Please donât stop until you read all.
Our bodyâs immune system identified Fin/Dut as foriegn invadters and produced anti bodies against them but since these chemicals resemble our own natural DHT very much immune system keep attacking our own DHT even after we stop Fin/ Dut/SP.
Auto immune symptoms
look at the list of symptoms and see what symptoms we donât have.
Muscle and joint pain, muscle loss,wieght loss, Candida, sleep problem, Anxiety depression, memory loss, digestive problems etc etc.
evenbetterhealth.com/autoimmune-disease-symptoms.php
Now read the following.
en.wikipedia.org/wiki/Autoimmunity
Molecular Mimicry - An exogenous antigen may share structural similarities with certain host antigens; thus, any antibody produced against this antigen (which mimics the self-antigens) can also, in theory, bind to the host antigens, and amplify the immune response. The idea of molecular mimicry arose in the context of Rheumatic Fever, which follows infection with Group A beta-haemolytic streptococci. Although rheumatic fever has been attributed to molecular mimicry for half a century no antigen has been formally identified (if anything too many have been proposed). Moreover, the complex tissue distribution of the disease (heart, joint, skin, basal ganglia) argues against a cardiac specific antigen. It remains entirely possible that the disease is due to e.g. an unusual interaction between immune complexes, complement components and endothelium.
here is my hypothesis and how events unfold in our system
-When we start using them, some sensitive soulsâ immune systems kicks in and launches antibodies against these chemicals. As soon as We feel adverse effects we stop fin/Dut/SP etc cold turky. Now at this moment our body has high level of tosterone but low level of DHT . We feel better becaue DHT dependent tissues and not under fire.
-After discontinuation of finasteride or dutasteride etc our DHT returns and we feel better but only for a short time. Now body attacks our own DHT, and we start feeling bad and then worse and worse agian.
- Some people restarted finasteride / Dutasteride and again felt better for a short time the reason antibodies were consumed by these chemicals and their concentration goes low and DHT gets a chance to work but again for a short time only , as soon as anti bodies increase these guys begin to feel worse again.
there are many many articles on autoimmune caused by mocular mimicry.
for example
drshrader.com/autoimmune_diseases.htm
this is very good article and highly recommend to read .
what is Molecular mimicry ?
Molecular mimicry is generally interpreted as the sharing of molecular structures (or their protein products) by portions of dissimilar genetic material (i.e. âresemblanceâ or cross-reactivity, most often between different organisms). This produces an âerror in identificationâ by the host. The mimicking material is usually foreign (ânon-selfâ e.g. bacteria) but the material contains components similar enough to certain host cells that the host then mounts an attack on âself.â In other words, a bacteria can trick the body into attacking normal cells that have a few characteristics of the bacteria. When you think a great deal about this, the prospect is frightening.
If a peptide bound by HLA-B27 were the result of molecular mimicry between host and organism, the receptor site would be considered by the host to be âforeignâ. This could easily explain autoimmunity, or the breaking of self-tolerance, since autoreactive cytotoxic CD8 cells could then continue to attack the HLA-peptide reaction site and persist, despite the absence of any initial triggering agent, such as bacteria, virus, etc.
ncbi.nlm.nih.gov/pmc/articles/PMC1011230/
Molecular mimicryâhypothesis or reality?
A number of observations support molecular mimicry as a possible pathogenetic mechanism in diseases such as acute rheumatic fever, reactive arthritis after enteric infection or associated with Reiterâs syndrome, myasthenia gravis, or even in rheumatoid arthritis. Molecular mimicry can be defined as a sharing of epitopes in linear or 3-dimensional presentation on disparate proteins from entirely different sourcesâfor instance, group A streptococcal membranes and human cardiac myosin. How exposure to or infection with organisms sharing molecular similarity with antigens of the human host can evade tolerance and actually induce a self-reacting humoral or cellular immune response is still not clear; however, a large body of evidence has now been accumulated that documents apparent molecular mimicry mechanisms in these disorders
Why I want to know about Accutan?
Accutane has totally different chemical structure.
I repeatedly asked bout accutaneâs reaction with 5 ARs. and how it looks like after binding 5ARs with it?
if after binding 5 ARs Accutane looks like DHT? then my theory is right other wise we are having some thing else
