Thanks jqd. One of mclangi’s publications. I think his work is some of the most important as his focus is distinctly on neurochemistry and autoimmunity.
I ve seen this publication some time ago. Raised cerebral estradiol is one issue so one reason some respond to ai.
Progesterone pathways is another and seperate issue too.
Why it continues post cessation is the real issue and what he will determine in his next study. The good news is, is that this has just started this month.
Good news.
pisses me off when all these ppl think steroids are dangerous and deadly,
yeah ANYTHING IS WHEN U ABUSE IT DUH!
if u abuse food thatll kill u too, slowly but it will.
Yeah, but it won t feel as bad as pfs. You ll be happy and fat and fat then keel over from heart disease.
Pfs you just live and suffer.
If you didn’t already see it you need to know that the PFS Foundation is funding another study with Melcangi in charge. One of the methods involved is:
‘assess central and peripheral neurosteroid and hormonal levels’
It’s all here:
It was posted about on the forum at the time. And it is listed here:
pfsfoundation.org/published-research/
It is on PubMed also etc.
I saw that gelhead. Good news regarding new neuro study in Italy.
Finbasteride, I believe in certain men (like us) finasteride causes our brain to believe we have too much 5ar enzymes and induces some form of mechanism to lower the production of 5ar enzymes. This results in not enough 5ar to reduce test to DHT, and DHT regulates estrogen by killing it. This estrogen rises and most importantly on a neurosteroidal level. This shuts down our dht and test and 5ar as our body believes we are producing too much male hormones as when too much are produced, eatrogen is produced. It’s worth noting that dr jacobs confirmed with me that high levels of estrogen shut down male hormones.
I believe this causes us to get caught in a paradox where our system is converting test to estrogen and estrogen is shutting us down. So by taking an AI you can break the cycle and allow 5ar and test and dht to turn back on per say. If you have good hormone levels, that may be all you need. Just remember that not all of your testosterone is being converted to dht, some or most or half or whatever is being aromatized. So even if you lower estrogen, you still are getting less test to dht conversion, that’s where my protocol comes in.
I do believe in your case you should try arimidex for a while and then add some natural testosterone boosters and increase arimidex. As you can see, my theories are backed by studies, so things are just looking more and more like I’m correct, along with the experiences I and others have had.
if cigarette companies have to fund anti-smoking proposls in all its facets
then motherfucking MERCK should be funding these studies and our meds/supps to get us better.
fat chance? yeah right no chance
press.endocrine.org/doi/abs/10.1 … o-23-2-135
THE EFFECT OF TESTOSTERONE PROPIONATE ON NITROGEN, ELECTROLYTE, WATER AND ENERGY METABOLISM IN EUNUCHOIDISM
It seems that researchers chose Testosterone Propionate to treat Eunuchoidism vs Cypionate or Enanthate, a very impractical form of testosterone that requires daily injections, I wonder why they didn’t use a weekly injection such as enanthate or Cypionate? Perhaps they chose it for the same reason I did, its mechanism of action.
nice find JQD. that’s what we call in hockey a real “a score” lol
I didn’t know you were playing santa claus this year dude.
if this shit works out you always got a friend and place to chill in Brooklyn dude
You know I spent my life solving complex problems for important people, the list is hard for a normal person to believe. During a high profile deposition, an attorney trying to impeach me went down the list of things I had done in an attempt to make me look silly. He found out they were all true and he looked silly, this was right around the time I came up with this protocol, and I always said it too. Instead I said “you left out the part where I doubled your client’s company’s size.”
I have learned never to expect anything in return, likely dr jacobs will publish a paper on this and get a reward and I’ll be a post on a forum lol. I don’t care though, but I might start collecting on all the offers for places to stay when I go and visit 
Joking aside, I’ll have an easier time accepting this condition if out of it comes helping lots of people. This is such a horrible condition that if I found something that reverses it and possibly cures it in time, I have to exhaust all methods of proving or disproving it on here. I could have just posted and left, but that’s unlike me.
I’m really looking forward to getting suspension, that will be the begining of something awesome for us all.
Now I know people here say I have a big ego, but I think it only fair if this works for everyone that a statue be built of me. I’m looking in the distance with a sword in my hand and a giant propecia pill cut in half
Thanks for the continued effort and insight, man.
It’s a big step to start exogenous Testosterone, but worthwhile if successful. I’ve lost 9 years here. T prop can be stopped and restarted. Paired with Arimidex or Letrozole, shutdown shouldn’t be too extreme. And restart with clomid/novladex/HCG, if necessary…
This is it.
I’ll keep you updated.
Ps. Just keep letrozole for emergencies, it nuked my libido, however, it depends, arimidex may not cut it for you and Letro may be what gives you your libido. I plan to keep Letro for an emergency estrogen surge and work with arimidex.
