Upon reflection it looks like pregnenolone isn’t working for me. I have varied the dosages and spoken to Chilln in in-depth detail about things.
The reason for this, appears to be a rather complicated one but here goes:
The pregnenolone is converting, primarily down the testosterone hormonal chain (pushing up my estrogen!) instead of the cortisol hormonal chain as mainly intended. This is the exception rather than the norm and attributes to highly upregulated 17α hydroxylase enzymes. This would explain my constantly high T/E/DHT and my early hairloss. I anticipate that my progesterone levels read as low but i STILL await confirmation of this.
See below:
By my interpretation, i’ve got a natural imbalance that fin has massively accentuated, in that not enough of my pregnenolone “the grand-mother of all hormones” converts down the progesterone path but instead down the DHEA pathway predominantly. You’ll notice other interesting derivatives there such a allopregnenolone… This all explains why my aldosterone is through the floor.
This means i need to supplement progesterone instead of preg. This becomes difficult; preg is safer than prog and easier to guage dosage. Prog, not so much. That said, when there’s a will there’s a way.
I’ve now did many hours of research on progesterone and it’s massively interesting. I’ve read that there is an absolutely critical balance between four key hormones:
T/DHT/E2/Progesterone. If i am high all the first three (all out of range high!!) but very low in prog (awaiting confirmation), then there’s huge imbalance pressuring my entire body.
Optimum progesterone levels will maintain healthy balance with E2 and DHT. It lowers both and should help libido markedly.
Here is an interesting thread on Dr Crisler’s forum about progesterone:
musclechatroom.com/forum/showthread.php?15476-Safe-uses-of-Progesterone
Read if you’re interested. There are many good studies in it showing just how useful progesterone supplementation can be.
Just so people don’t think i’ve lost the plot. Dr Thierry Hertoghe, one of the top guys, who recognises PFS but takes fin himself, found he had soaring e2 levels courtesy of fin. To control this he takes (took?) 100mg oral micronized progesterone ED which works a charm. This is far from a blind alley.
Anyway, i won’t be acting on this atleast until i attain confirmation of my prog levels. I could be in for a surprise.
On a side note, for now, given my ridiculous e2 levels, i’ve felt the need to experiment with an interim measure which i feel is a good idea. I feared developing gyno or something. Small amounts of proviron (as opposed to going back on arimidex) daily…half a tablet (12.5mg). I’ve been doing this for 4 or 5 days now and have noticed subtle but definate improvement in all areas (semen more watery though but white…strange). I’m going to do this for 30 days and see where it takes me. Watching other people’s experiences with proviron it seems their positive effects were short lived, so i’ve tried a smaller dose to hopefully aid some sort of more sustainable improvement. We’ll see how that goes.
Lastly, i gave up the spinach diet. Had to be done. Almost 3 weeks of it without any improvements. Worth a try, though!