Ozeph Regimen and Supplement

Therapeutic Efforts Supplements & Lifestyle
#105

Thorough article on the mechanism behind pfs and a call for its recognition:

https://www.sciencedirect.com/science/article/pii/S0015028219325993

It goes along many things we’ve discussed on this forum, while dismissing others. The bad news is it states that "The pharmacokinetics of finasteride and dutasteride are as such that they are nearly irreversible inhibitor of 5α-Rs, with slow rate of dissociation, leading to a long-lasting effect of the drug, regardless of dose administered. " which "may lead to epigenetic changes, such as DNA methylation of the androgen receptor gene or the 5α-reductases genes. "

It’s a long read, with all the citations, and goes in the direction of what this site is trying to accomplish: recognition of PFS.

Provides no cure though but it does accurately describe the types of epigenetic changes that occurs. Personally, I will stick with what I consider to do “epigenetic repair” as suggested here:
(Beware of the food suggestions. Resveratrol, curcumin, catechins and quercetin Have all made me feel bad and are on the restricted list on this site, I believe)

and here:

I’m taking Nicotinamide Mononucleotide as a NAD+ booster and got good results from it.

If I ever get a few extra millions, I will go see Dr. David Sinclair, show him all the evidence and I’m sure he would have at least some leads as to what to do. He erased all epigenetic markers on mice (but I don’t know how the mice did after !)

3 Likes
#106

Ozeph, what if i’m already too skinny and having muscle wastage from symptoms.
i feel i cant do keto. and also my family doest contribute. i just cant do keto. what should i do?
should i take BHB salts? would it work even if i keep eating carbs?

#107

I recommend reading about Sinclair’s recommendations, maybe even his book, if you have determined you can’t do what Ozeph is doing.

#108

BHB salts could help on the days your doing the tricks below. Butyric acid supplements would help your guts and guts biome.

There’s a way to be keto/carnivore and gain weight with targeted carbs intake but it seems impossible for you due to circumstances

@vkg1 is right. Dr. David Sinclair recommendations could help. I tried them all, and also the meds/supplements he’s suggesting and I can tell you Resveratrol is not good for pfs. Metformin was bad in my case because I’m keto, I don’t know if it would do you good. Same with Trans-Pterostilbene. However, the NAD+ boosters and Nicotinamide Mononuclotide (NMN) were really helpful.

Other natural tricks are hot saunas, cold shower (or both in succession), and running out of breath exercise. Whatever the exercise, running out of breath is what triggers the benefits.

There’s exercise while carbs being depleted if you can manage to deplete your carbs through fasting.
To gain weight, you can eat a mixture of carbs and fat. Donuts come to mind but there’s healthier alternatives. I make oatmeal with ghee (clarified butter) and I did increase my body fat from below 12% to 12-14%. I didn’t eat much of it.

For muscle gain, it’s protein, creatine and weight lifting. But pfs must be under control to attemp that.

#109

After 2 years, I’ve lowered most supplement and became more strict on the diet.

Here is my complete regimen:

Upon waking up:
5-HTP 50mg
Tyrosine 500mg
L-Dopa 350mg
Half pill of most Vitamin B (1,3,6,12, biotin)
Nicotinamide MonoNucleotide (NMN), a NAD+ precursor.
Sex herb of the week, which I cycle: Pine Pollen, Trubulus Terrestris, Horny Goat Weed
Careful, some have had adverse reactions to these. Try little and wait before increasing to normal dose. If you have bad reactions, stop.

Breakfast:
Coffee with coconut milk, no sugar. I use 0 carbs sweetener, it may not be good for all.
3 tbsp Ghee, pinch of salt
Blend in a jar with an electric whip.

Right After Coffee:
Half Multi-vitamins for men
500iu or 1000 iu of vitamin D3
25mg of zinc (half a pill)
One day I take Boron 3 mcg
The other day I take Vitamin A 5000iu
Careful, some have had adverse reactions to vitamin A.

I do at least some exercise every day. Exercise is mostly resistance training but also some cardio.

3pm on empty stomach:
Vitamin B3 Niacinamide
Sex Herb of the week.

