Mifepristone worked

Therapeutic Efforts
#122

Yes,
The guy on the other forum said the following. I copy and pasted it.

Hi Ronnie,

It definitely made a difference in my mood, energy levels and stress levels so far. Sex drive is still recovering, slightly improving on some days. It’s been almost 4 weeks since stopping and my overall mood is much better than before. I have to say the Alibaba product is legitimate, I just feel the drug’s effects were more pronounced the first time I took it.

I went to get blood work done last Thursday to see where my hormones are at, I should be getting the results sometime this week. I’m going to give it another week or two and might try for another 1 week run of mifepristone to see if my sex drive fully comes back after that.

Thanks for checking in.

Regards (removed name)

#123

Hey @Ronnie99 thanks for update,

This guy took mifepristone for the first time? It seems like he used it in the past with some results?

Best regards

#124

My experience was similar in the regard that the first time I took mifepristone I felt like the effect from the drug while on it was much more pronounced then future trials . I suspect that the reasoning why it worked for me the first time when coming off of it was because of the pronounced effect that it had on me the first time I was on it

#125

Yes, I think in a few months he should try it again and see if he further improves.
Its like the HPA Axis negative feedback keeps getting blunted and stressed for some reason, the Mifepristone gives it a reset and then over some months some mechanism keeps stressing the body and again blunts the negative feedback loop with cortisol (glucorticoids).
Whats your thoughts ?

#126

Are you going to give it another shot again with a higher dose and good source ?

#127

I’m not sure it’s a tough call. I still have RU left from my second batch and i have no fool proof way to truly know the quality unless I pay big money to have it independently tested

Also thinking back the first time I had approximately 600 MG from the same source. And the first 150 MG from the 600 MG was what gave me that temporary 5 week 80 percent sexual side recovery. When the temporary recovery faded I ran a second, third and fourth cycle from the same source with out being able to replicate my experience from the first trial. So this leads me believe it was not an issue of quality. From the second source I have ran so many trials I lost count. Probable about 10 trials and was never able to come even close to replicating.

For the record I did not get before or during labs while on any of my trials but going off of feel I don’t think I was shutting my self down. One guy who had labs ran while on it had his progesterone shoot through the roof which is more or less the opposite of getting shut down. It’s blocking the progesterone receptors mainly and partially blocking the androgen and cortisol (GR) receptors.

#128

The guy from Canada sadly reported no changes. It didn’t work. He bought mifep from China, god knows if it was legit or not. But i don’t know.

#129

i think why the experience the first time works, is because our minds let these substances into the brain, and once the brain doesn’t feel safe. it’s starts panicking. i think this is what happened with accutane or finasteride. the brain started seeing this as a threat and began to try to protect us from the drug. this makes a lot of sense to me from experience. i smoked weed, got really high. ended up having a panic attack. after this experience, i’ve never been able to get high from weed. i know there are people on here who don’t react to drugs or alcohol. the solution for the people who see improvements from these drugs, is finding out how to make the brain allow these substances back into the brain. there is this company that has developed a technique that allows substances to bypass the blood brain barrier. if we could incorporate this technique into our lives with mifepresitone, or any substance that people see recovery with, magic mushrooms. i think this is the mental block that is not allowing a lot of us to recover properly. if we can bypass this we can get relief

#130

Good point mate, and the blockage you are talking about is shown in the study with a diagram of how Mifepristone provides the unblock your referring to. Below is the diagram im referring to based on the Mifepristone number study. Good observation you made.

On the image below see how the RAR (retinoic acid) is blocking the GR (glucorticoid receptors) and Mifepristone has come in and unbloced the GR from RAR, allowing GR to now do it proper job. Very important study the full link of the study is below.

image
image1242×2688 393 KB

1 Like
#131

wow! very interesting. i think that many people suffering could see recovery with these combined steps. hopefully this technology can be used with all sorts of drugs to bypass the blood brain barrier. this technology is already in clinical studies so hopefully in the near future it could become accessible to people like us and we could essentially be cured

#132
1 Like
#133

This is very interesting indeed, but wouldn’t a cortisol blood test show if you’d have this problem?

