Progesterone treatment?

Therapeutic Efforts Pharmaceutical
#926

I think so yes, and prayingtoheal. youre right, Im not saying that people got cured with progesterone alone, but there are about 10 people saying that it had a positive effect for them so we can’t deny that and i dont think that’s strange if the research told us were lacking it in our brains. it is more important in the brain than testosterone because it regulates more neurosteroids/gaba etc. and it is needed for sexual health. it seems that the synergetic effect of progesterone with testosterone has better effect than test or progesterone alone. i think all people who got cured on this forum did not use only one thing but a comprehensive protocol of many components, else we would have known the answer for a very long time. my guess this isnt estrogen dominance alone, because estrogen dominance alone is a problem but our situation is much much more severe. estrogen dominance isn’t very rare and a lots of people who got this do not have suicidal thoughts etc.(the problems we have) there has to be more to it, but it is part of our problem. people respond to anti estrogens just like they do to progesterone (the research about neurosteroids make this logical). there are also couple of people who got better using thyroid hormones, or focussing on the adrenals ( one story i have read even recovered supporting thyroid with hormones ) that makes me think this is a problem that goes deeper than an imbalance in the brain (although the brain makes us feel like we do, so this is the finish line of our problems). the shrinkage problem for example , that many others here got, is in my case from very low body temperature that i got overnight after my crash. so the crash probably fucked my thyroid in one night. think of your dick in a cold swimming pool, it shrinks. i had several small recoveries by just sitting in the sun. this is i think a major endocrinological failure, something in our body keeps us from recovering and it’s not simply addressing one issue in my opinion else we would have solved this. the adrenals are responsible for our progesterone production, so somehow they are not functioning right (probably because of thyroid problems/cortisol), and i don’t think that’s very strange because we stressed our adrenals big time during crash. the thyroid and adrnals are working close together so you get problems there too. also do not think this can be androgen insensitivity, because else people wouldn’t feel anything from testosterone but there are some that do. about deca im not sure, progestin is a synthetic version of progesterone and in big amounts it is used for sex offenders (it is different because natural progesterone do not have this effect), but you could be right i dont know.

-he role of progesterone has been severely underestimated in men. Depending on the stage of a woman’s menstrual cycle, men can have just as much progesterone in their bodies as women. Most scientific studies have focused on the effects of progesterone on women, and its role in men has been neglected. It’s only recently that scientists have started to realize how important this hormone is in men.

-the latest studies suggest progesterone is just as important as estrogen and testosterone. In fact, progesterone is a precursor to both of these hormones (meaning both estrogen and testosterone are produced from progesterone), so it plays a big role in deciding the levels of these hormones. Where guys with man boobs generally have high estrogen and/or low testosterone, progesterone works, in part, by lowering estrogen, and raising levels of testosterone.
Read more: chestsculpting.com/progesterone- … z3NKlP7zUN

-As men age, complaints of weight gain, loss of libido, and prostate enlargement top their list of health concerns. Many physicians and scientists are becoming more aware of a common link between these symptoms and conditions. That common link is often an imbalance between two sex hormones, progesterone and estrogen.
-Progesterone is a key precursor to other steroid hormones, including cortisol, testosterone, and the estrogens (estriol, estradiol, and estrone). When progesterone circulates in the blood, 90% is bound to a protein or albumin fraction. Only a small percentage (3%) circulates unbound.4
-The term “estrogen dominance” describes the condition of lacking sufficient progesterone to counteract the effects of estrogen. A common misconception is that estrogen dominance results only from extremely high levels of estrogen. To the contrary, this condition also may be caused by normal levels of estrogen and relatively low levels of progesterone, or by low levels of estrogen and extremely low levels of progesterone.lef.org/Magazine/2006/4/repo … ne/Page-01

2 Likes
#927

Here is more evidence. A journal article in which dermatologists saw a ton of finasteride users developing Melasma. They theorize a problem with progesteone/estrogem imbalance. Here are 3 articles highlighting this

europepmc.org/abstract/MED/24719069

link.springer.com/article/10.100 … 014-1466-5

sciencedirect.com/science/ar … 1714000548

#928

Wow, all my brilliant theories of 2-3 years ago are now being recognized!! Boooyaaaa!!!

#929

I think I may know what’s going on with me and what I’ve been doing lately and why i’ve seen results.