If only there were an extended release version of arimidex that would be all we needed and we literally could go on any form of test and move on with our lives. The neuroestrogen rebounds so quickly, but at least we know what these crashes are and how to reverse them.
You know, this is just the begining, the more people get on, the better ideas people will come up with. I know that with testosterone suspension, the game will change entirely. My hope is that I’ll recover to the point that I’ll be able to go back onto a long acting once a week ester. I still am rather interested in the fact that when I was consistently on enanthate I had 3 times where I responded almost normally for a week or 2.
After that I crashed, back then I didn’t know it was estrogen and reversible. I have a lot of reason to believe that consistently stimulating 5ar will result in recovery. I know this isn’t some kind of irreversible damage, and I know it’s repairable. I spontaneously responded to long acting test, I am actually extensively familiar with traumatic brain injury (as much as hormones).
Brain injury doesn’t all of the sudden recover then go back etc… Anyway, Frustrated suggested I not cludder my tbread with more of my theories, he is prob right. I’m excited about the suspension, I’m going to push to have it overnighted Monday somehow. I am also excited when we get reports back from success stories.
hey justquitdut,
first of all i want to thank you for answering so many questions. I would like to preface this by saying i do think this protocol sounds promising. But there is one thing I don’t understand, hopefully you can answer it.
How exactly does this protocol increase 5AR? If we don’t have enough 5AR in our bodies then wouldn’t the AI just prevent the test from converting into estrogen, leaving us with increased test and decreased estrogen? Because we still wouldn’t have the 5AR to convert the test into DHT.
Appreciate the help man congrats on your recovery.
Hi there, thanks, I just need to point out that I am not recovered, I am reversed, there is a difference, I have pfs in reversal, but if I mess up my protocol or stop it I will be full fledged. As for your question, based on my own personal experience and based on others I have spoken to and thresds I read. We have 5ar production, it is suppressed, I have a theory as to why. Anyway, due to the suppression of 5ar it is causing our test to be converted to estrogen. The estrogen is shutting us down, I have first hand witnessed a large dose of test bring me into estrogen dominace and shut down my 5ar and thus dht.
I have been on a large dose of test and induced 5ar production by taking enough of an anti estrogen. That's not just me, I have read that Eden once posted the only way he got an androgen response from test was with arimidex. He never explored that, but lowering estrogen and injecting a highly androgenic form of testosterone (like suspension or propionate) will stimulate as much 5ar as it can and reduce as much test to dht as it can.
So we do have enough 5ar, though it is limited, the problem is estrogen keeps rebounding and shutting it down. I have battled it on an hour by hour basis, I'm still recovering my dht from mssteron use, so I believe I have another couple months before I can gauge where I'm at. For now let me state that if estrogen is kept under control, we may not release enough 5ar as we should, but uninhibited from estrogen, we will respond enough with the exogenous testosterone.
The idea is to push our systems to the max while keeping down the hormone that's blocking everything. The hope and theory is that in time our system will detect low to normal estrogen, high testosterone and low 5ar and low dht. We are creating a reverse of the circumstances finasteride put us in. I'm not sure this is damage as much as our bodies responding to what it thought was an overload of 5ar and lowering production. Then due to it not really being low 5ar and actually being a 5ar blocker, our body became estrogen dominant on a neurosteroidal level.
So we are stuck in a paradox, since the circumstances of a 5ar blocker put us here, it's logical to conclude the reverse would get us out. Also the protocol would allow us to live normally, to reverse pfs so we can have a normal life again.
I was skeptical of my own theories month ago, but now here I am a month later and I have significantly recovered. So far no one with pfs has ever done this, for all we know it could induce recovery in a matter of months. I also devised a nuclear option for a theoretical non responder, however, I abandoned that approach as it requires illegal steroids and impedes recovery and was not practical if I could restart my system.
Ihatepropecia has pfs and recovered his system enough to handle his natural levels. However, he has to use this same protocol to respond to testosterone, he agrees with me that this induces recovery. He has had pfs for years, so he is noticing after running these cycles of testosterone propionate, he comes out more recovered than when he started.thinksteroids.com/community/thr … 134308166/
Interesting article on testosterone suspension, I am gonna have that in my hands this week one way or another!
Hahaha. That made me laugh (bolded part).
I think the studies and the foundation are our only chance.
Also, I have read the thread, and JQD has been promising that numerous patients would be cured for over a month now. Since then, nobody has come forward.
Oh and I am sure that out of the thousands of people reading this thread every week, not one of them has started this protocol, or a bunch have started it and it failed and they just never bothered to post anything huh? Look, I am just posting my progress, theories and experiences with others I am in contact with. Obviously you are too much of a pussy to try this protocol and want other guinea pigs to try it first and come forward, well, since you are a pussy, you will just have to wait till they do.
