I haven’t because there’s no clear path to enhance the 3a-HSD or 3b-HSD complex. It is my understanding that low Allopregnanolone and tetrahydrodeoxycorticosterone with high cortisol is what prevents us from having good sleep and unless we can fix 3a-HSD and 3b-HSD there’s no point confirming that Allopregnanolone is missing.
It costs hundreds of dollars to have those tested, then maybe some supplements can be taken. It would be dose dependent so from my point of view would fix nothing.
Epigenetic modifications can occur for all kinds of reason: a bad long term abusive relationship, pollution in the air, and yes, the very supplements we’re taking to ease our symptoms. There’s no telling if the epigenome will or will not react.
I took fin for 20 years and started having symptoms after 17 years. If I had stopped 10 years earlier, would I have had pfs ? Hard to tell. Than there are those who got pfs from 1 pill. Clearly, epigenetic damage can occur from taking a pill as well as from stopping taking it.
But to me, this is somewhat irrelevant as long as I can deal with the symptoms. The permanent solution, if there is one, is to change our epigenome so it gets as close to a healthy person as it can and for this, I study and use the suggestions given to increase longevity. It turns out aging is more related to excess epigenetic damage than telomere shortening. Anyway, tricks like fasting, intermittent fasting, being in ketosis etc… produce sirtuins to work on the epigenome AND increase the length of the telomeres.
Already I see signs of epigenetic damage supposed to be permanent clearing out: I’ve had freckles on my face from a bad sunburn 28 years ago and dermatologist told me it was permanent. They are now disappearing ! 75% gone already and those are caused by epigenetic damage. I suppose it’s working on the rest on my body as well.