I really thought I stumbled upon something significant until finding out that EGR1 seems to mainly promote survival and growth of androgenic tissue in the absence/deficiency of androgens. …It does not appear to be directly involved in modulating sensitivity to androgens by promoting overexpression of the AR, as would be expected of a gene/protein involved in PFS. Though, it could achieve reduction in the transcription of androgen-activated genes by reducing the positive effect SP1 has on activation of AR-target genes. That might sound like a confusing mess, but what is important is that EGR1 alone is not sufficient to cause AR overexpression. I would need to know more before commenting further.
If anything, it is likely to be a simple marker of an anti-androgenic effect of these drugs. This is also assuming serotonin (SSRIs) and Accutane don’t increase EGR-1 expression via a different mechanism that has nothing to do with an anti-androgenic effect.
A biopsy would need to be taken from affected tissue and our EGR1 levels would need to be compared against the same tissue in a control group. This ain’t gonna happen.
The pharmaceutical industry can’t possibly be that evil or powerful, right?
Excerpt from interview with the discoverer of H. pylori as cause of stomach ulcers :
That letter must have provoked an uproar.
It didn’t. In fact, our letters were so weird that they almost didn’t get published. By then I was working at a hospital in Fremantle, biopsying every patient who came through the door. I was getting all these patients and couldn’t keep tabs on them, so I tapped all the drug companies to request research funding for a computer. They all wrote back saying how difficult times were and they didn’t have any research money. But they were making a billion dollars a year for the antacid drug Zantac and another billion for Tagamet. You could make a patient feel better by removing the acid. Treated, most patients didn’t die from their ulcer and didn’t need surgery, so it was worth $100 a month per patient, a hell of a lot of money in those days. In America in the 1980s, 2 to 4 percent of the population had Tagamet tablets in their pocket. There was no incentive to find a cure.
Nearly everyone on this site can understand your negativity, but repeating it endlessly does no good in any way.
If you read that article I linked, you’ll see that the good guys, and the public, won eventually.