I’m glad you’re feeling better. I hope your improvements are retained. Cool you’re looking swole again, too! Keep on checking in with your aromasin improvements/changes, please!
Hello Guys, This my forth day on Aromasin 25 so far it is more stronger than arimidex i am able to replicate my first weeks improvement at some level. Thank god i have that funny feeling in my genitals again but, i am unable to crash estrogen. Also my joint pains are eased a lot, almost disappeared.
On this side effect it is way more better than arimidex.
My libido is extremely high almost on hyper sexual levels unfortunately on ed side nothing changed i can became erect but really hard to hold it i am also trying sperm retention. Before aromatase inhibition i was able to hold my self for three weeks and i can hold more now after 10 days i had to ejaculate otherwise i got huge genital pressure and ball pain.
My Psychiatry is really weird i am definitely on down mood that also happened on arimidex in my first week. I am still very tense but at the same time my limb muscles are relaxed so much also i can easily hold my temper it is really hard for me to explode with anger though i have low level constant anger. Again like my first week on arimidex i think sex all almost all the time even in my dreams are sex oriented.
And sensitivity is perfect, i got the most sustained improvement on this.
About my extreme improvement in first week of aromatase inhibition i have a theory. I believe it is related with serotonin depletion and serotonin modulation.
Check this quote;
Finally, the effect of estradiol on mood must be considered. As mood can correlate with sexual interest, it is reasonable to consider these data when discussing the role of estradiol on libido. While cognition, well-being, and depressive symptoms improve in men whose low testosterone levels were corrected,24,25,26 higher levels of estrogen also have been associated with less depression in older patients of both sexes.27 In addition, estrogen supports serotonin levels and affects the amount of 5-HT receptors in the brain, and depending on receptor subtype, there is sexual inhibition or facilitation.28,29,30 A recent study showed a significant positive correlation between endogenous plasma estradiol levels and cortical 5-HT2A binding in men, with no independent effects on these receptors from testosterone.31 In addition, when serotonin binds to these 5-HT2A receptors in the cortex, limbic system, hypothalamus, and midbrain, sexual desire is inhibited with subsequent induction of refractoriness and sexual satiety.32 The interaction of estrogen with serotonin is complex, with overlapping influences that reaches beyond sexual desire including mood regulation and cognition.33 This fact makes its true impact on sexual desire and behavior difficult to fully elucidate.
Man, you completely mad to use Aromasin. Stop it immediately!
[ QuantumFaith”s Blog. Recover or Die Trying (RIP)
Firstly, you might know me from another username here. I have had to change it due to some privacy concerns and i will be posting on this account now. Perfect timing anyway as i have just got my bloodwork back today from my baseline after quitting TRT.
For anyone who should recognize this member, please refrain from revealing the old username. - Enden
[size=5]My Story[/size]
I took Saw palmetto Extract in March 2012 due to rapid diffuse thinning. After about 2 weeks of taking it i developed severe testicular pain and had an ultrasound but it came back as fine. I kept taking the SP because i didnt know it was the problem, then my mood started to swing like crazy. I started to feel hypersexual in April 2012 and i got oil all over my face and acne. I went to a party and had a few drinks and a cone of weed and i had a 8 hour pannick attack and woke up with PFS. At the time i didnt know i had PFS i thought weed caused braindamage or something lol. When i first woke up i had bad brainfog and over the next 6 months all the PFS symptoms started.
[size=5]
Original PFS Symptoms[/size]
Low Libido
Loss of random erections
loss of erection quality
loss of morning erections (only once a week)
Apathy, borderline psychopathic
chronic fatigue
lack of refreshing sleep
lowered body temperature
Chronic Constipation
Joint instability, mostly in the lumbar spine
lack of body hair
puffy face/water retention
Brain fog
severe concentration problems
loss of enjoyment for hobbies
social anxiety
Because all the symptoms developed over 6 months i did not notice how much i had changed, only my friends did. They started to ask what was wrong with me, as i had quit the sport i was becoming an elite athlete in. THey started to hate me and i didnt know why, but now i know. I lost all interest for things that used to excite me like carpentry, snowboarding, engineering etc. I flunked college hard and basically turned into a couch potato. One day in 2013 my friend said he has some girls over and he wants me to come. And i did not want to. This was very strange for me and this is when i knew something was wrong. For the next 2 years i went down the rabit hole with "“Adrenal Fatigue” “depression” and other theories i had for the lack of libido. When TRT did not work that was when i knew something was very wrong with me. I tried TRT for 2 years with no benefits at all. Then in May 2015 i took progesterone cream and i had a full recovery for 3 weeks, literally went through a second puberty and got a job, then i crashed and had to quit. That was when i discovered Propeciahelp because of the progeterone threads and i traced back my transactions and found that my testicular pain in 2012 started 2 weeks after i bought saw palmetto, and the Crash i had was 1 month after. This made me FREAK out and i started to try many things.
