Yes, seems they all have very different ideas about the cause. Shippen and Jacobs have both mentioned androgen insesitivity but only Jacobs has proposed a mechanism.
Wish they would all get together on thisā¦ weāre dying hereā¦
If you cannot find a laboratory in Europe please consider getting a 24 hour urinary steriod profile. Taking the 5beta to 5alpha reduced metabolite ratios from urine analysis is more accurate than serum adiol-G anyway, and can provide some further indication of the state of testosterone breakdown pathways. If you go this route let me know as I can help you calculate the ratios.
Not sure if below link was posted before. One of the conclusions is mentioned below:
āThere was, however, a strong correlation between serum 3 alpha-Adiol-G and bio T (P = 0.0005), suggesting that in men serum 3 alpha-Adiol-G levels may be dependent upon available free and albumin-bound Tā
So increasing free T and albumin-bound T would be a solution? Not sure what the latter actually isā¦
I had forgotten this topic, I donāt even know why we go on searching elsewhereā¦
If our tests donāt always present the same patterns, they are clearly the same here.
Adiol-G is LOW for everyone if us.
So there is very very little 5ARII activity.
I donāt think there could possibly be another cause to our problems, letās not forget itās that little enzyme Fin inhibited, and even if every other thing was screwed up by a cascade of events afterwhile, this little enzyme is still not returning to normal functionning, we have the proof here. We could go on forever trying a zillion other things, this little enzyme would stay forever asleep anyway if no med is targeting it directly. (If only we could swallow something stimulating 5ARII activity but that is impossible for now )
Do we have examples of post-fin sufferers who showed good level of 5ARII activity?
With the way my blood testosterone levels are I should be horny as hell.
My serum test is over 800 consistantly.
My free test was 188 (top end of the range)
My DHT is normal but fluxes between 35-60 (25-75)
3-Adiol-G is 256 (260-1500)*
Cortisol is 72.2 (5-55)
Pretty much everything else is normal. (LH, FSH, SHBG, prolactin, estrodial)
My thyroid shows low T3 but I need more tests there.
*It seems my body isnāt metabolising Testosterone/DHT correctly. That seems to be the issue, whether its thyroid related, I have no idea. It seems that testosterone/dht metabolism is the root issue, which is why many of us like myself with normal or high Test, are still not better. The question now becomes, what altered testosterone metabolism? How did fina change testosterone metabolism permanantly. Why are the enzymes not working? Am I low on the necessary enzymes? Can I increase them? I am getting more tempted to try the cyclosporin a idea everyday, but I want to exhaust other methods first.
I think I maybe an excellent test rat for any proposed treatments because I donāt seem to be having the low test or screwed up estrogen issues that many of us have, yet I am suffering most of the same side effects as everyone else. In fact somewhat worse than others.