All the RA treated rats had elevated corticosterone due to impaired negative feedback on CRH secretion.

And since cortisol, not corticosterone is the main glucocorticoids in humans I’d guess you’d want to look at that instead.

1 Like
#134

Good point, I have and my cortisol is very high throughout blood and saliva collecting every 4 hours.

I tried Mifepristone and I’m 85-90% pre pas pfs.
and I only took it for 7 days and that’s it.

The big difference between mifepristone and supplementing is supplements work while your taking them just bumping up your levels, where as Mifepristone unblocks or resets something, and only take it for 7 days.

I feel my old personality is back, This treatment is not to be undervalued that’s why I’m passionate about other people giving it a try, otherwise there is no real motivation for me to be here other than to show my experience and benefit from it. I always said that if I get better I will stick around for a while
And tell people of my experience and how I feel this can help many others.

5 Likes
#135

Yeah I’m not saying it’s a bad treatment or anything. Now we are not rats, so it’s not always true it would work the same way in humans. But there’s a possibility since it works on the GR in humans to.

I just wanted to point out that it’s probably best to get cortisol tested first and if it’s indeed high it might be a great potential treatment.

Because as you said, it can indeed “reset” gene/protein expression and thus reinstate the negative feedback mechanism that GR activation should have on CRH secretion.

1 Like
#136

Yes good point, but its being used on other studies like depression on human, alchohol wothdrawal with great results.

Yes mine was high…so based on that study i got back to 85-90%, i thank god everyday….as i didnt know how hole deep i was in until this worked.

Yes exactly one main goal is to secrete CRH via the GR negative feedback loop.

Have you tested your cortisol, blood, saliva, cortisol awakening test ?

1 Like
#137

Yeah I did. A couple of months ago it was slightly out of range.

Last test it was in range but in the higher range. This was both blood morning tests.

I’m thinking about getting a 24h test next.

#138

@Ronnie99 thanks good find.

It seems to be quite the opposite of FIN action described on HPA axis in study below.

1 Like
#139

Lowered dopaminergic activity and impaired stress coping is what they found.

The Baylor study discussed some of the same things in their recent study.

There’s much more to it but I can’t cite it all. It’s a great read and much of it mirrors my own experience.

#140

So mifepristone worked for you ?

How long did you take it ?
What dosage ?
Did you feel better on it or after coming off of it ?
Where did you source it from?

I have been on vacation and out of the loop for a while

I had a temporary near recovery from mifepristone back in 2017 at 50 MG’s for three days. My temporary recovery came after I came off the mifepristone in the form of a “snap back” haha I know bro science. But it was very real and faded over a 5 week period. I tried mifepristone again several times since this time but a majority of those times I tried the mifepristone again sourced from a lab from China . It came in a big bag in powder form and was sketchy to say the least

The first time in 2017 when I took the 50 MG’s for three days straight I sourced three 50 MG tablets from a European website and they arrived in pill form. That specific European source became shady and screwed be the second time I ordered from them by only sending me a quarter of my order and possibly fake mifepristone

My point is that maybe it’s all about quality of the mifepristone that we trial. Also mifepristone if I remember correctly without doing more research is only temporary partially blocking the Cortisol and AR receptors while it’s temporarily blocking the Progesterone receptors to higher degree, which makes sense because mifepristone causes abortions in women by blocking the progesterone receptors

And your PAS syndrome …. Interesting

When did you take the mifepristone? Maybe I will try again . But I need a good source

#141

At 50mg mifepristone would almost only antagonize the PR (progesterone receptor).

You need about 5mg/kg to antagonize the GR (glucocorticoid receptor). So about 400mg for a 80kg male.

I’ll make a post discussing the science in a few days.

2 Likes