I was on JQDs protocal from August to september and i felt 75% better but i had no libido, so i experimented with clomid and for some reason it brought me to 100% but i couldnt maintain it and it gave me some sort of hyper estrogenic effect. I tried taking a tiny dose of arimidex on top and i was 100% recovered. I drove my car for hours crying with joy, i went to the shops and looked at the women like a bull, i rediscovered my WHOLE personality it was fucking INCREDIBLE. I was planning my life, catching up with new friends etc. Then it started to slip away, and i tried another tiny dose of arimidex and it came back, but only lasted 6 hours this time. Because of how PROFOUND this recovery was i could not think properly and i kept redosing the arimidex untill it stopped working at all. So i tried some aromasin and i crashed really bad. I quit them and as i expected i recovered 7 days later and decided to go the natural route at recovery, because this is not sustainable pushing my body into balance when it doesnt want to. Then on the 8th day i crashed again and i have been plagued with SEVERE symptoms on top of my PFS for the past 8 months, which has probabaly ruined any chance of having a normal life again.
[size=5]New symptoms since September 2015[/size]
Extreme connective tissue weakness: Have to wear a neck collar due to cervical instability, cannot bend my back or pick anything up from the floor. By far the worst side effect and the one that leads be to thinking about suicide. I literally cannot turn my head without getting neurological symptoms from the lack of stability in the cervical spine. I have to look straight at all times, and i cannot drive a car anymore. This includes the connective tissue ALL OVER my body. I dislocate my jaw if i yawn, i can sprain the ligament in my eyes if i look to the side too far. Its terrifying. I also wear a back brace and i can only shower twice a week because its very scary. I feel like a puppet, literally. It must be because i triggered another persistent change, but this time in a estrogen pathway, and because estrogen is very associated with collagen synthesis i have suffered severly due to already having hormone problems from PFS.
Severe brainfog, about 50x worse then before
Eye floaters
Visual snow and flashes
Severe orgasm intolerance
Severe fatigue
Depression
Multiple Chemical Sensitivity
Overwhelmed feeling in my brain
Intractable Constipation: Cannot move my bowels without an enema
Supplement intolerance
So what i have essentially done is make my condition go from bearable (i was self sustainable and working, and making a life formyself) to housebound requiring care 24/7. The situation is so incredibly unlucky that i cannot believe it everyday. Its hard enough to get saw palmetto PFS, then to have severe problems from an AI is such ludicrous. My body is severely damaged now
[size=5]Course of Action[/size]
I am now seeing a VERY good functional MD who has ordered a whole host of tests to get me a solid baseline, which i have just posted below. Sadly they dont show much at all. I will be seeing him tomorrow to follow up the tests and start a protocal.I would like to follow a plant based diet with high amounts of juicing but its not possible with my severe constipation. Eating fiber is dangerous and could end up putting me in the ER, if not killing me due to obsructing my bowel. RIght now i am juicing up to 8 glasses a day of organic produce, and im eating organic meats, liver and some cooked vegetables like asparagus. My diet will change as my gut improves. If i can fix my gut i will be able to drastically alter my diet, but for now im eating a gerson/weston a price diet. Using coffee enemas and juices from gerson, and utilizing grassfed fats and meats from weston a price.
The biggest issue for me is connective tissue/collagen. My symptoms are on par with elhers danlos syndrome which is a congenital disorder.
Only difference is i induced it. My DHT stopped working from saw palmetto and my estrogens stopped working from aromasin.
Add in HGH deficiency on top and you have a recipie for collagen disaster. I can injure my fingers by spreading my hands.
My entire gastrointestinal tract is effected too. My rectum is now so weak its almost prolapsing. I have colonic inertia, small bowel dysmotility and now gastroparesis. All found in elhers danlos syndrome.
All of this on top of chemical castration
IF fmt doesn’t work then i want to try boost HGH with mk677 if i can get it. If i can get more collagen synthesis i might be able to stay alive longer. Im getting neurological problems from my craniocervial instability and over time it will probably lead to cranial settling where the head compresses the brainstem causing seizures etc. I’m already nearly blacking out from turning my head.
Its a total nightmare. If i went back to pfs only id love my life forever.
