JN's story -- former 2001 Yahoo Group Member

General Discussion
#281

My succinct update is that I have now injected Mesterolone IM. I have been disappointed with the results, but I stick to the fact that I think it is the best cure for me. (for us). I have injected 25mg twice a day for a couple of days. As it is mesterolone base, it is painful.

I required probably about 500mg per day of Masteron to be perfectly cured. Mesterolone is 4 times more androgenic.

I thus believe I need 150mg per day of Mesterolone (intramuscular). This is quite a lot and I hope my body can take a dose of 1g of synthetic steroid per week for the rest of my life.

I know I need DHT. I really do. I woke up this morning with a real depression as I believe my DHT is low.

I looked my gf in the eye and said ‘I’ll feel better in 10 mins.’ I wiped Andractim on. 10 mins later, I am in much better spirits. A pure physiological response to DHT. I have always been a very sensitive person and can tell my DHT status as soon as I open my eyes in the morning.

I am praying that IM Mesterolone Cypionate at about 1g per week (1 injection per week) will not screw my kidneys/liver up.

We can only hope. Best of luck everyone.
Clearly I am doing my bit for myself and for others. I ask only that if you read this and update yourself with my treatment that you take part in Dr Irwig’s trial. Please.

JN

#282

Hey,

Just going to update everyone before I pop to the gym.
I took 2 measly doses of IM mesterolone which hurt. Should receive the extra solvent to stop the pain in next day or so.

Either way, I’m not going to try Mesterolone again. There is something about these synthetic steroids which I don’t understand; the dose (same with Masteron) needs to be quite high.

In the meantime, Andractim is holding me nicely. The more I take, the better I feel, the better my sexuality etc. Direct correlation. I am taking 15 to 20 grams a day, as cytochrome predicted.

I am very hopeful for DHT heptanoate.

Update soon, take care.
JN

#283

Read the studies I found on DHT Hepan…They are promiment!

#284

Good on you JN. You have just found another thing that doesn’t really work. You have the tenacity of Thomas Edison. Surely one day you will hit pay dirt!

Are you referring to this one? It does look interesting…

viewtopic.php?f=9&t=3663&p=21986&hilit=heptanoate#p21986

#285

Yes…I took this paragaph of the article…take a look below…

We have shown previously (3) that DHT administered percutaneously (125 mg, twice daily) for 3 days caused substantial increases in the excretion rate of DHT and its 5-reduced metabolite 5-Adiol, while decreasing the excretion rates of the hormones T, EpiT, and LH. Similar findings occurred with intramuscular administration, although in general the responses were more marked, a fact we attribute to the larger dose and different route of administration. With an intramuscular route of delivery, all the drug injected is bioavailable, whereas with percutaneous administration, only ~10% of the dose is able to penetrate the skin. Excretion rates of DHT and 5-Adiol rose ~8-fold, maximum excretion being attained within the first 24 h after administration and then slowly declining. T, EpiT, and LH also showed a more marked response with excretion rates decreasing to ~20–25%. This pattern of suppression was consistent with the administered DHT causing a negative feedback effect on the hypothalamic–pituitary–testicular (HPT) axis.

#286

Good posts chaps.

Yes, I agree. I’ve researched the hell out of DHT. There was one chap in the DHT heptanoate trial who strangely was at the bottom of Adiol G range. Then he was given 250mg DHT heptanoate and his Adiol G went to top of range (but still inside normal).

Even more importantly is that I KNOW I need DHT. I take Andractim 3 times a day. It picks me up EVERY time. I feel a sense of calm come over me. If I put on more before bed, I wake up in the morning feeling good.

My point is that I think I require 3 times the stated dose of Andractim due to it’s poor bioavailability, and ITS LOCAL EFFECT. There are lots of DHT receptors in the skin using up the DHT. An IM version of DHT is likely required for that extra target tissue penetration, and yes, I’m encouraged by the more ‘marked’ increase in DHT parameters associated with DHT heptanoate vs gel.

I have been seeing a psychiatrist for over a month. I told her I refused to take antidepressants as I need DHT. DHT is my antidepressant. It enables me to function. My mood has picked up over the last month as I have slowly increased my Andractim dose. I feel good. I told her I was going to prove I had a purely organic cause for my depression, and she is starting to believe me. She is lovely.

I can’t wait to get DHT heptanoate. I’ve told my contact (seems very reliable) that more men may require it.

Keep your fingers crossed. I’m about to take my Andractim before bed! I’m going to get myself better then start rocking. Yes, fucking rocking.

JN

#287

Very sweet dude…do you think 250 mg of DHT per day along with TRT and HCG is safe on our liver? I sure hope so!

