None of this means anything for PFS though… everyone that takes that drug is going to get high, it’s basically causing your cells to work way faster no?
Sorry my mistake I had to explain thoroughly, I am investigating this because, also I had a perfect erection last night and today I am getting weak spontaneous erections.
May be a coincidence.
Occasionally I got good erections in night times that’s why I am skeptical yet, last night I also had all night long wet dreams about having sex. This only happened before when I first started aromatase inhibition. I also have nice tingling sensation in my pelvic floor and base of my dick.
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I think anything that causes increased mitochondria activity and cell proliferation is going to slightly improve some PFS sides. Perhaps due to increased cell count meaning increase androgen receptors. Not sure.
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If my dreams did not effected I would say most likely placebo effect. I will test same conditions this weekend I hope I may get the same results.
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Have you tried the protocol of synthetic dht + aromatase inhibitors as stated in the OP of this post?
The OP does not suggest using aromatase inhibitors?
"So I decided to use DHT as an anti-estrogen, I got Proviron and took 25mg a day, I had improvement, because it was regulating my estrogen, and my sex drive I was 80-90% better. "
Just used DHT as an anti-estrogen. Anti-estrogen’s seem to really mess people up. They don’t do me well, they just seem to make me groggy and depressed.
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You’re right
i dropped the prog
forskolin upregulates the estrogen receptor alpha i believe(though it’s an antiandrogen)
and niacin may have improved forskolin bioavailability(which is <1% orally)
similar to what stamets do on his stack
https://medium.com/psychedelic-fiction/paul-stamets-lion-s-mane-protocol-good-news-it-works-3cfd6d9f08b
Watch out for Lions Mane. This mushroom and Reishi are known as one of the main natural 5ARI besides Saw Palmetto.
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Also upregulates some type of AR’s I think it causes an ar modulation.
When both androgens and forskolin were applied together, androgen-induced phosphorylation of the AR was inhibited (Wang & Fondell 2001). In the absence of androgens, PKA activates the AR (Gioeli et al. 2002), an effect
that can be inhibited by bicalutamide and flutamide and is believed to be a consequence of increased nuclear AR levels (Nazareth & Weigel 1996).
https://onlinelibrary.wiley.com/doi/full/10.1038/oby.2005.162
Activators of protein kinase-A signalling pathway influence ligand induced AR mediated gene expression
Rat AR upon transformation in S. cerevisiae, strain YCR1 showed DHT inducible b-galactosi- dase activity (Rana et al., 1998). Utilizing this system, we have examined the effect of the modulators of PKA pathway in inuencing AR- mediated reporter gene transactivation. PKA acti- vators (20 mM forskolin or 1 mM 8-Br-cAMP) or protein phosphatases inhibitor (100 nM okadaic acid) induced the reporter activity only in the pre- sence of androgens (Figure 1). The extent of acti- vation with forskolin in the presence of androgen was S1.5-fold compared to that seen with DHT alone (137.96(39.02) Miller units, mean SD, n 22, in response to 50 nM DHT). However, neither of them were able to activate the basal level of b-galactosidase activity in the absence of hormone. Furthermore, such effects of these modulators could be reversed by kinase inhibitor.
http://crdd.osdd.net/eprints/archives/back_open/documents/disk0/00/00/03/46/01/chakraborti98.2.pdf
What does this mean? Forskolin good or not?
Depends on person I guess…
we have up regulated AR’s Forskolin enhances DHT effectiveness. Yet according to @VinnyG also upregulates ER alpha… But on some type of AR it causes phosphorylation and reduce its activities. This might be good or worse for us. That’s why I will going to test it a little bit more.
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I will try to give this a shot.
I am adding regular Tadalafil to my treatment plan.
Guys, i know many stories about DHT usage. But has anyone here used like OP did? He used too much DMT and says his friend and he is recovered. Maybe thats the trick? Maybe we need big amounts of DHT to kickstart our body to heal and open up the Androgen receptor density again? Has anyone tried high amounts of DHT here? I wish i have guts to try this, but as a mild case if i get worse i would proably kill myself. So im not touching this at least for now.
Also anyome ever contacted with OP? Is he ok now too.
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I am worried after @doomed80’s warnings he said he got same improvements like me but after 10 years his e2 crashed irrecoverably… if I extend intervals my late ejaculation problem returns immediately, I lost some sensitivity and orgasm quality drops.
I am taking pde5 inhibitor for one week Ed improved considerably my fatigue and low mood from cialis are also recovering.
Since I started cialis everyday, my dick is fuller and harder when Flaccid. Weird sensation…
I have restarted forskolin without any problems I am careful about daily coffee dosage so far no problems.
I am taking it for a week i cannot say that it is working. My anxiety is higher also mood swings are steep. Bad is too bad good is too good.
I also stopped Aromasin completely but i am not happy with it refractory period increased considerably with huge sensitivity loss I definitely do not want to live like this i thought aromasin loosing effectiveness yet i was so wrong… Crap i am worried after @doomed80’s warnings but this is not a life. I will try to endure it for several weeks until my cialis trial finishes.
2nd week on pde5 inhibitor
Lots os depressed feelings resolved i got hard erections at nights but sensitivity is really bad.
It really helped with ed. I Last longer and harder.
It is better that single 20 mg for sure.
I am Free form aromasin and in continuous pde5 inhibition for almost three weeks my libido went back to pfs levels, visual lust diminished i got head aches probably because pde5 inhibition. I lost sensitivity on my penis. Also achieving climax became difficult yet erections are way more better. I also lost spontaneous erections and brain dick connection but there are no problems on manual stimulation. I am also more anxious. My depression from first days of pde5 inhibition diminished i am under a lot of work related stress yet my mood is okay.
I thought aromasin lost its effectiveness in long term but i think I was wrong I definitely feel the difference.
Another symptom retuned is muscle aches after exercise. I do same workout but now recovery takes longer and i get muscle pain with same amount of weight.
I did not noticed this exercise related symptom of pfs but after aromasin I understand it now. Some how aromasin eliminated this problem too.
I will continue not to take aromasin according to @doomed80 ‘s warnings i will give time for pde5 treatment.
In short: Aromasin cured muscle pains, anxiety, libido, sensitivity, late ejaculation and visual lust. No help on ed.
It caused mild jaundice for me i reduced dose and effects reduced proportionally.
Becase of long term effects I dropped it completely at this moment.
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It has been a very long time since my last post.
Currently i am off from almost every thing (including pde5 inhibition) except nac niacin and b vitamins supplements.
After my aromatase inhibition trial i recovered from secession of aromasin and my libido absolutely better like i am on aromasin also i kept refractory period and i have my nocturnals back. Unfortunately no luck on Brain dick connection. Despite the danger i am willing to make an another Aromasin run for several months. Something changed, i do not know what.
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I have started Cabergoline / Dostinex i feel Weird. There is Fatigue and weird sensation. I will update after several days to let you know.
First impression is definitely it gives me satisfactory ejaculation, I do not say orgasm yes it is also enhanced but, it might me placebo too early to tell about other effects.
I definitely empty the clip I can feel it and see it, I came a lot, really a lot and I feel and see that.
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