The picture posted below reminds us that progesterone increases the sensitivity of androgen receptors. Let’s keep in mind that a receptor can either be taken up by estrogen or testosterone, not both ; well if we use progesterone to make those receptors more sensitive but at the same time there is too much estrogen floating around then we just made our body pick up even more estrogen than before we took progesterone which explains why people feel bad on it… But, if you first take free testosterone boosters along with an AI to cut down on the estrogen and THEN take progesterone to make your body more sensitive to hormones, there will be more testosterone to bind to the receptors instead of estrogen and you’ll experience what I have, feeling better all around. I had just completed a cycle with an AI to get rid of some of the estrogen so this all adds up for me.

taking a higher dose of progesterone will make the receptors even more sensitive and also help cut out the estrogen.

So in a nutshell, get rid of excess estrogen, boost free testosterone, then in this window of opportunity use high dose progesterone to re-sensitize the androgen receptors.

I’ll add that I went back on the AI yesterday and today to test and positively felt the first increase in libido any protocol has ever given me.I needed sex yesterday and today again which rarely, if ever happens to me. This won’t mean much to me unless it continues, I’ll keep updates coming,if things happen as they usually do I can expect a crash in a few days.

#930

I enjoyed this, thanks for the info

#931

great thinking brongfogboy. the receptors could be indeed down regulated because of high estrogen in a defence mechanism. plus if progesterone sensitizes the receptors and you got estrogen dominance (what means you got low progesterone), receptor sensitivity is already low. you add some progesterone, sensitivity goes up, so feel worse because of the high estrogen levels.

if you put the three theories (androgen insensiviity, estrogen dominance, low progesterone levels) together you get a pretty logical explanation of our situation, confirmed by research, symptoms and how we feel. because of our depleted progesterone levels in our brain we get estrogen dominance and desentisized receptors. brain scavenged for progesterone because of high testosterone so high estrogen, low dht so more progesterone needed to counter estrogen, altered cholesterol so decreased progesterone production, and disturbed 5ar so decreased progesterone metabolism and its metabolites, dihydroprogesterone and tetrahydroprogesterone plus high need for cortisol(close adrenals/thryoid connection) which also strips progesterone. if our brain cannot even fully detect we are in this situation, how can it restore normal body function. The night of my crash i was feeling a kind of headache, which ive never felt before ( i never have headaches anyway). normally our body protects our brain as last to keep the whole body functioning, if it got drained from progesterone and important neurosteroids somehow, it could dramatically affect dopamine production and change the brain so our whole body. I always had a very clear mind and thinking, but during finasteride use it became worse and when i stopped it ,extreme brain fog/anxiety kicked in, concentration gone, very confused ,sometimes dont even know what to say etc. in one night. but indeed its just a theory. im very curious how youre experiments will go, please keep us updated.

-In another rat study, they mimicked the damage done by a stroke on the brain. Rats given progesterone after the stroke had significantly less damage and had more improvement in function afterward. In that case, progesterone protects the brain and nerves and may even help them regenerate.(13, 21) Progesterone can reduce cerebral edema (21) after an injury too.

-Progesterone can help clear the brain fog. Dr. Collins thinks that one of the signs of progesterone dropping too low is in fact a sense of confusion.(35) One preliminary study showed that postmenopausal women did better on some brain tests when they were on estrogen plus either progestin or progesterone than on estrogen alone.

#932

This all makes A lot of sense, when I used profesterone I defintely felt like I was re-sensitizing the receptors

#933

I think you guys are hitting the center of our problem, congratulations.
I also think that we need to remove excess estrogen, I don’t know if progesterone would do it but maybe os bile or any bile acid should help in this process and I just read that high fiber diet helps to remove excess estrogen.

The only protocol that I felt better was 2 weeks on tribulus low dosage then started progesterone and felt worse, then I increased tribulus because I was desperate, then I stopped thinking it was just the cream that helped me. I think I was wrong. I can say that I felt the up and down and got better right after. My personality returned, my emotions, energy, no more brain fog, no more depression, got morning wood back, better sensitivity in my penis, better orgasm, no more gynecomsstia and reduced pot belly.

I think first we should respond to test-boosters and when our body gets working it will be time to remove estrogen. After each cycle we will have less estrogen, more AR, maybe beekay felt better when he used tamoxifen because it binds to the ER.

If justquitdut is a real person and really commited to pfs, he should stop all hormones and help us here.

