BC007 a promising medicine

Keepyourheadup · October 5, 2023, 3:28pm

BC007 is a medicine treating long covid. It is still in an early stage. I read somewere on Reddit that this is the most promising treatment for PSSD. So wondering if this is the same for PFS as it targets auto antibodies

I will try to get it prescribed by my Dr. So fingers crossed

LazarusRy · October 5, 2023, 4:29pm

Keep us posted, of great interest!!!

gomesemog · October 7, 2023, 9:51am

i dont think ur doc will prescribe it since its on tests phase

Exsexgod · October 7, 2023, 3:43pm

First Prof. Luisa Gutteri from Uni Milano jumped on the long Covid Train. Than Risto Roine from Uni Turku. Threir theory auto antibodies triggered by the contact from Covid spike protein with the ace2 protein docking site in human cells causes pfs, pssd, long covid and CFS. Bloodwashing 2.800 € by wash cycle is the therapy for all of it. The sophisticated immunglobulin wash costs 48.000 €.

But next Year comes BCO07 from Berlin Cures what heals all without bloodwash. So best thing, waiting for the BC007 cure for all and donate the money for identifying what pfs is and find a fact based cure. I do that not for me but for the wonderfull fighters, who fight for all of us and estsblished a scientific council with 11 imternational established researchers for pfs studies.

Keepyourheadup · October 8, 2023, 5:44am

Thanx for your complement.

Do I understand that a bloodwash for 2.800 euro is a cure? Sounds to good to be true.

Good point about BC007, donating and the 11 researchers
I think we are at a very promising stage now!

orthogs · October 8, 2023, 11:06am

Show me a single piece of evidence that PFS or even PSSD is linked to the existence of specific autoantibodies.

Exsexgod · October 10, 2023, 10:03am

No for the devil, that was a joke!!

There is absolutley NO EVIDENCE

for HCG, BLOODWASH, BC007

that this can cure pfs or pssd.

Fiercebully9 · October 10, 2023, 3:17pm

There is also no evidence it’s not. There are many ways an autoimmune disorder can happen. They are not all linked to the tests we think of. New autoimmune disorders get discovered that’s how science works. Look at the post statin muscle wasting syndrome.

Fiercebully9 · October 10, 2023, 3:17pm

What do mean you’ll try and get it prescribed? Who is your doctor?

Keepyourheadup · October 12, 2023, 5:35am

Yes, the best thing is stay in the negative mode and don’t look into potential cures.

Sarcastic mode off

Some members over here have given up all hope and want to project this feelings to others. Sad.

Exsexgod · October 12, 2023, 12:11pm

The absolute opposite is the truth!

Selfish self-experimentation will never bring a solution for everyone. Even blood washing without knowing what PFS and PSSD actually is, is a lot of money for treating a disease that you don’t even know about yet.

For thirty years “the silence of the lambs”, no videos, hiding in the dark, spending money only on self treatment and 10,000 young men losing their lives because no one spoke up. 30 years of pointless pseudo therapies because no one has researched the basics.

So better to solve pssd and pfs than invest all the money in every new desperation medication. We have a chance to solve it.

And yes, I don’t feel very good with pfs and like others who don’t want to be silenced I detiroate away for 2,5 years now. But I don’t try to lie it away. I try to support help for all, with monthly money donations, engagement in different initiative groups and awarness to warn all the 10.000th of potential new innocent Hims, Keeps, Organon victims.

Spirit of optimism

Fiercebully9 · October 12, 2023, 5:29pm

If bloodwashimg has worked for someone i need to know. I have skin missing progressive from my face an actual hole.

Keepyourheadup · October 12, 2023, 6:01pm

Thanx for comment, your effort and donations!

Hopefully we will - and I think there is a good chance - beat (partially) PFS. It doesn’t matter if it’s by accident, BC007 or with the research from the PFS network.

Exsexgod · October 14, 2023, 11:43am

BC007 Long Covid Medication should also heal pfs, pssd, cfs, heard and kidney diseases caused by auto immune antibodies against the Covid Spike Protein Docking Site in human cells.

BC007 is hopefully not so expensive as Bloodwash 2.800 € and IG Cleaning with 48.000 €. So no problem, no one should break the journey, no one should stopp other approaches.

But the last 30 years showed that every try and error and quick fix approach without fundamental understanding about the genetical predisposition and the patho mechanism and it’s downstream effects has been a big fail. But the boys don’t want a cure or a banning from the poison I guess, they only want a quick fix for themselves.

