Yep…
Keep dreaming it is a “t/e” ratio problem.
Oh, i knew there was undertones here somewhere.
Regardless, if sex hormones are the whole part of the puzzle or not, its imparative to get these hormones normalised. Symtompatic relief (atleast partial) will usually follow.
Double estrogen levels will negatively affect anyone, PFS or not. So it’s important to take action to fix these levels and take pressure off your pituitary. My FSH should find relief as should my prostrate (estrogen is a player in prostrate cancer it is now being suggested) and my body generally.
So, i fail to see the problem. If you have a bad hormonal profile i suggest you fixing it too.
As promised im not going to detail my progress for reasons i started earlier in this thread.
Just one thing: Last night i took zinc, trib and a few other supplements before bed and honestly, it was the worst night i’ve had (of nocturnals etc) since i began treatment.
No more regular supplements apart from vitamin E and lysine. I’ve dropped the other supplements before too and have never noticed any changes.
L-arginine is okay, too, though, but it doesn’t do that much to warrant consistent dosing. I don’t take HGW much but it’s there if i need it for a marginal performance boost although i find a 20mg of cialis to give me a boost for a few days where i need it.
UPDATE:
Ok so i figure i owe you guys an update.
This week (week 3) has been really, really, disappointing. Why? Because I was having (slow) steady progress with literally every symptom up until this point. Then it all just dropped off. I’m almost back to base right now.
Penis size back to needle. Insanity isn’t the word. It went from full (flaccid and erect) to half full in the space between Week 2 and Week 3. Exact same thing happened with the PREG cream. There’s clearly something in my body making my penis not its normal size.
I’ll detail thing out later week by week.
I neglected to get bloods for the first two weeks because things were kinda going swimmingly. Niave of me. I have bloods from Thursday past there (mid of week 3) and i should have the bloods back this week. Either my estrogen has been pushed too low or i’m simply not addressing the root issue. OR week 2 was the week i did loads of exercise. No idea if this is relevant or not. I’ll do loads this week to see.
We’ll see. I’ll probably adjust dosages after i see my estrogen level from Thurday. I might as well do a little trial and error and see if i can find novel optimum levels. If things aren’t great after 6 or 8 weeks i might incorporate clomid or PREG and utilise the ongoing blood tests to monitor how i react to those.
One thing at a time though. Will update with my latest bloods in the next day or two. Still in good spirits despite this set back. Surely things can be fixed if ive experienced partial recoveries twice now…
Ok got my estrogen levels back
Baseline: 199 pmol/L (<156)
Week three: 196 pmol/L (<156)
WOW. No wonder i reverted back to base symptoms on week three. I’m kicking myself i didn’t get Week 2 bloods when i felt good.
Will adjust dosage and see how it goes. I started out extremely low on the dosages.
I guess this isn’t terrible news. Plenty of scope to work with yet.
Hi,
My estrogen levels seem to be soaring. Going beyond the " range " for the first time. Here is my latest blood work:
Free Testostrone: 11.43 pg/mL , 3.84 - 34.16
Total Testostrone: 505.50 ng/dL 241 -827
Serum Cortisol : 15.10 microgram/dL 4.30 -22.40
Estradiol : 60.56 pg/mL 10 - 50
Androstenedione 1.54 ng/mL .70 - 3.50
SHBG 47.90 nmol/l 13.00 - 48
Prolactin 6.35 ng/mL 2.10 - 12.99
DHT (5 ALPHA) 751.57 pg/mL 250-990
Vitamin D 39 nmol/L insuffiecient good range: 75 - 250
TSH 3.48 microIU/mL .35 - 5.50
FSH 5.38 mIU/mL 1.40 - 18.10
LH 7.42mIU/mL 1.50 – 9.30
How are u feeling? Are your erections improving? I am considering a low dose arimidex but my doctor is hesitant. Will Zinc alone help? My Prolactin has gone down though. It used to be around 13 ng/ml
I have no clue why the aromatase is so active? My big 2 side effects are bloating and ED.
