Reversing Gene Expression back to Normal

General Discussion
#45

I took it since I quit fin. And took it before that but irregularly.

I can’t say if it actually changed my pfs state, but I can say I don’t have alot of issues with anxiety. But it really depends weirdly enough on the situation.

It’s still definitely worse then before fin. But alot better then right after quitting fin.

I die have maybe 2-5 days without nac right after fin, but can’t pinpoint if the change has been due to nac or any other of the 10 supplements i take.

Whenever I have a sharp headache I take GABA with L theanine. Which happened often right after quitting fin, first two weeks or so. When I had trouble sleeping before pfs i took it as well. Gaba affects the the same pathway as benzo’s. Can’t say by what exactly but you should pook it up.

In have no issue sleeping, only the dreams disturb me sometimes. But the sleep itself isn’t bad.

The issue is: I can’t measure what benefits I get from it. Before fin I didn’t see any results that where cognitively obvious. But got it recommended to improve liver function on a bodybuilding discor d.

I trust that by improving liver function, by increasing gluthathione, a lot of side effects that would worsen could improve.

#46

Anxiety and insomnia are very common side effects of pfs. According to the action mechanism of NAC, it could prevent those but who knows ?

I know that I can take only very small doses of NAC because I’m on benzos. 100mg is like I’m on drugs and that drug is probably the benzos. But again, who knows ?

Thanks for your post !

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#47

and do you think we can change our epignome to repair fibrotic tissue in penis caused by dut/fin apoptosis?

#48

The body does amazing things. My sister had blocked arteries to the heart and needed a bypass. During the operation, the doctor discovered that a natural bypass had been formed on another part of the heart. Small veins had grown and turned into arteries to irrigate the part that was blocked. It’s a rare occurring phenomenon, but it saved her life.

I have no answer to your question. I don’t know. But it’s worth trying IMHO, especially considering the other benefits from repairing our epigenome.

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#49

you see im familiar with these cases of vascular networks developing to save the life. its really a hopeful thing to know about, and im glad your sister was saved with this mechanism. I wonder what sort of requirements are needed to trigger this sort of regeneration

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#50

Well, neuroplasticity of the brain can do wonders too. We just need to find the way to access it.

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#51

I have further progress. My sleep keeps improving, my eyes are not burning anymore (a first in 7 years, which is 4 years before I crashed) and my lips are still dry after a shower, but much less so.
My body odors returned naturally without androgenic herbs. Although they seem to fluctuate, it’s also a first since I crash that I can have body odors naturally. And my morning woods don’t wake me up much. I wake up 3-4 times in the morning, very drowsy, and go back to sleep right away compared to 2 years ago when I would either not go back to sleep or wake up more than a dozen times. I reduced sleeping herbs.
Anhedonia is gone. This one is only noticeable when it comes back ! I constantly sing in my head, it’s nice !

Unrelated, my freckles. which are the result of epigenetic damage to my skin after a heavy sun burn 31 years ago, are 80% gone. A dermatologist told me I would have them for life, there’s no treatment (except repairing the epigenome, but how a doctor would know that ?)

I’m 3 1/2 year post crash. I’m confident I’ll be fully recovered by the 5-6 years mark.

I wish you all success !

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#52

Further improvements: Morning woods don’t wake me up anymore, I have full nights. My lips are a little bit dry after shower but I don’t require Vaseline anymore (a first in 7 years, which is 4 years before I crashed). Body odors are firmly set. eyes still not burning.

Last improvements were posted 15 days ago. I’m improving faster then I thought.

I still sometime have high glutamate before sleep, which seems to correlate to having done more weight lifting and/or having had sex. I think it’s due to elevated androgen.

I’ll wait a little more and maybe attempt tapering sleeping meds.

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#53

have you been on a keto diet without interruption all this time? what dose of benzo are you taking?

#54

I was reading up on epigenetic drugs last night, and I found out that short chain fatty acids are used as epigenetic drugs: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4251063/

“Similar to HDAC proteins, HDACi are also structurally diverse. HDACi can be categorized into several groups according to structure, including short-chain fatty acids, hydroxamic acids, epoxyketones, and benzamides.”

Which is interesting because some members on this forum have experience positive effects from butyrate supplements, and butyrate is a short chain fatty acid: Review to an old topic " The gut microbiome "

#55

@gabriele Three years and a half on a ketogenic diet. I"m taking 3.5mg of clonazepam once a day before sleep and I really wish to stop.

@RockyMountaineer : This is very interesting indeed. 80% of the ketone bodies produced while in ketosis are BHB, which is Beta-HydroxyButyrate. I get more than 100 gr of BHB a day. Butyrate or butyric acid changes into BHB to be used by the body as fuel. But it has many other properties.

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#56

If you want to try to stop benzo in the right way, send an email to him beatingbenzos@outlook.com
Told him your benzo story and ask for a taper plan, also read the ashton manual.
Usually he made a taper plan like 10% every 4 weeks, but for every body is different, i hope him can help you, ciao

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#57

I have a question also, did you notice an improvement on sleep with one or two weeks no fap?

#58

I can’t say I noticed. I may have slept better with faping but I was also sleeping good before I started faping again.

Things are moving faster for me. I did 2 months no faping, sex drive went up, I faped once and then everyday after that. Sex drive is definitely up but not at previous levels yet.

Thanks for the contact for stopping benzos ! I will stop the benzos first before the sleeping herbs as benzos interfere with a glutamate blocking amino acid that works very well to treat high glutamate insomnia and does nothing for other types of insomnia.

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#59

I’m gonna DM u

#60

Update: My 5ar keeps rising. Sex drive is getting stronger and I feel turned on by girls on the street, even though they may not be that pretty, and that’s a first since I crashed. I could tell a girl was pretty, but I wouldn’t get aroused like I do now just by looking at pretty legs. Sex life is back to normal.
My lips are not burning at all anymore but may feel a little dry after shower. Eyes are fine. My hair have started falling and they’re now falling faster. (If I go bald, I’ll grow a thick beard !)

On the other hand, morning wood are waking me up again, they last for hours and my sleep is getting worst. That sometime gives me brain fog and makes it more difficult to function normally. My guess is that my DHT is increasing and my AR are still too expressed (sensitive) for this higher level of androgen I’m now having.

One might see a regression but I think having more 5ar and DHT is a move in the right direction. My body just needs to re-balance to the higher androgen environment. I still eat ketogenic and do tricks to repair the epigenome as I believe it contributes. I crashed almost 4 years ago. No doubt time has been a major element for the improvements.

I’m the eternal optimist. I believe !

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#61

What would you say the most helpful thing towards healing was? I remember you were on carnivore

#62

How do you know your 5ar enzymes ‘keep rising’?

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#63

In my opinion, the ketogenic / carnivore, one meal a day diet helped the most. However I can’t say 5ar came back because of it. I believe time did that but I will never know why it came back…

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#64

5ar makes hair fall. But really I can’t prove anything because I didn’t test.

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