Henrique · October 14, 2023, 3:27pm

show in pic

Keepyourheadup · October 14, 2023, 7:49pm

I think it’s to go both paths. Try other approaches, but also donate

cok07310 · October 15, 2023, 6:21pm

There doesn’t seem to be any evidence this drug cures PSSD, but if it wasn’t expensive I would try it

Taw · November 3, 2023, 4:07pm

Been biting my tongue, resisting replying, but I give up, so here goes: It is medically and scientifically known and documented that statins (cholesterol drugs) are definitively linked to autoimmunity and auto-antibodies. Therefore, it’s entirely logical to suspect the same might be true for the various substances we took.

https://www.hopkinsmedicine.org/news/media/releases/statin_use_linked_to_rare_autoimmune_muscle_disease_study_finds

Although statins are tolerated by most patients, about 5 percent who take them experience muscle pain and/or weakness severe enough to warrant stopping the medication. Most of those people will make a full recovery once they are off the drug, but there appears to be a group who will develop this progressive autoimmune muscle disease. They get weaker even after the medication is stopped, some end up in wheelchairs and at least one has died. Immunosuppressive therapy with steroids or other drugs are effective in reversing the disease in most patients, Mammen says.

In his initial research, Mammen and his colleagues focused on 26 patients at the Johns Hopkins Myositis Center with necrotizing myopathy, a muscle-wasting disorder with no known cause. Sixteen were found to have a previously unknown antibody. Of the 16 patients with this novel antibody, 12 were over the age of 50 and, of those, more than 80 percent had taken statins before their muscle pain and weakness began. The frequency of statin use in patients with similar muscle diseases is significantly lower. In his latest research, Mammen identified the target of the antibodies as HMG-CoA reductase, or HMGCR. HMGCR is the enzyme responsible for making cholesterol — and it is the same enzyme that statins target.

In their collection of over 750 patients with muscle symptoms, 45 patients with HMGCR antibodies were identified. Of those over 50 years of age, greater than 90 percent had a prior statin exposure. The younger patients, he says, had not been on statins, and how the disease is triggered has not been determined. However, Mammen suspects that they may suffer from other cholesterol issues, a factor that could play a role in the development of the disease.

Antibodies are typically made by healthy people to recognize and destroy foreign invaders. But in patients with autoimmune diseases, the body makes auto-antibodies — antibodies that attack the body’s own proteins. In the case of statin-associated autoimmune muscle disease, the body attacks its own HMGCR. When a patient takes statins, HMGCR levels rise as the body tries to compensate for the reduction in the enzyme caused by the medication. Mammen hypothesizes that the extra HMGCR in the body may sometimes stimulate the immune system to make autoantibodies.

Compounding the problem is the finding that while normal muscle tissue makes low levels of HMGCR, regenerating muscle cells make very high levels of HMGCR. This suggests that once the autoimmune muscle disease process is initiated by statin use, high levels of HMGCR in regenerating muscle cells continue to fuel the aggressive and painful autoimmune response, even after statins are withdrawn.

Although doctors don’t yet know how many people have statin-associated autoimmune muscle disease, Mammen and his colleagues believe it is rare. Even in the Myositis Center, just four percent of patients have been diagnosed with it. Mammen says the lab test he and his team have developed, which has not yet been approved by regulators, enables them to diagnose the disease with near certainty.

And yes, I 100% know a tissue biopsy would reveal people who have post-statin syndrome and those who have never taken statins will have gene expression differences. It’s basic, common sense that all disease states will have gene expression changes compared to healthy states.

Cbrandel · November 3, 2023, 11:18pm

I’ve heard about the post statin issue before but never realized how close it is to the proposed etiology of PFS.

I mean the blocking of the enzyme leading to an increase/overexpression which then leads to dysfunction/autoimmunity.

Obviously it’s hard to deny and say they’re healthy and it’s all in their head when they’re wasting away and end up in a wheelchair.

Much easier to claim it’s all in our head with loss of libido/pleasure/drive and other non-measurable symptoms even when they’re very real. And while we have physical symptoms here as well, they tend to be not as disabling as described above, which again opens the door to denying. Even when some 20-30 year old have degenerative signs in their penile tissue for example which is certainly abnormal.

Taw · July 11, 2024, 10:53pm

It has come to my attention that the link is broken, so here is another link: https://gazette.jhu.edu/2011/01/31/statin-use-linked-to-rare-autoimmune-disease/

Look at how it emphatically says this is “rare”. I roll my eyes to that. Everything is “rare” until it happens to you. Recovering is also “rare” until it happens to you also.

Johns Hopkins researchers have discovered how statins, the most commonly prescribed class of medication in the United States, appear to trigger a rare but serious autoimmune muscle disease in a small portion of the 30 million Americans who take the cholesterol-lowering drugs.