Pre dinner at 4pm
Often, I will eat two time within a 1-2 hours window.
The first meal is meat with 1 duck egg and ghee (some low sodium salt)

Dinner around 5pm, sometime only meal of the day:
Fat ground beef 150 gr (or some other fat cut of steak), 4 tbsp of ghee, 1 free range duck egg, 50gr of steamed spinach and the equivalent of 1 tbsp of dry lentils, cooked into a puree (I make large batches AND FREEZE), lemon juice and low sodium salt (60% potasium, 40% sodium)
Fat can also be partly lard or tallow.
I first melt the ghee with the lentil puree with lemon juice and low sodium salt. I whip to a cream and add beef and spinach.
I eat with 100 gr of unpeeled cucumber, 12 olives and often 1 can (50gr) of mackerel (tomato sauce drained). I always sleep better when I ate mackerel.
1 glass containing 150ml of the magnesium mix below, and sparkling water.

After 6pm
I don’t drink any liquids so I don’t have to wake up and pee at night. That really messes up my night and the next day.
I only drink the morning coffee, the magnesium mix and water. Nothing else.

I need 3-4 hours to digest the food before taking sleeping meds or herbs or they will mix with the food and mess up my night

10pm:
3.5 mg Clonazepam (sleeping pill)
20 mg Hydroxyzine (anti-histamine)
10 mg Melatonin (also fixes epigenetic damage by itself)
1000 mg Valerian extract
500mg Lemon Balm extract
500mg Passion flower extract
500mg Hops extract

That won’t even make me yawn or sleepy until I take:

Before sleep and at least 30 minutes after taking the previous pills:
2 tbsp Oatmeal (Rolled Oat), 2 tbsp of water, 1 tbsp of ghee, 1 tsp of Inusitol (vit B8)
Facultative: 0 carbs sweetener and/or vanilla, pinch of salt
Mix than add ghee, Microwave 30-45 seconds and mix again

This raises insulin and lowers cortisol. The insulin and drop of cortisol usually knocks me out and I barely have time to do my evening meditation before falling asleep.

I keep 700mg of Inusitol in a pill, and 250mg of Chamomile extract, 250mg of hops extracts in another pill next to my bed. When I almost inevitably wake up after sleeping 5 hours, I take those 2 pills and go back to sleep. I’ll finish the night dreaming and waking up a few times. This is not the dreaming zombie state of tossing around and barely dreaming surface dreams close to reality. What I get is derived from that but it has gotten much better over the years. It’s actually quite pleasant to have all those dreams every days.

Also note that despite taking lots of sleep meds and supplements, I didn’t build up tolerance and sleep quality is improving with time. I intent to reduce those meds and herbs when sleep is good enough

Magnesium mix :
In a 1.5 liter bottle: Magnesium Chloride 10 gr, Potassium Chloride 5 gr, Creatine 5 gr, 150 ml apple cider vinegar, fill with water to the rim. I take no more than 150ml a day, before 6pm so I have time to urinate the extra magnesium. mix with soda water to fill the glass. It’s delicious.

Conclusion
As you can see, I am not cured. But all neurological (no more anxiety), physical and sexual symptoms are gone except for slightly lower sex drive but still above others of my age (I’m 53) and insomnia which is kept under control and stable with the meds and herbs.
I have a good quality of life and could live the rest of my life like this. However, I see slow improvement in sleep so I believe within 2-3 years I will be better yet.
Is there a cure ? I don’t know. But I found a way to make my life normal and be alert and productive during the day and sleep at night.

1 Like
#110

So whats your exprience?

#111

I was crashy… I don’t really “crash” anymore. But sleep got worst until days became foggy and unproductive. I stopped, went back to my baseline diet and everything got back to normal. Resveratrol is not for me.

#112

Here is a video which focuses on sleep, might be helpful for you, to listen through:

Its really good and maybe one of the best insights on that topic.

#113

@hopeless94

Thank you. I’ll watch it when I have 2 hours. Do they talk about PFS ?

#114

Sorry to hear that the insomnia is still with you. How’s the Nicotinamide Mononucleotide been treating you? Any downsides to taking it?

#115

It removed my burning lips (which is a reduced symptom of other people’s dry skin) and my burning eyes.
After and before I crashed those were real issues, Lately they only happened during/after showers from contact with soap, but now it’s gone.

I tolerate it well, no side effects from it, and aside from the above benefits I read it helps repairs the epigenome. It had positive effects on the last few symptoms I had beside insomnia so I guess it helps.

Thanks ! I don’t suffer from it. I just needs to take meds and herbs and I sleep well (above average deep sleep and lots of dreams. I have a sleep monitor). I wake up well rested and have productive days.

Aside from having to take those pills, my life is normal and I have no symptoms.

How are you doing with this disease ? Any improvements ?

