Things I've tried so far

Therapeutic Efforts Pharmaceutical
#11

Short update about my condition:

I’ve had a 100 mcg triptorelin injection at February (my second one so far), and I now have better baseline total testosterone. Estradiol and SHBG remain about the same, which is a bit high, so I’m now using exemestane to lower those. I’ll have another triptorelin shot at the beginning of June. I’m also using vitamins, minerals and amino acids, and I do weight lifting every other day. I can have and keep a good erection if I don’t fap for 3 days or more.

Triptorelin injections are helping I think, when I first started treatment, my total T was 2.5 ng/ml. My latest test results are as follows:

Total Testosterone: 5.35 ng/ml
SHBG: 30 nmol/l
Estradiol: 34 pg/ml

I recommend genuine pharma grade 100 mcg triptorelin injections for anyone who wants to try treating hormones. You can have a shot once every 4 months, I wouldn’t recommend doing it more often, since it’s very strong and can be suppressive when done often.

#12

I’ve been taking half a tablet exemestane (12.5 mg), after 10 days my new test results are:

Total testosterone: 7.08 ng/ml (2.19-9.05)
SHBG: 26.67 nmol/l (13-71.7)
Estradiol: 24.8 pg/ml (<62)

These are the best levels I’ve ever had since I got PFS in 2009, 2 years ago my total T was 2.5 ng/ml, and estradiol and SHBG over 30. I should feel normal, or at least better, but I don’t. At least I’m no longer hypogonadal and I believe if I keep these levels or higher, after a while my body should recognize increased testosterone and heal. I’ll do another 100 mcg triptorelin shot at the beginning of June, which should improve my levels further.

#13

I had my 3rd triptorelin 100 mcg injection yesterday. I’ll do blood tests 1 month later, at the beginning of July. I’ll update if there are any changes in the meanwhile.

#14

I think we can conclude that PFS is not a standard issue with hormones. Too many take hormones improve their hormones a feel little better. Many of us have bad hormone levels but we just don’t know what is causing it and why hormones often seem blocked.

#15

I know, but still, bad hormone levels is part of the problem, and triptorelin has helped me so far in that regard. As I’ve said in my previous posts, my testosterone was borderline low when I was first diagnosed, and now I have a much better baseline after two injections (mid level). I’ve tried other things before (clomiphene, etc.) and the only thing that has given me better baseline is triptorelin. I’ll try to increase baseline to over 7 total T, and if I still don’t feel well I’ll look into other things than sex hormones.

#16

For me I injet 250mg of TRT and have 0 muscle gain and 0 libido… I do have low free T now.

#17

Well, triptorelin isn’t TRT. It’s very different than directly injecting testosterone into your body. Triptorelin is GnRH, which is the initial step in the hypothalamic–pituitary–gonadal axis. It tells your body to start producing all sex hormones, think of it as the top of the hormone chain, whereas testosterone is near the end of the chain.
en.wikipedia.org/wiki/Gonadotro … ng_hormone

#18

vanquish
hope you are aware that it will stop your T production
en.wikipedia.org/wiki/Triptorelin
During the treatment of prostate cancer it does cause a surge of testosterone (an initial uplevel of testosterone levels), known as a flare effect. In men a reduction of serum testosterone levels into the range normally seen after surgical castration occurs approximately two to four weeks after initiation of therapy

#19

It only stops T production IF you use Triptorelin pamoate (3.75 mg), which is the high dose depot version of the drug. The triptorelin I use is Triptorelin acetate, an extremely low dose (0.1 mg) of the drug which causes an increase in T production WITHOUT causing the chemical castration effect like the high dose of the drug. Have a look at this:
ncbi.nlm.nih.gov/pubmed/20416868

#20

I had new tests done today, 2 months since my last triptorelin injection. Results are:

Total testosterone: 4.15 ng/mL
Estradiol: 24.19 pg/ml
LH: 6.37 mIU/ml

Both estradiol and total t are lower than before. I don’t understand how the hell this could happen. It can’t be the suppressive effect of triptorelin, since LH isn’t lowered (high dose triptorelin suppresses LH production, which in turn lowers T).