KIR
your liver is not eradicating estradiol properly. fin affects liver, i am absolutely certain of this, my issues went way when liver was addressed.
taking arimidex is a band aid.
improve liver and estradiol metabolism improves.
i believe fin affects liver functioning in terms of hormonal balancing. liver is responsible for hormonal balance, testosterone, adrenals and thyroid. shbg is made in liver to counter high test, preg is made in liver, thyroid binding globulin is made in liver. you get the picture?
estradiol domniance should not be treated by popping armidex as that just causes more sluggisness of liver.
thats why some people recover in time as liver slowly heal. fin also affects adrenals due to its affect on liver and thyroid. remember preg is made in liver as is thyroid hormones.
treat the liver and you treat other issues. the answer to liver healing is not within the realm of westerm medical science you have to look elsewhere.
Thanks for your opinion.
It’s insane how many conflicting stories we get. One doctor calls the other doctor’s protocols “bonkers” for instance. What chance do we have?
I’ve had enough. I’m doing one thing at a time. I’m giving the arimidex a fair shot and make the necessary tweaks, give my body the right amount of time and consistency to give it a chance to normalise (if it wants to) and monitor bloods (and how i feel each day) bi-weekly.
IF i can get my T/E ratio corrected and sustained and i still don’t feel good…or if i can’t sustain my new ratio after i systematically try taper off the arimidex in the future then i’ll look further into things. EG: Preg and after that, those herbs.
In short: I’m not going to be do what I preach against: one who jumps off and on different treatments making snap conclusions of what does and doesn’t work. Considering it took over a year for me to notice what fin did to me, I’m alive to the fact that the fix will be a progressive one.
Step by step.
Wow your estrogen is worse than mine. But my testosterone is high yours is mid. THAT is even more alarming as you T/E ratio is even worse than mine. Surprised you don’t have gyno. You definately have estrogen dominance in your body, too. Considering im using arimidex i recommend you doing the same. Make your own thread though 
Hi Mens Rea,
Yes, its estrogen dominance. No gyno because prolactin in control…I developed gyno while my prolactin levels soared. I think my t is getting converted at higher than normal rate to estradiol… My DHT levels are good. I have ordered a 3 alpha diol test and results expected in a week. My doctor is hesistant about using another endocrine disrupting drug. He has asked me to wait for a few weeks and check the levels again and then start a v low dose arimidex. I have started taking vitamin D supplements ( first ever supplement in my life). WRT work outs, he has asked me to do weights twice a week, intense cardio twice and low intensity twice. He has taken cognizance of the fact that whenever I have embarked on a heavy training regime, my symptoms have gotten worse. He has given me 4 weeks and incase my blood tests and symptoms are not favorable, he will start the arimidex. According to him even at estrogen levels high normal, sexual functioning could be normal… however, he as like other doctors, feels there is something else that has gone awry…Eventually, after four weeks if there is ni improvement, he will bring down my E2 to 30 pg/mL and if I improve substantially, bingo, else it is something else…
KIR
UPDATE:
I’ve upped my dosage this week. Literally zero benefit of doing so. Maybe one night of good erections. Semen is the only thing that has improved but even this has plateaued.
I will continue with this experiment until the end, though and will monitor my responses ot different T/E levels etc. Nothing changes apart from my mindset about my PFS. I suppose that might change though if i somehow recover during or after this treatment course though!!
I’m beginning to realise that I am potentially “that guy” with a good hormonal profile despite the symptoms. If my T/E become “normalised” and i still feel no different i’ll have high Tesosterone (very high), very high DHT and in range estrogen and STILL have these symptoms which I really shouldn’t have. Obviously there are other key hormones, but thus far all of them seem “normal” from the testing I’ve had. I’m pushing to have my 3-adiol-G, reverse T3 and other key bloods taken though, perhaps they might offer insight that I currently don’t have.
So basically…
I’m looking into potential root causes. Non-hormonal. A few of you guys will probably be about to jump over me saying “I told you so”. Cool. But atleast I plan on being productive. I’m going to get referred to a urologist and discuss my thoughts with him. I have two specific things in mind…I believe im bound to test “positive” for one of the two, but we’ll see. One of the things isn’t actually urologist related, though. I’ll update you guys on that one if i make any head way with it - don’t want to be raising false hope.
