Dear Brother, i do not know that minoxidil has any steroidal inhibition is it possible that you might use some supplements which contains dht blockers or ketaconazole shampoo?
Only Minoxidil. Iām not the only person to have experienced these kinds of sides and I overdosed hard on it. It transcriptionally blocks 5-ar gene expression so it probably works different than Finasteride. But these sides of mine are real and there are studies showing it is an anti-androgen.
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@Zonz brother can you share the link for minoxidil inhibition of 5ar i am really interested.
Also recently i found this on finasteride.
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Itās been known for a bit that Minoxidil fucks people up fam
Thank you buddy.
I am looking for second step what should i use?
Aromasin + proviron
Aromasin + progesterone
Aromasin + proviron + progesterone
Aromasin + testosteron propionate
Aromasin + Testosteron propionate + progesterone
Please share your thoughts.
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Iām doing Testosterone propionate + progesterone but gonna change P4 for MPA
though progesterone improved my mood/sleep a lot i still think itās worth exploring
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How did it improve sleep? Like insomnia? Or waking up refreshed
both, deep sleep went from 10 to 30%
@VinnyG Thank you brother, can you elaborate how much p4 are you taking and how much you plan to take MPA ?
Today i have started forskolin, after three hours i got steep increase in anxiety i had to run when it hit me.
This has never happened before my fingers are still cold but i am managing my anxiety.
I will try to use it for a month if it will not cause extreme anxiety attacks.
Wish me luck.
Thank you for the warning brother.
I feel Weird now my mood mildly elevatedā¦ i have to decrease caffeine consumption while on this. I took 500 mg immediate release niacin after flush anxiety eliminated then i started to feel very positive.
I can say that this stuff is strong like prescription medicine.
Niacin forms serotonin in the brain so that makes sense.
I suspected more from GABA modulation than serotonin, yes it increases Tryptophan hydroxylase efficiency this may be explains secondary mood elevation but, dissolved anxiety while flushing might be GABA or translocator protein related.
Btw wtf i feel real good ā¦
Sense of elevated mood passed i fell normal but more energized.
Same thing happens to me when I take flush Niacin. It is unrelated to PFS. Even people that donāt have PFS feel good after taking niacin.
I am taking niacin for one and a half year but this effect was comparable to stimulant highs it was weird it only happened with forskolin. I took niacin again in the evening, I flushed but, did not get this high feeling again.
I postpone forskolin trial to weekend, i will start it when i was at home.
Iāve found This while i am investigating
Forskolin is commonly used as a tool in biochemistry to raise levels of cyclic AMP (cAMP) in the study and research of cell physiology.[2][3] Forskolin activates the enzyme adenylyl cyclase and increases intracellular levels of cAMP. cAMP is an important second messenger necessary for the proper biological response of cells to hormones and other extracellular signals. It is required for cell communication in the hypothalamus/pituitary gland axis and for the feedback control of hormones via induction of corticotropin-releasing factor gene transcription.[4] Cyclic AMP acts by activating cAMP-sensitive pathways such as protein kinase A and Epac.
It seems niacin doing reverse on some tissue but not all
The therapeutic effects of niacin are partly mediated through the activation of G protein-coupled receptors, including niacin receptor 1 (NIACR1) and niacin receptor 2 (NIACR2) which are highly expressed in adipose tissue, spleen, immune cells, and keratinocytes, but not in other expected organs such as liver, kidney, heart or intestine.[45][46] NIACR1 and NIACR2 inhibit cyclic adenosine monophosphate (cAMP) production and thus fat breakdown in adipose tissueand free fatty acids available for liver to produce triglycerides and very-low-density lipoproteins (VLDL) and consequently low-density lipoprotein (LDL).[25][47]A decrease in free fatty acids also suppresses liver expression of apolipoprotein C3 and PPARg coactivator-1b, thus increasing VLDL turnover and reducing its production.[48]
It seems niacin mitigates some of forskolinās effects depends on tissue.
In brain niacin do not inhibit cAMP eventually this leads increased dopaminergic activation. May be thats explain my high from forskolin
I will reduce my methylphenidate dose at my second attempt.