Taking statins, they found, can sometimes cause the body to produce antibodies against its own proteins, creating a condition that gets progressively worse, not better, even after the medication is discontinued. As the painful and debilitating disorder is uncommon and can be treated with steroids and other immune-suppressing drugs, the Johns Hopkins researchers caution that people who must be on statins to reduce serious risk of heart disease and stroke should not avoid the drugs.

“We have long known that there must be environmental triggers to the development of autoimmune disorders,” said Andrew L. Mammen, an assistant professor of neurology and medicine at the Johns Hopkins University School of Medicine. “Now we have evidence that this medication is just such a trigger and, under certain circumstances, provokes a sustained autoimmune disease.”

Beyond their “proof of principle,” Mammen’s findings, published online in the journal Arthritis & Rheumatism, could lead to lab tests that identify early autoimmune muscle disease, guide treatment before symptoms escalate and, possibly, predict who is at risk before statins are prescribed.

Mammen cautions that the side effect described by the Johns Hopkins research is rare, noting that statins are a “fantastic medication” that have proven value.

“No one who needs statins should be afraid to take them because of the slim risk of developing this autoimmune disease,” he said. “Statins save a huge number of lives. They dramatically reduce the risk of strokes and heart attacks. The ultimate goal of our research is to determine before patients start taking statins who might be sensitive to the medication and who might be susceptible to its potentially toxic effects on the muscle. We want to prevent this autoimmune disease.”

Although statins are tolerated by most patients, about 5 percent who take them experience muscle pain and/or weakness severe enough to warrant stopping the medication. Most of those people will make a full recovery once they are off the drug, but there appears to be a group who will develop this progressive autoimmune muscle disease. They get weaker even after the medication is stopped, some end up in wheelchairs, and at least one has died. Immunosuppressive therapy with steroids or other drugs is effective in reversing the disease in most patients, Mammen says.

In his initial research, Mammen and his colleagues focused on 26 patients at the Johns Hopkins Myositis Center with necrotizing myopathy, a muscle-wasting disorder with no known cause. Sixteen were found to have a previously unknown antibody. Of the 16 patients with this novel antibody, 12 were over the age of 50 and, of those, more than 80 percent had taken statins before their muscle pain and weakness began. The frequency of statin use in patients with similar muscle diseases is significantly lower. In his latest research, Mammen identified the target of the antibodies as HMG-CoA reductase, or HMGCR. HMGCR is the enzyme responsible for making cholesterol and is the one that statins target.

In the researchers’ collection of more than 750 patients with muscle symptoms, 45 patients with HMGCR antibodies were identified. Of those over 50 years of age, more than 90 percent had a prior statin exposure. The younger patients, Mammen says, had not been on statins, and how the disease is triggered has not been determined. He suspects, however, that they may suffer from other cholesterol issues, a factor that could play a role in the development of the disease.

Antibodies are typically made by healthy people to recognize and destroy foreign invaders. But in patients with autoimmune diseases, the body makes auto-antibodies: antibodies that attack the body’s own proteins. In the case of statin-associated autoimmune muscle disease, the body attacks its own HMGCR. When a patient takes statins, HMGCR levels rise as the body tries to compensate for the reduction in the enzyme caused by the medication. Mammen hypothesizes that the extra HMGCR in the body may sometimes stimulate the immune system to make auto-antibodies.

Compounding the problem is the finding that while normal muscle tissue makes low levels of HMGCR, regenerating muscle cells make very high levels of HMGCR. This suggests that once the autoimmune muscle disease process is initiated by statin use, high levels of HMGCR in regenerating muscle cells continue to fuel the aggressive and painful autoimmune response, even after statins are withdrawn.

Although doctors don’t yet know how many people have statin-associated autoimmune muscle disease, Mammen and his colleagues believe it is rare. Even in the Myositis Center, just 4 percent of patients have been diagnosed with it. Mammen says that the lab test he and his team have developed, which has not yet been approved by regulators, enables them to diagnose the disease with near certainty.

Some of his patients, however, continue to need the very medication that caused their pain.

“One of the questions that remain is, Can you safely restart statins? It’s important because some of our patients were put on statins for very good reasons, like they’ve had a heart attack,” Mammen said. “We would like to find out if there is a way for these patients to begin taking the medication again.”

The research was supported by the National Institutes of Health, the Passano Foundation, the Ira Fine Discovery Fund and the Dorothy and Donald Stabler Foundation.

Other Johns Hopkins researchers involved in the study are Tae Chung, Lisa Christopher-Stine, Paul Rosen, Antony Rosen and Livia A. Casciola-Rosen.