Rb26dett Story with 5-HTP

Welcome to our community. Please fill in the following template as a way of introducing yourself, and helping others to understand your background and situation.

Where are you from (country)?

How did you find this forum (Google search – if so, what search terms? Via link from a forum or website – if so, what page? Other?)

What is your current age, height, weight?
March 1993 (25), 1,68 meters, 54kg

What specific drug did you use (finasteride, dutasteride, saw palmetto, isotretinoin/Accutane, fluoxetine, sertraline, citalopram, leuprorelin, etc…)?
Paroxetine and 5-htp

What dose did you take (eg. 1 mg/day, 1 mg every other day etc.)?
Paroxetine from 2012, started on 20mg, from 2014 5mg. I never had problem with Paroxetine. On august 2018, my neurologist advised me to take 5htp. I took 200mg for “just” 9 days. My life is ruined.] 66

What condition was being treated with the drug?
Panic attacks

For how long did you take the drug (weeks/months/years)?
. Paroxetine from november 2012 to september 2018
5-htp from 6th august 2018 to 15 august 2018

How old were you, and WHEN (date) did you start the drug?
paroxetine 19 yo
5-htp 25 yo

How old were you when you quit, and WHEN (date) did you quit?
25 yo

How did you quit (cold turkey or taper off)?
paroxetine taper off, 5-htp cold turkey

How long into your usage did you notice the onset of side effects?
after 3 days of 5-htp

What side effects did you experience that have yet to resolve since discontinuation?
ED, loss of libido and sex drive, weakness, testiucular pain, penis pain, anxiety, diarrhea, liquid sperm

Check the boxes that apply. You can save your post first, then interactively check/uncheck the boxes by clicking on them. If your symptoms change, please update your list.

[x] Loss of Libido / Sex Drive
[x] Erectile Dysfunction improve if i take Tadalafil 5mg
[ ] Complete Impotence
[x] Loss of Morning Erections improve if i take Tadalafil 5mg
[x] Loss of Spontaneous Erections
[x] Loss of Nocturnal Erections improve if itake Tadalafil 5mg
[x] Watery Ejaculate improved before 2 months, sometimes come back
[x] Reduced Ejaculate improved with time, sometimes come back
[ ] Inability or Difficulty to Ejaculate / Orgasm
[x] Reduced Sperm Count / Motility improved with time

[ ] Emotional Blunting / Emotionally Flat
[x] Difficulty Focusing / Concentrating
[x] Confusion
[x] Memory Loss / Forgetfulness
[ ] Stumbling over Words / Losing Train of Thought
[ ] Slurring of Speech
[x] Lack of Motivation / Feeling Passive / Complacency
[x] Extreme Anxiety / Panic Attacks fixed with clonazepam
[x] Severe Depression / Melancholy
[x] Suicidal Thoughts

[ ] Penile Tissue Changes (narrowing, shrinkage, wrinkled)
[ ] Penis curvature / rotation on axis
[x] Testicular Pain
[ ] Testicular Shrinkage / Loss of Fullness
[x] Genital numbness / sensitivity decrease started on march 2019. Never before
[ ] Weight Gain
[ ] Gynecomastia (male breasts)
[x] Muscle Wastage
[x] Muscle Weakness
[x] Joint Pain
[x] Dry / Dark Circles under eyes

[x] Prostate pain
[x] Persistent Fatigue / Exhaustion
[ ] Stomach Pains / Digestion Problems
[x] Constipation / “Poo Pellets”
[ ] Vision - Acuity Decrease / Blurriness
[ ] Tinnitus (ringing or high pitched sound in ears)
[x] Hearing loss
[ ] Increased hair loss
[x] Frequent urination fix when i take Tadalafil 5mg
[x] Lowered body temperature

[ ] Other (please explain)

What (if any) treatments have you undertaken to recover from your side effects since discontinuation of the drug?

If you have pre or post-drug blood tests, what hormonal changes have you encountered since discontinuing the drug (please post your test results in the “Blood Tests” section and link to them in your post)?

Anything not listed in the above questions you’d like to share about your experience?

