Baylor study questions

sorry, im super tired right now and confused

so neither part 1 or 2 are published, but we hope that the full thing gets published in the next few weeks?

thanks a lot

Hi Aaronf. Short question. Where is your youtube Video?

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@Arg1819 please take the survey as it‘s meant to help us to stimulate scientific research. Thanks

Donde se encuentra? Gracias.

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Is this the Baylor Study? https://www.pfsfoundation.org/news/penile-vascular-abnormalities-found-in-majority-of-pfs-patients-in-baylor-college-of-medicine-study/

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Looks like to me…

That is study 1. Study 2 deals with epigenetics and has an unknown publish date.

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Yeah, but this is published now, and for the epigenetics study will have to wait 10 years more :slight_smile:

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Its ridiculous it took that long for that bullshit of a study to be posted makes 0 sense

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“Since two of the PFS patients (8%) committed suicide during or after the research period, Khera suggests that “psychiatric side effects and the risks of finasteride use in patients with a history of psychiatric disorders should be investigated further…” Who said they had a history of psychiatric disorders? They did?

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I agree this quite upsetting. Seems like he’s pointing at underlying mental illness when its not required at all for this to end someone. I guess it doesn’t help but it just sounds like things drugs companies use to justify themselves. It causes mental illness, not just amplifies whats already there.

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OK, I am wondering why after the release of the Baylor study there is such a silence here on this website? I mean, so many years of anticipation and then all of a sudden silence, like nothing happened. :neutral_face:

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@tisho1012 I spoke about this in another thread.

This study Baylor study, part 1 - Penile vascular abnormalities in young men with persistent side effects after finasteride use for the treatment of androgenic alopecia. 2020 is a publication from Baylor. When the foundation announced a “major clinical study” with Baylor, these were the areas of investigation outlined

Methods: To (i) evaluate sexual and psychological function, (ii) assess hormone levels, (iii) measure penile hemodynamic and sensory parameters, (iv) study androgen receptor genetics and gene expression, and (v) and determine gene expression patterns and profiles.

https://www.pfsfoundation.org/news/clinical-study-of-post-finasteride-syndrome-launched-at-baylor-college-of-medicine-2-2/

Obviously not all of that is covered in the recent publication so hopefully there is more to come. I am not a spokesperson for the foundation or Baylor college of medicine. This is just my deduction, based on what information is already available.

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He’s not saying that these patients don’t have PFS, they had underlying psychiatric illnesses prior to taking PFS. He’s really just presented the facts and data because they could be useful. If we find out that having a pre-existing psychiatric illness increases the risk of getting PFS by 10-fold, that’s very useful information. Not just to people who are considering taking the drug, but also to us because it might suggest places to look where things may have gone wrong.

It does sound similar to PFS deniers and legal arguments that Merck would have tried to make in the litigation, but they’re actually quite different. From a purely scientific perspective it may add valuable information. These types of findings can be twisted and distorted and misinterpreted, but he’s not looking to discredit PFS at all.

Maybe having depression is the factor that makes you vulnerable to finasteride, but finasteride is the actual cause for making the situation 10x worse. But maybe there is no connection at all.

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People had their expectations too high and were hoping for at least a breakthrough but didn’t understand what Dr. Khera’s study was supposed to be. The main purpose was do study epigenetic and genetic profiles of PFS patients. The first part which was published basically just described the patients in the study. He found they had objectively measured abnormal penile function so that was worth publishing in a separate study. The other more important study has yet to come.

I don’t know if it will have a breakthrough or how long it will take to come. The pandemic has certainly pushed everything back by months, at least.

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Thanks for clarifying I haven’t read the paper yet I’m too messed up- I was just going by the quote. I hope you’re right. I’m going to read it properly before forming my opinion.

How can underlying mental health issues via depression cause a predisposition to PFS I’m sorry but I’ll have to kindly disagree with that statement.

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You are absolutely right.
It can unmask underlying disorder or makes manageable situation unmanageable via altered neurosteroid balance…
It is like some people do not have bipolar disorder but sometimes some SSRIs causes manic shift and you will diagnosed as Bipolar.
Otherwise you might live a life without taking any SSRIs and people know you as a anxiety/panic or a depression patient.

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The data there shows a real correlation that is worth exploring.

Many of the neurosteroids that are blocked by finasteride are responsible for regulatory stress, mood, and anxiety. If somebody is already putting pressure on their neurosteroid system because of a psychiatric illness, finasteride could be the force that causes some kind of breakdown.

Even if this is wrong, there may be some other explanation that may demonstrate an actual causal connection. Mood issues also interact with hormones for example. Stress and testosterone are connected.

If this is a real causal relationship, it does not in any way suggest that PFS is not real or that it is the person’s fault just because they had a pre-existing condition.

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