#934

male to females inject estrogen too much why dont they experience pfs like symptoms? bcs of low prog/est ratio?

there are nice reads about female to males who are using pogesterone and testosterone…intrtesting…

#935

Progesterone… They give this to guys that want to become girls. I guess you guys are just trying to finish the job. :laughing:

#936

mcbifiboth, Adult males have levels similar to those in women outside pregnancy so i do not think you’re right on that. progesterone is even made by the testicles. sure, transgender get progesterone added to their treatment because of the high doses of estrogen. if they dont do that they havet a much higher chance to get prostate and other kind of cancer and all sorts of other estrogen related diseases. transgender even take it for their libido, but that does not say it is feminizing because they are still men. below something about an endo with 20 years experience.

My endo who is also my gender therapist (she has twenty years of experience with Transgender people BTW) doesn’t believe in progesterone in the treatment of transsexual women. Why? because in her experience, progesterone tends to cause masculinization effects on some women, and hence their estrogen regimen has to be increased to potentially dangerous levels (especially if the patient is over forty years of age)

Progesterone is neuroprotective, and acts as a neurosteriod, reducing oversignaling in the brain and producing a feeling of calm in some women, and helping the nerves to regrow when they are injured. It also reduces the side effects of estrogen therapy such as bloating, mood swings, swelling in the legs, and nausea. Progesterone has been shown to reduce the risk for breast cancer. (i was a very calm person, could not worry about anything. since crash the exact opposite, extreme anxiety read that lots of guys got this)

in woman they already have discovered the great importance of progesterone long ago, probably because of pregnancy, menstrual cycle and so forth what makes it fluctuate a lot. in men progesterone is very steady but declines together with testosterone as men age, so makes it effects much harder to detect and easy to describe the pros to testosterone. men and woman are not alien to each other, we are not totally different robots. in woman it is very important, so why would it not be in men? science is now becoming aware of the importance of progesterone also in men.

according to this video finasteride(dont know if it is based on research) can cause demyelination (journal.frontiersin.org/Journal/ … 00010/full also about a nasal spray that could be interesting

topic ms progesterone thisisms.com/forum/general-d … 15101.html

ncbi.nlm.nih.gov/pubmed/15669543

again im not saying this is the cure, but i think everybody that used it got an reaction to it. that must say something and the research tells us we are lacking it in our brains. so why could this not be important, in my opinion its quite logical. this thread has 47 pages even though progesterone has a stigma of being something feminizing. i think that already says something. would be great if some smart guys looked into it, maybe it could explain some of our symptoms

#937

agree with that, high estrogen low testosterone stays a problem, indeed maybe first tackle the estrogen problem. but those are great improvements you had, could be a combination of the two what made you feel better, quite hard to tell.

#938

I had a thought, but I think someone might already be trying if I remember correctly. Does anyone think that DHT cream along with progesterone would be counter productive?

#939

I’m not sure but I think as long as it’s safe then it’s worth a try.

#940

internet is full of it, women experience the same thing and it’s very normal. think this is why some people feel worse when they just started progesterone. also when the receptor is not as sensitive as it should be then of course you will get higher levels of estrogen.

#941

Good info, good things come to those who are patient with this therapy

#942

i’ve tried progesterone several times in the past, but maybe I wasn’t ready for it yet or didn’t have sufficient T levels because I literally felt nothing either bad or good. i’m considering going back on this protocol, but the thread is so long now I don’t even know where to begin looking for an updated version of it.

  • how many people have had success using this protocol/was it long lasting?
  • did it get rid of mental side effects? I could give a shit about the sexual ones at this point, I need my brain back big time.
  • what is the actual protocol/essential elements? I’ve read in another thread now about upping the dosage for better effect. will I need an anti-estrogen (clomid) as well? i’m already cycling maca, tongkat and tribulus weekly as well as eating well, lots of exercise etc.

cheers guys.

#943

Msab1990 It worked on me I wrote in this page just check the result. was fantastic but it faded I can think for two reasons. Many alcohol and drugs or progesterone alone.

I would like to know if tribulus alone can reverse gynecomastia or if it was the combination with progesterone. I think tribulus alone can do it because some recoveries here people said this.

#944

after five years, i cant control my erections in public when i see a girl that wants to play, i am emotionally flat, and after military service i realise that i have plenty of horny feeling if i compare to others, so i can say i am recovered.

i have used nothing only t4. but i am so flat. no smile no sad. i am not depressed. nothing could changed my emotions. its interesting

#945

it might be worth it for you to keep your current routine and try a higher dose of progesterone, like 15 mg. I’m doing well on it right now and have the same routine