From various research, it seems concluded that Accutane strongly induces the p53 enzyme. This causes a cascade effect which then induces foxo1/foxo3, this then causes a significant increase in aptosis/cell death and also the downregulation of igf1/androgens/androgen receptors. We know accutane induces aptosis due to the up regulation of foxo1/p53/foxo3, all anti cancer targets. We also know that said targets result in heavy anti androgenic affects, igf1 downregulation, dht downregulation, 5ar downregulation, androgen receptor downregulatiom etc. This could (partly) easily explain the hormonal/endocrine issues that accutane causes. Now, to the other point, aptosis and cell death. Accutanes indiscriminat aptoptic properties target multiple cells. Cells in te hippocampus/brain, cells in the gi tract, mucosa cells, intestinal cells…etc. Increased aptosis in all of these areas could come with multiple issues and side effects, depending on the location of said cells. What do you guys think? Think this could be a major factor in accutanes mechanism of action, in regards to multiple debilitating side effects.
Also, suppression of p53 helps immensely with chemo sides https://www.ncbi.nlm.nih.gov/m/pubmed/10702639/