Please keep me in your prayers. FMT is my last hope. If it doesn’t work i truly have no idea what to do. I have no money for stem cells etc… Im degenerating way too fast.
I suspect its all antibody related and with 2 blocked hormomes, fucked connective tissue and totally destroyed gastrointestinal system recovery is impossible.
FMT is it folks. Im praying
@Jaime why not say anything?
For me here you are all crazy.
Be careful people.
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The article is very interesting.
Estrogens are fundamental for us.
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I know him and others that’s why i asked your opinion brother.
And believe me, i am at the bottom and nothing to loose at last crash, i consider put a bullet in to my head and i was definitely not anxious or depressed, just i had enough of this constant downward spiral.
I found this forum and decided to try @JustQuitDut protocol without TRT. I took Half arimidex and 12h later i returned to pre pfs level even my damn visual lust has restored please check my progress in my first week.
When i crashed estrogen i became zombie but, every step i took gives me orgasmic feeling in my genitals, it was that good.
Then i made a break and my estrogen jumped couldn’t crash it again i even took 2mg arimidex per day without success then, i switched aromasin. It is somehow different, it accumulates in time because, slowly my musculoskeletal pain increased but, at same time my libido sky rocketed also, since first days of arimidex i kept my returned sensitivity and orgasm satisfaction.
I really cannot believe how did i live this dull life for 7 years.
Today i hit by extreme ED basically it won’t get up only partial very soft erections and its almost half of its erect-size but, at the same time i can come three times without any problems and refraction period is like 20-40 minutes.
May be in time i will became like our lost brothers or i will end up with totally restored libido sensitivity and if i lucky solved ed.
If you check my hormone levels they are really weird aromatase inhibition did nothing on estradiol but almost doubled my total T and tripled my Free T.
Also on arimidex paradoxically i got very sensitive nipples on aromasin that disappeared.
I can confirm some of QuantumFaiths(R.I.P) symptoms that on first weeks my bowels almost stopped got extreme brain fog i even lost depth perception and hit my car to wall several times also i felt somewhat depressed then it disappeared but, on aromasin i feel more depressed, irritable and more brain fogged than arimidex on positive side i am more goal oriented we will see that if thats dissolved or not.
I am wondering if this extreme ed related with aromasin or circumstantial.
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I think we really need to pay attention to some of the most extreme cases and hopefully learn from it.
Unfortunately I believe this could be a type of disease progression that hopefully the majority never experiences.
I believe what he was dealing with was treatable, he just didn’t know what was going on. Like us all.
I almost see PFS as a experimentally induced condition. At least thats how they might term it in a study. Inducible by 100s of environmental exposures, not specific to the drug itself.
If we can induce this at the drop of a hat, it should be correctable.
4 Likes
I also agree on this. My first self-medication try in my pfs was with a pill contained unknown amounts of yohimbine. I hospitalized after one week.
I was sure that my hearth or vascular system destroyed and i will die. Everybody told me that i am okay, its my brain doing this, but i did not believed them and then i prescribed benzo with snri.
I took half mg Ativan then all symptoms went away…
I took psychotherapy and CBT, i also suspected that my pfs might be psychiatry related but i was assured by two psychiatrist that, ed has nothing related about my psyche and most probably has an organic hormonal cause.
I went back to urologists they told me the cause is finasteride and even with normal hormonal profile that, my androgenic system had accelerated aging and I experiencing symptoms of 60 years olds.
They offer me uninterrupted pde5 inhibitor therapy. i told them okay it works but, i feel nothing. It is like some one touching my arm, not my dick and they say there is no other way. It is because of aging and it will went worse…
I found this site i started research and for aging and obese man aromatase inhibition looks best shot.
I started it and it really restored my libido to almost my old hyper sexual levels also I got back my sensitivity. Ed dissolved then came back and now it is worse but, for sake of my exeptional libido and orgasmic satisfaction i will go on this.
Thanks to my CBT therapy i am not loosing it when i hit by depression joint pains or brain fog. I will keep going and tried to complete 30 week period then, i will start cycling experiments.
And guys believe me Estrogen crash is no joke thank god i was warned by @Trump_1776 and others so i did not panicked when it happened.
You get so tired even gallons of coffe or red prescription stimulants has no effect on it. Though i gladly relive it because of my total pfs remission on it.
2 Likes
I’ve strongly cautioned him against AIs, and to stop if the symptoms get worse. He’s on board and vigilant, and I hope he never feels worse from the AIs, and continues success with them.
