Intersting thoughts on Epigenetic modifications
I have been looking into the point you made about possible low Allopregnanolone and tetrahydrodeoxycorticosterone with possible high cortisol being responsible for our sleep problems. I am in the middle of doing extensive cortisol testing. So far I have had a middle range normal morning and evening plasma cortisol reading. I have had a normal mid range cortisone reading. I have also had a normal cortisol:cortisone ratio test. This tells me that I am producing the right amounts of cortisol and that proper amounts of my cortisol are converting to cortisone. I will also be doing a multiple time per day saliva cortisol test to get the most detailed confirmation possible that my cortisol levels are remaining stable through out the course of the day. So if everything else comes back normal with my cortisol testing I can logically conclude that if I have an issue with cortisol its at that my GC receptors are either down regulated or up regulated. If this ends up being the case my guess is that I am in low in Allopregnanolone and tetrahydrodeoxycorticosterone which caused the GC receptors to become more sensitive to compensate.
There may be no clear path to increasing 3a-HSD or 3b-HSD but that does not mean there is no path at all. I think that Allopregnanolone and tetrahydrodeoxycorticosterone needs to be tested. I’m taking it that far. I am getting it tested. Hundreds of dollars is worth my life.