1 Like
#116

No, its more general but imo the best source for sleep problems

#117

What brand of nmn are you using?

#118

NMN Max, because it was cheap… It’s usualy expensicve.

https://www.amazon.com/gp/product/B08CY2VFST/ref=ppx_yo_dt_b_asin_title_o00_s00?ie=UTF8&psc=1

@hopeless94
I do find it interesting when she says repairs take place during deep sleep. This is why I chose to take a bad med: clonazepam, over not sleeping. I figure not sleeping would be more damaging than the med.
I get above average deep sleep every night. Normal dream sleep and overall enough sleep.

#119

Hey Ozeph- I’m a little confused. Later down you say that you’re still on a lot of supplements that keep you running- are you advocating for supplement usage or the diet/exercise approach?
I’ve been stuck with pfs for over a year now and have seen no improvements

#120

The diet and exercise seem to make almost everybody better. Lots of recovery stories have those elements.

Supplements are more case specific. Most of what I take are minerals and vitamins, except for sleeping meds and herbs. That’s because insomnia is my last severe symptom (and the only one I’m aware of).
Someone with sexual symptoms and no insomnia would have no use for those.

I don’t think supplements can cure people. But it can be a complement to diet and exercise.

That’s only my opinion. Recovery stories are not that common (I’m sure more recover and just don’t come to the site anymore). There was that guy that recovered with Rhodiola Rosea 500mg in the morning and Acetyl L-Carnitine (ALCAR) 500mg both in the morning and afternoon.

Diet and exercise seem to make most people better.

3 Likes
#121

So as far as diet you’d recommend the carnivore diet is what I’m picking up from your comments right?

#122

Yes, but a ketogenic carnivore diet that is 70% calories from fat, 26% from protein and only 4% from carbs.
Obviously, to achieve that, you need some plants as meat has no carbs.
An epigenetic specialist in Russia suggested eating only meat (fat meat) and that certainly yield result or he wouldn’t advise that.
On my part, I changed most ghee for palm oil as it is 56% MCT oil and gets me into ketosis very fast. I take 2 tbsp of oat before sleep to provide some of those calories from carbs.

So to conclude, either diet has zero to very very low carbs, one has more meat (and only meat) and the other can have some specific plant products chosen for specific roles. Both diets would put you in mild to medium ketosis (carnivore diet for the former, ketogenic for the latter). Being in ketosis makes your body more likely to fix epigenetic damage, especially if doing those Tricks to repair the Epigenome

I’ll have to add that I’ve been doing steps to cure a candida infection many of us have (pfs seems to deplete guts biome, which makes fungus fill up the vacuum). Candida feeds on carbs so the diet would have reduced them to a certain degree, but our body produces carbs out of proteins so glucose blood levels are (always) stable. I took probiotics everyday along with potato starch, which is a resistant starch our body cannot digest but is food for bacteria. Green banana resistant starch can also be taken. I also took Candex, which are enzymes that dissolves the candida biofilm and leaves it unprotected so it can be attacked by our immune system or the newly introduced guts bacteria.
My sleep got better and I had to reduce sleeping meds as it made me too drowsy in the morning.
I also took a controversial approach I will not discuss here as it is too controversial. I’ll post on it later with all appropriate warnings if I get decidedly noticeable results. So far, I had to reduce sleeping meds again but I cannot link it to this new approach with any certitude.

I really suggest people try probiotics along with prebiotics (bacteria food like resistant starch, fibers etc…)
If it makes you feel bad, stop, if it improves your condition then go on !

Good luck !

2 Likes
#123

Thanks for the detailed reply! I’ve tried 2-3 different brands of probiotics with differing numbers of CFUs…I guess I’ll try it again along with the more intense diet changes you’ve mentioned…

1 Like
#124

3 years 5 months after crashing, 3 years 3 months in the diet.
I’ve lowered supplements and follow the diet.

Here is my complete regimen:

Upon waking up:
5-HTP 100mg
Tyrosine 500mg
L-Dopa 350mg
Half pill of most Vitamin B (1,3,6,12, biotin)
Nicotinamide MonoNucleotide (NMN), a NAD+ precursor.

Breakfast:
Coffee with coconut milk, no sugar. I use 0 carbs sweetener, it may not be good for all.
1 tbsp Ghee, 4 tbsp+ palm oil
Blend in a jar with an electric whip.

Right After Coffee:
Half Multi-vitamins for men
500iu iu of vitamin D3
25mg of zinc (half a pill)

I do at least some exercise every day. Exercise is mostly resistance training but also some cardio.