My position is to be as cautious and conservative with your remaining health we have left until we know what is really happening and how to treat it. Otherwise, experiment at your risk.
3 Likes
Well i have extreme ed at the moment but exceptional satisfaction in my genitals yesterday i was able to have 5 ejaculations some was between 40 minutes i have hyper sexual levels of libido but at the same time i had extreme ed. I am not taking any pde5 inhibitor. i tried sperm retention may be that effected my ed, now i will push for serial ejaculations.
My main suspicions are venous leak and prostatitis. I suspect prostatitis because i have sharp pain in my rectum while ejaculating and that only happens after some days of sperm retention.
I have recovered from extreme ed, libido still very high i just restarted high dose methylfolate and cut the sperm retention. I am not sure which one effected on my ed recovery.
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@DHT you have recovered in 2 days from extreme ed? I’d like to know if you got morningwood and if you still got it in say a week. Maybe then i’ll start soing what you did.
Tread lightly.
Let me clarify, I hit by extreme ed at first week of my aromasin switch but, i also cut methylfolate and made a sperm retention at same time. I did not panicked restarted methylfolate and cut the sperm retention. Even with extreme ed I can come 5 times in a day with 1h interval.
My libido is on adolescence levels , problem is on ed any way, two days later I’ve recovered. it was like a crash but, only effect is on ed, not libido or mental effects.
Now my morning woods are okay actually they are calming me because I got my full erection size on nocturnals though it is hard to keep it but, I know that I do not have any actual shrinkage.
@DHT So what do you believe cured you? Is it the methylfolate, sperm retention, aromasin, some other stuff that you took/did or maybe a combination? And are your morningwoods still there? and how is your libido now?
Since the start of aromatase inhibition libido and genital sensitivity restored with visual lust.
I can can confirm that porn desensitization is not true it depends on visual lust and libido. At least for me.
If I took cialis I am unable to sleep well for several days because of nocturnals and morning woods. Also with cialis, i have normal sex life.
Before aromatase inhibition I was able to became hard with cialis but, I needed manual stimulation and I can lost erection in the middle of action. My aim is to restore full erectile function without any help from pde5 inhibitors. I think extended Sprem retention and cutting methylfolate both contributed my extreme Ed two weeks ago.
Methylfolate really boosts nitric oxide levels that’s why it causes head aches an nausea on some people.
And be careful Aromatase inhibitors are not like vitamins I have joint pains in all my limbs and extreme conjunctivitis my eyes blood shot all the time also I feel like I am about to became sick probably because increased interleukin6 but I gladly endure it because my perfectly restored libido and genital sensitivity.
3 Likes
And brother i am not cured, I am recovering, I am expecting this step backs. I wish that in the end my worst case scenario is to keep my libido with sensitivity and best case is to complete reversal of pfs I believe it is possible. May be this increase on Ed is like the situation after we quit finasteride body overwhelmed with dht and free testosterone…
Also check this
@VinnyG @Invictus @Trump_1776 @Demon
https://www.nature.com/articles/s41419-019-1724-9
The binding of androgens to the AR increases the stability of the protein, transiently elevating AR protein levels in a variety of cell types22. The expression of the AR in MCF-7 cells usually is rather modest as can be seen in Fig. 3a, b. It can be enhanced considerably by incubation with DHT for 3 days. Surprisingly Exemestane is considerably more effective than Formestane. The western blot results are complemented by immunofluorescence results showing a drastic increase of the AR expression in MCF-7 cells caused by the incubation with the AIs and their derivatives. Immunofluorescence results also show a translocation of liganded AR into the nucleus. In contrast to the control, most AR proteins locate in treated cells nucleus (Fig. 3c). Apparently the induction of the AR is an additional feature of these substances which are able to inhibit the proliferation of ER(+)/AR(+) breast cancer cells through activating AR as androgens.
To confirm that steroidal AIs and their 17-OH derivatives reduce the growth of ER(+) breast cancer cells by activating AR, we investigate whether these compounds can bind to AR protein and promote AR transcriptional activity. As shown in Fig. 4a, 17-OH derivatives of Exemestane and Formestane competitively bind AR with an IC50 of 10.44 and 18.16 nM, respectively. Their affinity to the AR is almost as high as that of DHT (IC50, 4.02 nM).
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A little update, I have increased inflammation and joint paints due to extreme aromatase inhibition but, I am trying to endure it. I am in constant pain but it is endureable.
On Ed nothing changed.
I still have restored penile sensitivity, refractory period and excellent libido these things are fixed by arimidex and Aromasin.