in the hair follicle would definitely be greater), a very big deffierence in comparison to plasma levels…If we take into consideration the latest MEclangi study, that showed that PFSler incomparison to normal population (Athough a very small, but ver important study) have methyelated 5-AR 2 promoter, then no matter how much DHT, or Testosteron or ALLO we take, we would never be able to reach local concentration levels that are physiologic…I do believe that its time, we stop all human studies on PFS, and try to force an animal model of the disease…This would be the only way to understand this disease…Take 500 mice or rats, and feed them this poison, and then take the 10 that developed symptoms like us, and dissect them, and do whatever genetic or molecular testing you want…Thats the only way…Working on human, with such little knowledge about the pathogenesis of this curse, would never ever yield result…Our only option in case this theory was confirmed is to find an activator of this enzyme 5-AR, that wont give us prostate cancer in 10 years…Demthylation while possible can never be done specifically to a specific region in the DNA (At least not for now or the next two decades)…Again Thats my opinion, and i have 00 scientific evidence to back it up
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Brother do not think that anxiety only produced by an emotion.
It is a disorder of regulation it can kick in without any reason like depression or schizophrenia… yet it can highly be triggered by neuroactive compounds…
Hang in there we are with you. I also appreciate what you are doing i am also testing various compounds and supplements to end this nightmare generally speaking i am better than before…
My prayers are for you.
Good luck to you and all of us.
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