A demethylating agent might help depending on what the problem is. We just don’t know for sure yet. One issue is that without targeted DNA demethylation, we can’t be sure we are having sufficient effect to turn the suspect gene back on without damaging off-target effects. I think it is too speculative to undergo a treatment of this calibre without having a therapeutic target in sight first. Some people are doing these types of treatments because they were popular for some time in the CFS community and some were seeing relief from treating a suspected lack of methyl donors based on 23andMe data showing that they had lower-functioning copies of methyl-donor producing genes. I got burnt badly last Summer by playing around with methylation supplements simply based on some other PAS patients saying they felt more energetic while taking them. I’m still suffering the effects and regret being that stupid.
We don’t have a problem due to bad genetics though, only a possible increased susceptibility. We were all fine before taking whatever caused this condition to develop in us.