Trust me man, while there are many medications that can cause actual real damage to the human body and organs, i have never ever seen anything, that is capable of doing such extensive damage to multiple organs, and destroy the lives of a young population of healthy males like this poison…(At least, if a medicaiton caused liver failure of some kind, then it is well understood, what liver failure is…Can anyoone of you tell me wtf is wrong with our body?Ofcourse not)
For crying out loud, i have given many many patients chemotherapy, talking about real poisonous, gene altering drugs, and 90% of them is doing 10 times better than me…
So again, my only concern is that SAGE 217 wouldnt do much to us, neither help, or make worse our situation, and thats my most feared thought
I wouldnt bother to be honest…If you really want to try it, then you have to buy it…(I myself have already spent thousands of dollars on supplements, that didnt even worked, let alone has caused more damage to my situation)…
Yeah I guess so and how many millions of people use chemotherapy in the world?? Literal toxic substance.
You work in the medical field ??
FWIW, finasteride itself is an androgen steroid analog.
Does anyone know what dosage of Sage 217 was used in the clinical trials ?
30mg daily for 14 days
Right. Additionally one of the Traish studies on PFS also suggests that inhibition of neurosteroids can also lead to epigenetic changes.
What have you read to suggest that Zuranolone or exogenous allo can upregulate its own production? Seems plausible that it could since like you’ve mentioned that it’s neuroregenerative.
Could the structural changes be reversed when reintroducing normal levels of allo?
What studies reference this btw?
Just did some research on Allo and I thought I could share. Maybe it should be in a new thread, let me know.
- Allo increases dopamine.
- MOA - B degrades dopamine. MOA-B Inhibitors are: catechins, kava, tonka bean, garlic, mucuna pruriens, sweet grass, vanilla grass, coumarin, coffee and nicotine.
- Progesterone gets reduced by 5ar1 into 5 alpha dihydroprogesterone.
- 3HSD converts 5 alpha dihydroprogesterone (5aDHP) into Allo.
- Sulforaphane increases 3HSD activity.
- NADP+ and NADPH are the cofactors of 3HSD. 3HSD operates in a bidirectional manner, depending on the cofactor oxidative state. The more NADPH, the more Allo can be produced from 5aDHP. The more NADP+, the more 5aDHP can be produced from Allo. Niacin is a good source of these cofactors.
- NADPH oxidase will convert NADPH into NADP+ and superoxide. This leaves the system with less NADPH and more conversion of Allo to 5aDHP. To increase Allo, we need to inhibit NADPH oxidase.
- Superoxide is a powerful antibacterial. I believe our PFS bodies produce a ton of this. This is why we do not get sick anymore (cool benefit) and could be the cause of gut disbiosis. Superoxide increases ROS and can cause severe damage. It should be kept low unless we are sick.
- Cool fact, keto massively upregulates Superoxide dismutase. One of many reasons we feel better on keto.
- NADPH oxidase is upregulated by inflammation such as IL and TNF alpha. Alcohol also increases NADPH oxidase. Alcohol is known to decrease Allo. Also note that inflammation from TNF alpha will cause methylation of the 5ar promoter enzyme.
- Apocynin and Nitric oxide inhibit NADPH oxidase, which is what we want. This could explain why viagra and cialis make people feel better.
- Side fact, glucocorticoids and DHEA increase Allo.
- Side fact 2, keto diets inhibit HDACs globally via butyrate and BHB
Wonderful! Thanks for sharing!
This may explain why some people get better after using progesterone gel?
Interesting as I spoke to Dr. Rogawski who created Brexanonolone and he said it does not lose effectiveness after 30 days.
Since it’s an analog of allo I’d assume that like most testosterone/dht analogs it won’t produce any kind of tolerance
What are some T/DHT analogs?
Allo itself doesn’t seem to cause any tolerance in hypnotic effects (promotes falling and staying asleep) when administered to rats for 5 days straight, unlike benzodiazepines: https://www.nature.com/articles/1395685
Many of the commonly known anabolic steroids on market. Deca, dbol, tren, mastron etc… It should be noted that many people experience permanent side effects (personality changes, changes in response to other drugs like Clomid) after taking some of these substances, the main one being tren. probably because tren is so powerful…
I think if it cut off allo productions in normal level healthy people, then the folks with normal allo levels in mild depression that took sage, would then have trd depression instead of mild because it would cause their allo levels to crash
Yeah those don’t seem like good example of not producing tolerance. Deca dick etc. people get rekt on those.
Actually, now that I think of it and read a little, it does seem like “Deca Dick” and PFS are maybe the same thing. Discussion of neurosteroids and Deca Dick
Correct me if I’m wrong, true the symptoms might be the same but I’m pretty sure Deca dick is fixable with TRT.
Its not. I have a friend with deca dick. He can take 2 gram of test does fuck all too him.