I’m experimenting with N-Acetyl Cystein (NAK) and Acetyl L-Carnitine (ALCAR). I’ve been taking doses arounf 500mg each and it’s too much. I’ll have to cut down by half and take every other day. NAC has improved my sleep but only if taken in small dose in the after noon. ALCAR gives me more energy in the day time. Both can interfere with my sleep if not careful.
I’m also taking sex herbs (Tribulus Terrestris, Horny Goat Weed, Tonga Ali) once in a while to push androgen higher an trigger my body. So far so good, body odors are back without herbs.

Dinner around 5pm, sometime only meal of the day:

My version of Bearnaise sauce:
2 tbsp of crushed. cooked lentils, thickness of a thick sauce
3 tsp lemon juice
1/4 tsp low sodium salt
2 Tbsp of ghee
1/3 cup of palm oil
I wave the whole thing 1 minute to melt the ghee
Whip in an egg and the oil, water and lentils all mix together.

This sauce is my main source of calories, along with the fat in the morning coffee. It’s the main thing in my diet.

I now add to the sauce for taste and nutriments:
6 black olives
6 green olives
3 tbsp of diced canned tomatoes
some yellow mustard for taste
some fish sauce (I’m in Thailand, you can skip)
80 gr. of cooked spinach, chopped up
1 pickle size cucumber (or 1/4 regular cucumber)

For added proteins:
Fat ground beef 150 gr pree-cooked

I always sleep better when I eat mackerel so I often take a small can of mackerel, with salt, lemon juice and Thai herbs

10 oz glass containing 150ml of the magnesium mix below, and sparkling water to fill the glass.

After 6pm
I don’t drink any liquids so I don’t have to wake up and pee at night. That really messes up my night and the next day.
I only drink the morning coffee, the magnesium mix and water. Nothing else.

I need 3-4 hours to digest the food before taking sleeping meds or herbs or they will mix with the food and mess up my night

10pm:
3.5 mg Clonazepam (sleeping pill)
22.5 mg Hydroxyzine (anti-histamine)
10 mg Melatonin (also fixes epigenetic damage by itself)
1000 mg Valerian extract
500mg Lemon Balm extract
500mg Passion flower extract
500mg Hops extract

That won’t even make me yawn or sleepy until I take:

Before sleep and at least 30 minutes after taking the previous pills:
1 heaping tbsp of slow cooking Oatmeal (Rolled Oat), cover with water
1 tbsp of ghee
1 tsp of Inusitol (vit B8)
Microwave 30-45 seconds and mix

(I brush my teeth after eating the oatmeal) This raises insulin and lowers cortisol. The insulin and drop of cortisol usually knocks me out and I barely have time to do my evening meditation before falling asleep.
This little carbs before sleep does a lot to eliminate carbs cravings. However, if I find myself dreaming about carbs, I may take 2 tbsp oatmeal on the next evening only.

I keep 700mg of Inusitol in a pill next to my bed. When I almost inevitably wake up after sleeping 5 hours, If I’m really alert I’ll sometime take that pill and go back to sleep. If I’m drowzy, I can do without.
I’ll finish the night dreaming and waking up a few times. This is not the dreaming zombie state of tossing around and barely dreaming surface dreams close to reality. What I get is derived from that but it has gotten much better over the years. It’s actually quite pleasant to have all those dreams every days.
I’m fully rested and functioning for the day.

Also note that despite taking lots of sleep meds and supplements, I didn’t build up tolerance and sleep quality is improving with time. I intent to reduce those meds and herbs when sleep is good enough

Magnesium mix :
In a 1.5 liter bottle: Magnesium Chloride 10 gr, Potassium Chloride 5 gr, Creatine 5 gr, 150 ml apple cider vinegar, fill with water to the rim. I take no more than 150ml a day, before 6pm so I have time to urinate the extra magnesium. mix with soda water to fill the glass. It’s delicious.

Conclusion
As you can see, I am not cured. But all neurological (no more anxiety), physical and sexual symptoms are gone except for slightly lower sex drive but still above others of my age (I’m 54) and insomnia which is kept under control and stable with the meds and herbs.
I have a good quality of life and could live the rest of my life like this. However, I see slow improvement in sleep so I believe within 2-3 years I will be better yet.
Is there a cure ? I don’t know. But I found a way to make my life normal and be alert and productive during the day and sleep at night.

3 Likes