I’m out of ideas now, I may do another 14 days water fast, but to be honest at this point I just want to end this life, it has become a complete torment for both my body and soul.

#21

I’m seeing a new urologist now, after finding out about him in the PFS foundation website. He gave me a papaverin injection to test my erection quality, he says my erection is down to %80 of normal. He told me that recovery from shrinkage is possible unless erection quality dropped below %60.

He gave me Arginmax (3 tablets 2 times a day) and 5 mg cialis everyday, 300,000 UI Vitamin D every month for 4 months. Also, he said he might give something to increase testosterone a little bit, very low dose clomiphene and aromatase inhibitor maybe. I’ve been using arginmax and cialis for 2 weeks, erections are much better, harder, bigger and lasts longer, close to normal.

I highly recommend using these to keep your penis healthy if you have ED or shrinkage, I think it’s a must and I wish I started using them before.

#22

When the urologist says that recovery from shrinkage is possible, what does he mean by that? How would you/he describe your shrinkage? Is it permanently smaller/thinner/shorter, or varies? I ask this as there seems to be varying accounts as to what shrinkage actually is. My own shrinkage appears to be tissue loss to the shaft, rather than something variable, and I would be both surprised and comforted if a urologist said that this is something I could recover.

#23

You can recover it, but only if PFS is cured/treated. If you havent recovered after many years, you need a medical intervention.

#24

He means that it is possible to increase penile cavernous capacity back to it’s original. He also said that since we don’t know which neuropeptide (there are like 3000) that finasteride effected, it’s not possible to actually cure PFS yet. The aim of this treatment is to keep the penis in healthy shape so that if one day a cure for PFS is found or the body heals by itself, I’d have a working dick.

The penile doppler I’ve had done a few months ago had shown some loss of cavernous capacity. My penis has a slight axial rotation to the right when flaccid. When erect, it’s softer, smaller and bendable upwards. It’s like the limit that it can be filled with blood has been lowered, even when I used high dose viagra/cialis/levitra. Also I have pain at the right side of my penis.

Two weeks after using arginmax, cialis and high dose vitamin D there is now a %5-10 more fullness, and when I ejaculate it shoots much farther than before.

#25

I spoke to my psychiatrist today, and he agreed to prescribe ECT to me. I have no idea if it could help with PFS symptoms, but I thought it’s worth a try since we know that finasteride effected our brains. ECT causes changes in the chemistry of the brain, and receptors in the brain. I haven’t decided yet if I should do it or not, I’d appreciate if people share their opinions on the matter, to help me decide. Here’s some info about ECT:

mayoclinic.org/tests-procedu … c-20014161

#26

i have sent a PM, vanquish.

#27

Update: I had stem cells and prp injected inside my penis one month ago, the doctors didn’t give any guarantees, and the stem cell doctor told me to contact him a month later and tell if I felt any better. There has been no changes, so I’ve sent him a message and he said they could inject stem cells intravenously or intrathecally, inside the spinal fluid, so that they can effect the brain.

I’ll have to stay at the hospital if I decide to have intrathecal injection, since it’s done like surgery. I haven’t decided yet, it takes a few weeks till they prepare the stem cells, but I think intrathecal injection seems like the better option, since the few studies published about PFS point out to a problem with the brain and central nervous system.

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#28

Vanquish, I hope you have not tried ECT. It is the worst thing you can do as it will destroy your brain. If you have, please come back to say you are OK.

#29

I did, and I’ve felt terrible for a while. I’m fine now, like pre-ECT (still got PFS though).

#30

Merhaba bende turkum norvecte yasiyorum yaklasik 9 ay kullandim bu ilaci birakali 17 ay oldu malesef ayni sorunlar bende de var sertlesmeyi tam sagliyamiyorum kismi iktidarsizlik var testestoron seviyeme baktirdim burda hersey normal cikti bir de detayli baktircam cialis 5 mg kullandim ama yeterli seviyeye getirmiyor dusunerek bile eriksiyon haline getiriyorum ama koruyamiyorum kendimi fazla odaklayamiyorum turkiyeye gelince bende muayene olacam bana ønerileriniz var mi?

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