What i am doing now to try and get back to 100%

Therapeutic Efforts Pharmaceutical
#121

No bueno mi amigo

completely no libido and complete shrinkage. its BAD… and I havent had any relief in a while

I finished the PCT and things were looking up … I got a test of Testosterone, LH FSH and Estradiol and everything was in range. I have succesfully restarted my HPTA. Testosterone at 777 (300 - 900).

the only thing I can think of that changed from when I was feeling good and had some libido was the GI MicrobX. That stopped and now I am taking probiotics.

I have a ultrasound scheduled for tomorrow to look for prostatis. I hope this is it because its the theory that makes the most sense to me. There is a ton of correlation between ED and prostitits available online.

I was so fed up with this that I took a shot of testosterone - only 100mg - a couple days ago and i dont feel a thing - if anything I just want to get my mojo back because my life was at least manageable and was getting laid before on TRT… . whereas now I am dbag zombie head

Wish me luck!

EDIT also in hindsight i am looking through my log to find out what may have caused my temp receovery and I didnt mention (because at the time I didnt think it had ANYTHING to do with it) but I caught the FLU right then too. I was SICK I mean REALLY SICK but my dick was working I just didnt think that was relavant at the time i was posting it but i feel like its all coming together as far as thinking its been prostatitis this whole time and trying to attack everything hormonally was not the best thing (although I am glad I did so I didnt kill myself)

#122

Look iwontgiveup, this is insane what you’ve been doing. All of us here in this forum learned how medications can permanently screw us up. We learned how putting unnatural chemicals and substances into our bodies, especially ones that mess with out endocrine systems can damage us. This is not a cure, this is a treatment. And you jump like a maniac from one problem to another, from one medication to another. I’ve been reading this thread from the start and from the very beginning it looked like a train wreck just waiting to happen. As if Fin wasn’t bad enough, you now take so many medications, each with their own horrible side effects that have been biting you and will bite you later on so that you’ll have side-effects x100. A cure is when you can go back to your normal routines and normal life and no longer suffer from the illness. This isn’t a cure, because if you come off these medications you are in for a total disaster.

I would also suggest to stay away from psychiatrists because they view behaviours as a problem that can be solved with drugs. I personally think psychiatry (“medical treatment of the mind”) is full of quackary (and I’m not a Scientologist) since every year they come up with new behaviours to call disorders and new ways to push drugs on clients (ahem customers). If you are feeling depressed (which is a normal human emotion by the way, nothing wrong with that!) but it’s effecting your life negatively, you should see a clinical psychologist. A good psychologist won’t push more drugs on you, potentially damaging your brain the way Fin has damaged our endocrine system. A psychologist will treat you from a humanistic and behavioural point of view, giving you the tools you need to manage your emotions without medications.

#123

How did the ultra sound turn out?

#124

He wouldnt do it! I got there with the printout from this forum. he would look at it. He said it was all nonsense and there is A) no way to tell about bacteria or inflamation in the ultrasound B)prostate problems would come with different symptoms not these symptoms. He said at some point - “iwontgiveup, I get paid to do this ultrasound. I have an interest in doing this to make money but I am telling you that you dont need it.” i was in tears at this point (without the testosterone I suffer from profound sadness and cry at the drop of a hat) and he said he would book me with their andrologist. Thats in a couple days. I couldnt take it anymore so I shot another 100mg of Test and I least shook the fatigue but didnt help the ED. I am going to go to the andologist with more ammo. The ABC news story and the Irwig report as well as the forum thread about it. And if I can create legitamacy he may have interest in futher diagnosis…

#125

Forum threads are not evidence, they are simply people’s opinions. Bring published studies with you. There are plenty in the Finasteride Studies section, as well as the recent papers from Traish and Irwig.

#126

good point. I was trying to bring something about the idea of prostatitis to show him…

#127

In response to this :

This isn’t a cure, because if you come off these medications you are in for a total disaster.

I was a total disaster before any treatment so at least i havent killed myself. I know i would have had committed suicide by now - the sadness is unbearable.

I appreciate the comments about the psychologist vs psychiatrists because he offers little in the way of tools to cope with my new life. Just drugs you are right. I just left a message for an appointment with a psychologist.

#128

I know exactly how you feel.

Testosterone won’t fix us. The problem is much much more difficult to understand than 99% of doctors realize… it’s even more difficult than many of the scientists I have heard of and met with realize and these are people actively researching this drug.

My Testosterone was 822 last time I checked… by all accounts from Uro’s and endo’s I should be ready and willing to screw at a moments notice. I feel no desire, and it takes considerable stimulation to get an erection. These idiots have no idea what they are dealing with when they are dealing with finasteride. Merck itself didn’t know the exact mechanism by which finasteride inhibits 5AR2 when they released it. Its unreal that they would have a drug out there but its unknown exactly how it inhibits the enzyme…

Its like engineering… engineers need to know how something works before they put it into action. Well it appears the bio-medical community is different. It wasn’t necessary for them to understand how fina worked chemically just as long as it did as intended.

#129

Ive been a mess i didnt goto work for 2 weeks and didnt clean my house or nothin

Okay so I shot 300mg of Testosterone Cyp because I was going crazy. This time I am also taking toremephene to eliminate the estrogen rebound problem that appears when i take the testosterone. 2 days after the shot I had to change my belt notch up one because it bloats me that bad. So I decided to add a SERM to give the Testosterone an even playing field

So when I took it, it was like climbing out of a deep dark dungeon and into a bright beautiful grassy field with bunny rabbits and butterflies

I cleaned my house, went to the gym and went a bought a new printer (mine was broke) and bought a 3ring binder and clear inserts.

I printed out all of the news stories, medical studies and the doctor’s commentaries about PFS. I printed out the symptoms of androgen deprivation and some information about the role of androgens from NHIS. I went through it all and highlighted the main points. I put the papers in the clear inserts and now I have a light presentation to give to my andrologist appointment.

I consider the appointment to be a success. Not because he had a cure, but because he didn’t brush me off. He was receptive to the idea that there is stuff out there he doesn’t know about. He went and got me 30 cialis from the back and recommended a specific psychologist not because of him thinking its in my head, but to deal with the impact this has had on my life and talk to someone. He agreed that he can help me monitor my treatment and wants to take some blood tests the day before my test injection and the day after. I left feeling good, that I had someone who was at least willing to help me feel better while we wait for a cure. And its on my insurance which is huge.

If it wasnt for the testosterone I dont think i ever would have put together that whole presentation and this outcome would have probably like all of the others.

Still have ED. Shrinkage getting better - its not 100% impotence any more at least… but its okay. at least i can shake all of the other sides. i will just have to use trimix for now i guess

I also ordered something new today because of this from WIKI that I found when I was looking for stuff to bring to the visit:

Androgen binds with the androgen receptor.

The androgen receptor is expressed ubiquitously throughout the tissues of the human body.

[Size=4] Before it binds with an androgen, the androgen receptor is bound to heat shock proteins.[/size]
These heat shock proteins are released upon androgen binding.
Androgen binding induces a stabilizing, conformational change in the androgen receptor.
The two zinc fingers of the DNA-binding domain are exposed as a result of this new conformation.
AR stability is thought to be aided by type II coregulators, which modulate protein folding and androgen binding, or facilitate NH2/carboxyl-terminal interaction.

Looks like androgen cant bind to the receptor unless it is first bound to heat shock proteins. Also found an article about HSP as it relates to ED -
ncbi.nlm.nih.gov/pubmed/15093712

[i]J Surg Res. 2004 May 1;118(1):21-5.
Sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of the heat shock-related protein 20 (HSP20).
Tessier DJ, Komalavilas P, McLemore E, Thresher J, Brophy CM.
Source

Department of Kinesiology, Arizona State University, Tempe, Arizona 85287, USA.
Abstract
PURPOSE:

Sildenafil is an oral phosphodiesterase type 5 inhibitor that is a vasodilator used in the treatment of erectile dysfunction. Cyclic nucleotide-dependent vasorelaxation is associated with increases in the phosphorylation of the heat shock related protein 20 (HSP20). The purpose of this study was to determine if sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of HSP20.

RESULTS:

Sildenafil induced vasorelaxation of pre-contracted coronary artery in a dose-dependent manner. Sildenafil-induced vasorelaxation was associated with an increase in the phosphorylation of HSP20. Transduction of peptide analogues of pHSP20 led to a dose-dependent relaxation of pre-contracted porcine coronary artery.

CONCLUSIONS:

These findings suggest that sildenafil-induced vasorelaxation is associated with increases in the phosphorylation of HSP20 and that transduction of phosphopeptide analogues of HSP20 is sufficient for relaxation of vascular smooth muscle.
[/i]

So could it be that the Androgens cant do anything without HSP? They cant get to the AR? Well we keep trying to increase the androgens, and I searched and it doesnt look like anyone on here has thought of increase HSP instead. So I bought some MRI HSP activation shit on Amazon. $31 USD not too bad I figured its always worth the contribution to the cause…

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#130

Even cheaper and could be similar to you MRI sutff?
iherb.com/Source-Naturals-Nopal-Endurance-40-mg-30-Capsules/7753?at=0

#131

Eagerly waiting for some good results from the HSP approach.Best of luck!

#132

i am feeling really good right about now. EQ is at about 75% - 85% even REAL morning wood yesterday morning
im taking 300mg test-cyp per week
2 MRI HSP Active caps every 72hrs
20mg Nolvadex/day
5mg Cialis/day

plus a bunch of different types of vitamins, amino acids and digestive enzyme caps from the health food store

oh yeah and i am seeing a Psychologist now who specializes in behavior. he was talking to me about all sorts of shit where he was saying that your body loves habits for example typing without looking at the keyboard. your body has learned where to put your fingers when you need to type and he said that you can get trapped in learned behavior in every organ in your body including mechanisms at the endocrine level and once you can recognize that behavior you can change it and it takes 5 6 months or so. antoher thing he says he has done is he can hook up a device to your penis while you lay in bed you listen to you penis blood flow. and you hear more blood flow going into it by the noise the device makes. And when you hear blood flowing you can adjust and attempt to continue to try to duplicate teh sound and eventually after a few months you can control the entire behavior beyound what you would ever think possible… at any rate, i need to talk to someone about everything so its good to see someone who i can talk to who isnt just trying to give me antidepressants. im really happy I am going to him. he also made some recommendations to the local university research center and to Scripps Clinic for diagnostics

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#133

In a few days, when the temporary improvement you are experiencing ends, this sentence will sound silly even to you. Note that your improvement is certainly going to end, because nobody has recovered by messing with sex hormones. I still do not understand why you are convinced that you are the only one that can beat PFS by only messing around with T.

I don’t mean to be rude, but if you want to mess with your hormones, I think you should not waste your time with treatments that have never been successful. Instead, why don’t you try hormonal treatments that have been successful for somebody else? Although their success rate is not 100%, it is greater than 0%. For example, your cycles of temporary improvements sound a lot like the ones JN was having when he was taking on T+arimidex. He could dramatically improve his health only after addressing thyroid and cortisol issues. Why don’t you talk to your doctor and try to address these issues too – which you definitely have, given your symptoms?

#134

Hey M81 - I was simply quotuing what my psychologist was telling me about behvioral modification… I agree with you but my reverse T is in range now and I havent seen improvement with Hydocorisone and T3… as much as i want to… I agree that it seems to pararellel JNs ups and downs but I need to get a doc that wants to help me sort out cortisol and I cant even get one to test it

I notice that you wrote this over a week ago and I havent even looked at this website since then as opposed to several times a day without the testosterone. so the testosterone doesnt cure me or anything but it keeps the razor blades away from my wrists and me away from this website lol

#135

update:

so i fell off for a while and started searching desperately again.

i ran some ivermectin, flagyl, and nitrazoxinide per dosing instrcructions availble on drugs.com . back to back but not at the same time
then followed up with keflex which i am currently taking 500/mg 4xday
along with 200mg /testosterone /wk and 20mg of nolvadex/day

also i take a very strong probiotic and digestive enzymes and amino acid supplement

i have to say that i can get a THICK pulsing erection with the aid of cialias/and or viagra -

i think the biggest improvement i saw was after i took those things and started back up the keflex and then once i took my next testosterone shot everything got way better like my body was accepting more of the testosterone than usual . most notable improvement is in orgasm feeling and general good feeling in my genitals kind of a buzzing that has returned for now

still not perfect but in good shape better than i have been

i told my endo about my remarkable temporary improvement with keflex and he gave me a referral to a infectious disease specialist which i have an appt to see next week

1 Like
#136

Wow nice. How do you know it was keflex that helped so much? (Cuz you were on other things before/during)

The infectious disease specialist angle sounds intriguing. Personally i do alot of travelling to piss poor countries and with my weak immune system, exposure to flies, crappy water, etc, who knows if there’s something else going on. From my experience, the doctors in Asia love to prescribe Flagyl for many bacterial ailments.

Keep us informed!

#137

well i dont know that for sure, but timing wise that was when i felt better again.

rewind - i had an injury and i was in the ER where I was given IV antibiotics and a script for Keflex for 10 days after.

The day after my injury I woke up with an erection and the following day with no viagra such a hard morning wood i couldnt piss in the toilet! then each day it got a little worse and worse

A week later i had went and got more and it helped some but not too much and then i ran out as it was wearing off.

Then i fell off hard for a month and then something kinda weird happened again. My injury was that i pretty much cut off (like 3/4 of ) my finger surfing and they had to reattach it - basically reattach all the ligaments and tendon again. Now it is all swollen after it has healed there is no open wound there now all of the stiches were out and no infection. Then gradually my other 3 fingers (not the thumb) became inflamed and extremely painful. Turns out it was most likely an infection in my hand but with no open wound any more. I dont know for sure at all but just a theory that maybe whatever is causing this problem came out to the injury and continued to infect my hand. Anyway the doctor who saw me for my now infected hand (not just finger) wrote me keflex which i took and then saw the drastic improvement.

i feel like maybe the IV antibiotics were what really helped me and Keflex just doesnt cut it - like perhaps some sort of mild sepsis or something. I dunno

anyway i will keep everyone posted after my doc visit

#138

Your improvement could be due to the anti inflammatory effects of the anti biotics. I’m curious how you would react to prednisone or dexamethasone

#139

It would be great if others could try dexamethasone. We could get 5 guys to try it and report back to a thread for the experiment.

We could do this for other meds too.

#140

appt with the infectious disease specialist went okay…

he ordered tests for lupus and infections of the blood and i will report back when i get the results