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M.-J. Chen et al. , “High serum dehydroepiandrosterone sulfate is associated with phenotypic acne and a reduced risk of abdominal obesity in women with polycystic ovary syndrome,” Human Reproduction , vol. 26, no. 1, pp. 227–234, Jan. 2011.
High levels of adrenal androgens appears to also be associated with acne. Interesting that their levels actually rose during treatment.
The question of whether similar changes are present in symptomatic post-Accutane patients remains.