#288

Bear in mind it took that dude 250mg to get from bottom to top of range. Hepatanoate ester is dosed twice weekly, but don’t worry, I don’t think we need 500mg per week. I think 2 doses of 150mg per week should be more than enough. The heptanoate (enanthate) ester builds up in one’s system. Possibly as low as 75mg twice a week. Or even lower.

Probably important not to take too much DHT as too much is associated with glucose intolerance

As for TRT/HCG/DH…I hope it’ll be ok. The liver is a very forgiving organ and you have to really smash it for it to not work.

I’d say it’d easily take a constant dose of the above.

JN

#289

Only to say, you’re THE MAN JN !
God Bless you for your Great Effort and Atitude !

#290

Just throwin this out there - what about applying it directly to the prostate then?

#291

JN,

I have a question for you…would injecting DHT Enthate help increase Allepregenolne(THP) levels? Or would we have to take another medication to get those levels up for THP?

So if I’m thinking right… this is an ideal protocol

40-80mg of Test-E(depending on the person) per week
250mg of DHT Enthate per week
500IU-750IU HCG per week
Arimidex(If needed)

#292

Applying direct to the prostate. No, we (or at least I seem to) require DHT delivered effectively for systemic (whole body effects). I believe our DHT has to be IM.

Anonnn1. Yes, I agree.

My proposed regimen will be

Sustanon 100. 50mg per week.
HCG 250iu twice a week
DHT heptanoate starting at 75 mg twice a week
Vitamin D 10,000 iu per day, checking Vit D levels at month 3 and 6.

Hopefully Arimidex won’t be needed, but if E2 is slightly high then DIM could be used. Even broccoli juice.

Of course, all this is dependent on DHT Heptanoate working. Currently, I take 50mg T every 5 days which is great news as Andractim is clearly holding me well.

Keep going chaps

JN

#293

JN out of curiosity would you say the current doseage of Andractim you`re taking
is of greater benefit to you in comparison with Proviron?

#294

Yes, I’d say Andractim is much better. Am able to get away with a normal T when I take Andractim. On Proviron, I’d still require greater than 150mg T per week, and still then I’d be a psychological mess.

Seemingly I require pure DHT. My response to Andractim is quite dramatic; feel better within minutes and can tell during the day when I am ‘low’ and require a top up.

Erections are nearly full, libido not high yet.
Waiting for DHT heptanoate.

JN

#295

Interesting, a psycological mess due to the Proviron or the added T? My order
for Proviron should be arriving this week and I think Ill start at a low dose of 25 mg per day and go from there, apparently there have been many whove reported
improvements on that low dose. I think I may also end up trying Adractim as well, does it matter where you apply that high dose?

#296

I agree that we need to be focusing on Allpreg levels as well as DHT has 5AR effects both of these!
bio.net/bionet/mm/neur-sci/2 … 58929.html

But I am unclear exactly how to do this… the above link says that there was some success with Zoloft.

But regarding your protocol - Am I missing something? Because it seems like the protocol you an JN are developing seems to be some sort of permanent HRT. I thought the plan was to find something that was curative in nature… Or is that what this is?

#297

All this mention of Allopregnanolone, you guys seem to be fixated that this is solely responsible for the mental symptoms, but we don’t know this for a fact. This issue should have solved itself once 5AR2 started regenerating, but if it’s been suppressed as some believe, it could be the cause of that symptom, aside from simple lack of androgen causing lethargy and forgetfulness. I know enough now to say that mental symptoms are a collaboration of deficiencies and defects in neurochemistry, but the question is, is it a result of a crashed HPTA or is it in its own right a problem-causer.

I imagine one would take some progesterone, but if 5ar2 isn’t present to convert, that would cause many side effects.

#298

So 3pm, would it make sense for doctors to have their patients experiement with a DHT replacement therapy + Progesterone, then retest allepreg. levels and 3-adiol G levels until a pattern is established? TRT would be needed+HCG of course.

#299

iwontgiveup- I will not answer your questions as you have not participated in Prof Irwig’s trial. Sorry.

Chris11- You have attempted to participate. Thanks. I shave my abdomen and chest and upper arms. Please read the Andractim trial earlier in this thread which indicates these were the areas of application.

pps- you PM’ed me requesting advice. You have not participated in Prof Irwig’s trial and therefore I won’t advise you. You have seemingly suffered for 7 years and can’t fill out a form to help yourself and others. Sorry.

If DHT heptanoate works for me, (I am having it specially made in a laboratory in China…it took me about 50 hours to organise), I will only offer the contact details to those who have attempted to participate in Prof Irwig’s trial.

Please refrain from posting on this thread if you haven’t attempted to participate in the trial. Thanks.

JN

#300

jn - I appreciate you leveraging to get more participation in the study. You are helping us all. I attempted to join the study when the news first surfaced and was denied eligibility. :frowning: