Accutane; P53/foxo1/foxo3 the key?

# Isotretinoin and FoxO1: A scientific hypothesis
https://www.researchgate.net/publication/51824313_Isotretinoin_and_FoxO1_A_scientific_hypothesis

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this is an an excellent article–my doc used it to help me get disability

Man, i have very limited knowledge. When you say Fox01 distrupts AR function, does this mean it distrupts the androgen receptors in the whole body?

Or particular affected tissues? Can you explain a little bit if you know the answers.

How did you manage to get disability please In detail