I have no obligation to prove anything to you, most people who reverse PFS or recover post one post and take off, they don't get Dr Jacobs to prescribe their protocol and then continue to post. I have no obligation to prove anything to anyone, least of all to YOU. This thread already has 2 guys on it who are starting the protocol and working with Dr Jacobs, Lukas and SG, I have heard from countless guys who say that are starting it. I believe it will be months before we hear from anyone, or perhaps they will recover and NEVER post here again. I certainly wouldn't blame them, look what hell I have been through posting here. I have been attacked, demeaned, criticized, called a liar, had my integrity questioned, my background questioned, I have been insulted.
Why on EARTH would ANYONE want to post here after they recover and face douchebags such as yourself? I hope NO ONE posts here when they recover, because I feel people like you waiting on the sidelines for others to try this and post are cowards. I have very little respect for cowards, the least of all you should do is keep your mouth shut if that's what you are doing, just waiting for others to try this and come forward. Certainly no one is going to answer your demands to come forward, no one in their right mind would ever post here and endure what I have endured.
The 2 guys I am working with are active posters here, one is no longer, the other still is, neither of them want the forum to know they are doing this, but they say they will report back when reversed or not. The fact is, that rather than making this a place of support and encouragement, it is a den of vipers. Instead of being positive about a promising protocol that has reversed my PFS and has worked for another PFS sufferer who could not respond to standard HRT due to PFS (Ihatepropecia), people like you have done nothing but mock and attack and criticize.
While you sit there at home typing insults on your computer, I have been working with people and helping them reverse PFS, working with Dr Jacobs, figuring out this condition and finding a treatment that works. Like I said, logic and mathematics dictate that there are numerous people doing this protocol, it is impossible that that is not the case, and I already have heard from Dr Jacobs that many people have contacted him.
I predict most will get better and you will never hear from them, 90% of the guys who have been in contact with me privately have said they refuse to post here as this forum is filled with crazy people and assholes. So keep on with your rude condescending and puerile posts, and see how many people you can encourage to post their recovery stories and face the hellish attacks I have faced. Anyone in their right mind in my position would move on with their life and not continue posting here, but I have a big heart and I can't find myself going off into oblivion without making sure this research is out there. This forum is taxing and dealing with people like you sucks, eventually I will get on with my life and leave this forum behind, there just are some nice people here I want to help before that happens. If you really did read this thread, you would have seen that a few people have posted they are starting this, several I believe have posted that they are doing similar protocols based on these theories. A few guys already responded to these treatments and posted here and we never heard from them again and probably never will.
What you don't realize is that I am in contact with NUMEROUS people from this forum, you are just 1 person posting on a thread thinking you speak for a bunch of people, you don't. Everyone has been in contact with me, and most of them just quit posting here or coming here due to the negativity. I get so many Private Messages on here that I have to delete them all just to get new ones as my box is full. So, to state it more clearly, nobody cares what you want.
So I am sorry that people aren't coming forward fast enough to your satisfaction, maybe you should just stop reading this thread and go read the ones about parasites or eating goat shit.For you guys who are following what I am doing, I cannot stress enough to start taking Calcium D Glucarate, Finbasteride, I recommend you try this supplement, take 3 pills 3 to 4X a day. It is a very healthy and natural supplement, it is in clinical trials as a breast cancer treatment. I started taking it and stopped Letrozole the same day, all I have needed since then have been minimal amounts of arimidex that I took merely for water retention in my face.
This stuff is amazing, I am astonished at how effective it is, and there are NO SIDE EFFECTS, I encourage you guys to google it and read about it. Low doses won’t work, you need at least 1500mg 3 to 4 times a day, you should still take Arimidex, but this will make things a lot easier for you. I really have to insist on this stuff, it can’t hurt, it won’t lower your estrogen too much as it works naturally, astonishing how effective it is.
It works differently than an AI, I can feel it, it is hard to describe, but with an AI you feel the estrogen being lowered, with this you don’t feel anything but just better. My muscle mass and size has dramatically increased since I started this due to it getting rid of so much estrogen and allowing my body to respond to test.
Yeah, I think after 60 pages it’s safe to say that the main focus of this thread/for you should be writing down how you are responding on this stuff over time & cataloging when and how the people who use this respond to this protocol (empirical stuff).
Of course I know how you feel, that you got to talk up your own theories for people who aren’t yet buying into it, but maybe 60 pages of it should be good?
If you feel like, you could write up some kind of summary of your thoughts/discoveries/ideas related to this for people who find 60 pages terrifying. I’m just thinking how we can be more productive and efficient with our time here, no personal attack intended.