Tell us your story, in your own words, about your usage and side effects experienced while on/off the drug.
I took Paroxetine for panic problems. I have never had too strong adverse effects. Only in the early days, it made me sweat. For over five years I took Paroxetine and I could also stop it without side effects. One day a neurologist suggested I take 5-htp. Since then, my life is over.


The neurologist suggested you take 5-htp alongside Paroxetine? From what I understand taking 5htp with a SSRI could increase the risk of serotonin syndrome.

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He told me that it is free of side effects and that it would help me with my anxiety.

Sorry to hear thar you are syffering that way! Yeah… That makes me think this condition should not be called PFS. You see, you never took Fin or Propecia and you have the same symptoms as others. I had the same symptoms as yours when I crashed and I took only Minoxidil for 6 months and Saw Palmetto for 2.5 days.

A sign of an anti-androgenic effect of 5-HT itself is discussed in this post, with the first study linked and first paragraph specifically discussing 5-HT receptors.

Also recently witnessed a friend have a very bad (temporary) reaction to 5-HTP taken after only a few (3-4) alcoholic drinks, involving dizziness, disorientation, vomiting, and swollen eyelids. …She looked heavily stoned. This stuff is far from harmless.

In your opinion, is there anything I can do? My prolactin levels are high and my free testosterone is very low. What could I do? I have already tried citrulline, mucuna pruriens, aspartic acid and zinc, but the situation continues to worsen.

i took minoxidil orally and nothing happened. took propecia and brain fog started immediately

Dunno about you, but I noticed some strange stuff going on while taking Regaine… I didn’t pay attention at the beginning though, stuff like, some days I had absence of morning wood, and at the end of the usage I noticed that when I have extended sexual activity my legs hurt like I had flu for about 10 minutes after that. Then I took SP and got the sides on the second day. That makes me think the Regaine set me up for the final crash that fucked me up. My fault that I believed this shit is harmless. It is not apparently. It is my opinion though, so you don’t have to share the same opinion.

ok . no problem. my opinion is that minoxidil cant cause and endocrine system crash. so yes you could have sides but they go away when you quit. more likely that saw palmetto was the cause of your disease

That could be the case bro! I could only guess at the moment what led me to this condition…

My humble opinion is to give it some time before throwing treatments at the problem and risk worsening the situation. Most naturally recover somewhat in the early months to 1year mark. If you are DX’ed with high prolactin or low T, treating those issues might (also might not) help.

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Hey man,

If I were you, I would try TRT out. Your free T is low, is your total T low as well? Get a hormone panel done with sensitive estradiol test and figure out what your bloodwork looks like. Also, check out thyroid. How high is your prolactin?

In PFS, most people do not respond to TRT. It’s almost like it is treatment resistant. In your case, you may respond to it, or you may not. Your case could simply be hypogonadism, from antidepressants and not typical PFS. For example, my test and free test are both pretty solid. Total test is in the low 700s/high 600’s range. For me, it does not make sense to try TRT because my levels are already excellent, and it is clear that testosterone is not the issue.

Get an overall picture of what your hormonal situation is, including thyroid. And remember, a doctor may call you normal with a “350” level because you fall in the range of the lab, but that is still low.

In recent months, I have tried Mucuna Pruriens, Citrulline, zinc and aspartic acid … Unfortunately, contrary to my expectations, testosterone decreased and prolactin increased. Tomorrow I will go to an andrologist, but now I have little faith in the doctors …

What mean DX? Sorry, i’m not English…

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It’s short for diagnosis. If you trulu ha e high prolactin and/or low T, treating those might help.

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jump on JQD protocol
only proven to work
-test enanthate


And have you done this yourself?

What is JQD protocol?

Hi! You have exactly the same symptoms as when i crashed with Paroxetine. We re waiting you also on http://www.pssdforum.com/ .
Thank you for your posting and we are very sorry for you. Neither to the greatest enemy i don’t want what we have passed.

@iull1k Hello, I’m also registered on PssdForum, but I think it’s more important to be all together (PFS, PSSD, PAS etc …) on a single forum and this seems the most complete. I think the substances that created the problem are different, but the problem is the same.