Is the question does Fin/Dut become depleted after becoming part of the 5-ar+NaDP+Fin/Dut complex? (not that this is not an important question because it is)
OR is the question did Fin/Dut temporally becoming a part of the 5-ar+NaDP+Fin/Dut complex cause problems with 5AR and other enzymes?
I was not being sarcastic in my response above. I apologize if it came across that way. I’m not familiar with the theory that was floating around a couple of years ago and I’m not arguing against it or in favor of it simply because I don’t know what the theory is. Instead the point that I was attempting to make is that if the molar concentration of Fin/Dut (and 5-AR enzymes) is entirely insignificant compared to the concentration of NaDP+/NaDPH in any given cell why is it that when Fin/Dut becomes a part of the 5-ar+NaDP+Fin/Dut complex (be in temporally or permanently) do we experience such a large reduction in serum DHT concentrations? The point being if this is how Fin/Dut inhibits testosterone-DHT conversion by becoming a part of the 5-ar+NaDP+Fin/Dut complex it’s hard to agree that this is as insignificant as you suggest if its temporally inhibiting DHT to such a large degree.
Are you saying that Fin/Dut becomes a part of the 5-ar+NaDP+Fin/Dut complex and in addition works as a competitive inhibitor of the 5AR enzyme which explains the actual reduction of serum DHT levels while on the drug? If this is the case than why even make Fin/Dut a part of the 5-ar+NaDP+Fin/Dut complex? In other words why did the creators design the drug to become a part of the 5-ar+NaDP+Fin/Dut complex? You appear to have a background in biochemistry so you are probable a good person to ask. Is this the norm for inhibitor based drugs? To become a part of the cofactor? I have no background in this like most people here so all I can do is read on the internet. But upon doing so I cannot find another inhibitor based drug that inhibits it’s target enzyme by becoming a part of the enzymes cofactor. Am I wrong? I am totally open to the real possibility that I am wrong and hope that I am so I can rule this out and move onto the next.