“The unexpected result of our present study is that the AR upregulation was detectable in the dermis of subjects long after discontinuation of finasteride use, on average at almost 5 years (mean 1672 days) of drug wash-out, in a range from 8 months to over 8 years (240 to 3010 days). Contrariwise, the hormonal alteration effects of finasteride have been reported to be shortly reversible. In fact, according to drug information provided by Lexi-Comp., after 6 months of treatment with 5 mg/day finasteride the circulating DHT levels are reduced to castrate levels without significant effects on circulating testosterone and levels return to normal within 14 days of discontinuation of treatment. An intriguing observation of our study was that the ratio of AR positive stromal cells (%) to serum total or free testosterone was 2-fold higher in former finasteride users than controls. This finding could indicate the presence in former finasteride users of an augmented regulatory feedback loop that normally serves to modulate hormonal responses –. Such amplification of AR levels in respect to serum testosterone levels could derive from hormonal ipo-response in the genital tissues. However, we cannot presently exclude that this apparent upregulation of AR expression is due to local low levels of androgens (particularly DHT) .” (Carla Di Loreto Francesco La Marra Giorgio Mazzon Emanuele Belgrano Carlo Trombetta Sabina Cauci. Immunohistochemical Evaluation of Androgen Receptor and Nerve Structure Density in Human Prepuce from Patients with Persistent Sexual Side Effects after Finasteride Use for Androgenetic Alopecia, June 24, 2014 https://doi.org/10.1371/journal.pone.0100237).
Moment. is it true, if I had a loss of androgens on the penis because of the gel that applied Diethylamine Salicylate is Antiandrogen?, did it modify my penis and brain AR? WTF?
Someone can help me to understand if the substance is antiandrogenic?