Mind well and truly opened!!
Let me know how the 3-adiol-G tests read.
Yeah, trial and error, eh 
Gotta get that 3-DIOL-G done. It seems to be the best primary marker for this problem so far… that and other 5ar2 metabolite tests.
You get the 3 adiol G test results - and then what?
Exactly. I would pushed for it harder long ago if there was even a hint of a gameplan. There isn’t. There results are the 3-adiol-G at this point in time are nothing more than informational. If i have low 3-adiol-G then I basically know I’m fucked. Awesome.
I shouldn’t joke though - I HAVE read that boosting free testosterone levels and also cortisol levels can help boost 3-adiol-G. Don’t ask me to add to that or even confirm the validity of this though.
Well is it any better not knowing?
At least by knowing this you know its not something else, and it adds evidence to support our cause.
When I go home in a week I am meeting with a researcher from a university who has studied 3adiolg and was familiar with PFS when I spoke with her about it. She apparently has a colleague currently researching it. I will try to meet with this person while I am there as well.
Well, right now it doesn’t make a pile of difference.
I’m not even convinced my 3-adiol-G will present as low. It would be strange if it is given just about every other level is high. Dr Crisler says he has a few patients with perfect 3-adiol-G and urinary ratios despite having the same symptoms. So things appear to run even deeper than these readings.
Awesome. Let us know how that goes
Update:
Things aren’t going overly great. Disappointing. I upped my dosage of arimidex for the past 2weeks (getting bloods next week to see where im at) but didn’t feel much different. If anything i felt worse after taking a larger dose. My estrogen levels, im betting, have barely burdged despite my testosterone levels being as high as TRT patients.
Serum Tesosterone 36.7nmo/l (10-30).
NB: My IGF-1 is no way out of range too. 
I shouldn’t be having the problems im having with these hormone levels, no way. That said, it’s weird that my estrogen levels aren’t budging. I’ll talk to my endo about this, I might even consider letro or aromasin.
I’m also pushing to have Reverse T3 and 3-adiol-G readings done.
On the side though im going to push other things:
- Im just back from my GP. I said i wanted to get referred to a urologist for a prostrate ultrasound and all the works. She said basically that all this hormonal stuff im doing with my endo is a bunch of crap (i disagree, obviously). She referred me to a guy who “deals with all of this stuff”, a Dr Wallace Dinsmore. wallacedinsmore.com/ He used to be a urologist and he now specialises in sexual health, so maybe he can help. Hopefully he’ll be a portal for more testing at very least.
I’ve been referred on the NHS but might try get a private appointment to expedit matters.
- I want to get tested for Candida to rule it out. I explained all of this to my GP and she was almost angry i was asking for a blood test for it. She said we can “rule it out” and that she “wouldn’t be allowing a blood test for it and never has done”. I articulated things well and kept myself composed - i explained that some people have found success here and that, although all of this is left field, my condition isn’t exactly normal. I actually corrected here on a few things without being rude. Either way, it looks like ill have to get this done on my own, im certainly not prepared to take assurances from a GP just because they don’t know anything about it.
So i’ve getting an appointment with a Consultant that can sanction blood tests via Genova Diagnostics. I’m going to try get my candida blood test (maybe stool…yuck!) and a 24 hour cortisol saliva test done. I might even get Reverse T3 and others done via this if i can’t get my endo to do it on the NHS.
- I’ve started a new strict diet. Before my diet was awful and i’ve been drinking far too much. I’m now trying to cut down on alcohol, i’ve cut most sugar out of my diet and im trying to eat healthy as a whole aswell as stay fit. I’m sure this will help my body.
As you can see, i’m now at a point where i’m taking all necessary steps in an all-encompassing approach. I’ve finally come to grips with the idea that I need to look at my body inside out to try fix things, and im prepared to do this.
Fair play to you for chasing the doctors in the UK mate, I wish you the best of luck. I have tidied up my diet myself, but it hasn’t made any real difference.