I hope I recover as quickly as you have. I ordered some progesterone today and I’m getting my blood tests tomorrow. I read your story, Chi’s, and other recoveries almost every day to try to muster up some hope for my situation. I hope with all my heart I get lucky, but I didn’t get lucky not getting sides, or having them go away with continued use, or having them stop when I stopped the med, so it’s hard.
Light at the End wrote
Also,
So, reducing (though not easy) chronic psychosocial stress and progesterone cream may do the trick?
What do all these neurosteroid studies have in common? The answer…they all use finasteride to destroy the protective effects of progesterone and to reduce Allopregenalone.
Second Amendment, it’s been about a month and a half since you last updated. How are you doing with the above protocol? Any changes, positive or negative? If you can, perhaps update with the 1-10 scale that you used last time.
livestrong.com/article/12864 … gesterone/
oh boy people, what can an imblance or low progesterone in the brain potentially do? Yes thats right, leads to depletion of the neurotransmitter serotonin and lead to inability to ward off depression.
Whats interesting is that I feel the depression cycles, meaning it can be bad for a few days to a week and then gets much better.
Well guess what? Progesterone is one of the few hormones that cycles.
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Finatruth, I notice you tend to cling to this “progesterone imbalance theory” in all of your posts.
Rather than endless googling about pet theories, please consider investing your time into more productive efforts such as actions to generate media awareness of PFS, and driving donations to www.pfsfoundation.org for research initiatives.
My symptoms have flucuated.
I’ve been suffering from persistent Propecia side effects since 2005. I’m still doing the protocol but my symptons still flucuate. Andractim once every three days plus aerobic, anaerobic, and resistance training five times a week have helped. I’ve made improvements but keep in mind, I am still suffering from Propecia side effects and have been since 2005.
Second Amendment, your profile indicates that you started propecia in 2005 and stopped in 2011. Did you have sides since your first pill? If so, why did you continue so long?
I took it off and on as stated in my Don Lemon interview. I had persistent sides the first time but didn’t attribute it to Propecia because I believed Merck’s warning label that all side effects would resolve upon discontinuation. Only when I took it again and the side effects amplified, then I did some researching and found this website, the incongruous warning labels between US and Europe, and Velocity’s story did I attribute my persistent problems to Propecia.
Mew, I dont know if my last post went through. In 2008, while still on fin, I took a cruise for a week. When I got off the boat, I could feel the rocking of the boat for…almost 2-3 years! It is an extremely extremely extremely rare disorder and primarily affects women in their 40-50s pre-menopausal. It is called Mal De Debarquement and for years they were unsure if the cause was innner ear, neurological, some type of migraine variant. Finally a doctor, smart enough to realize this was affecting a speficic gender and age group, decided to test hormones. What was discovered was an imbalance of progesterone to estrogen in the brain. One patient actually reported an immediate cesation of the rocking feeling on HRT. Now, leading reasearch is looking at an imbalance of progesterone to estrogen in the brain.
Now, wouldnt it be an amazing coincidence that I have this syndrome unrelated to my finastride use? It is also a coincidence that we are experiencing symptoms of estrogen dominance or low progesterone, which is exactly what they are studying now for the disorder. It is also a coincidence that finasteride is KNOWN and USED in these neurosteroid studies to ABOLISH the protective affects of progesterone. It is also a coincidence that some people reported getting better with long term use of progesterone, It is also a coincidence that such an imbalance would explain every major symptom we experience, lets call this the “single bullet theory” It is also a coincidence that many people have reported that they have family members that are low in progesterone (myself included) This could just be a lot of coincidences, but I personally dont believe in coincidences.
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Second Amendment- thanks for the reply. On the first round of side affects were they more mild in nature? slight ed or some lack of libido? Did you then or later have the full hormonal crash? thanks
Finatruth, the gene expression research going on can explain persistent neurosteroid problems as well. Either way, why don’t you continue with light at the end’s progesterone protocol and let us know how it goes. If light at the end recovered via that method, then maybe it is after all only neurosteroids as you claim. If that is the case, we should be seeing multiple success stories from that same protocol.
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Dgreene- wait a second they could possibly be related. I have read that progesterone can regulate neural cell proliferation in both the peripheral and central nervous system. Progesterone can increase the expression of genes that enhance cell division and inhibit the ones that repress it!!! This is it people ! This is the final piece of the puzzle! Knockout progesterone as you inhibit the expression of genes!!
So then why not supplement progesterone, as light at the end did? If I recall, you had taken progesterone for five days a month or two ago and reported extremely positive results. If you’re so convinced of your theory, and saw such progress in such a short time, why not continue with the treatment? I’m not saying your theory is wrong or right, but seemingly every single one of your posts maintains a borderline obsessive focus on this theory as the sole answer to our problems, yet you yourself are somehow unwilling to test the theory yourself. If you want to test on yourself, great; I’m sure many guys here would love to hear the results. If not, when deciding to post, at the very least you could provide links to actual scientific journal articles that shed more light on your theory, and not to websites like livestrong.com, which has absolutely no credibility, scientific or otherwise.
I’d say less severe rather than “more mild” as I didn’t have muscle wastage or joint pain. I’ve had persistent side effects since I first took Propecia but completely bottomed out and stayed there for nearly a year the second time around.
Clampdown- I did start 3 days ago. However I am not convinced the delivery method and amounts are correct. I u look at all the studies using progesterone on the brain, it is delivered intravenously or by nasal pump.
Finatruth, I would target the androgen dependant zones of the spinal cord, not directly the brain, at least not to start with. For this sake, you can deliver the progesterone anally as someone already tested, but I think transdermally will be fine. Having a read of your progesterone and 3a-diol-G might however give you some indications on the dosing needed.
To clarify has anyone except light at the end had sustained success with this intervention??
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19, I am having a strange experience with it. The first time I used it about 3 months ago I did it for 5 days and stopped bc I didnt think it was helping…I felt more dryness, brain fog, and reduced sexual ability. However, I rebounded in a 2 week period and actually increased my PFS baseline. Prior to use, I had trouble feeling orgams, but that seemed to go away. So I tried it again, 5 days use. Same thing, got more dry, face got really red, reduced sexual function etc. Now I have stopped so I will report in a couple of days/week if there is some sort of rebound affect that I previoulsy expereinced.