yikes, this thread has taken a bit of a detour …
Let’s get back on track:
J Med Microbiol. 2000 Sep;49(9):831-40.
[Size=4]Antifungal activity of ibuprofen alone and in combination with fluconazole against Candida species.[/size]
Pina-Vaz C, Sansonetty F, Rodrigues AG, Martinez-De-Oliveira J, Fonseca AF, Mårdh PA.
Department of Microbiology, Porto School of Medicine, University of Porto, Portugal. micfam@ip.pt
Abstract
Ibuprofen, a non-steroidal anti-inflammatory drug, exhibited antimicrobial activity against Candida albicans and non-albicans strains. At 10 mg/ml, ibuprofen showed a rapid cidal activity against exponential growth phase C. albicans, accompanied by rapid and extensive leakage of intracellular K+, permeation to propidium iodide, lysis of spheroplasts and severe membrane ultrastructural alterations. These results indicate that the killing of Candida cells is due to direct damage to the cytoplasmic membrane. At 5 mg/ml, ibuprofen inhibited growth; however, it did not kill the yeasts and did not directly affect the cytoplasmic membrane. Evaluation of yeast metabolic vitality with the fluorescent probe FUN-1 showed that growth inhibition induced by the fungistatic drug concentration was due to metabolic alterations. The combination of ibuprofen with fluconazole resulted in synergic activity with eight of the 12 Candida strains studied, including four of the five fluconazole-resistant strains. The MICs of fluconazole for the fluconazole-resistant strains decreased 2-128-fold when the drug was associated with ibuprofen. When in combination with fluconazole, MICs for ibuprofen decreased by up to 64-fold for all the 12 strains studied. These results point to the practicability of using ibuprofen, alone or in combination with azoles, in the treatment of candidosis, particularly when applied topically, taking advantage of the drug’s antifungal and anti-inflammatory properties.
NSAIDs are hard on the stomach, though. Just an option to consider. IHP did warn that Fluconazole is powerful, fatiguing stuff and he cycled it a few times a month to minimize liver damage. Still seems as if Nystatin / Intestinal action was the biggest contributor, until the final “flushing” phase of IHP’s recovery.
So, everybody on this site believes MEW is involved in a conspiracy to make money??? Give me a break. Its one thing to disagree with theories/opinions…even if it is with MEW or AWOR or anybody else (I have had a a few differences of opinion with MEW over on the kos thread). But you just cannot launch unfounded attacks like that. Not only is it downright disrespectful, but such silly accusations could have wider implications when we consider the type of lurkers we have on this forum.
What AWOR/MEW et al have done with their latest research attempts is pretty miraculous. I just dont understand how so many of you cant sit and wait for the results to some out. Just wait!!!It wont be that long before we hear big news and take another big step. For the record, I believe we have autoimmune problems, prostatitis and all other sorts of gut, fungus or whatever else. But the from first day I took fin and my dick went numb…THE VERY FIRST DAY…I want to know what happened :The cause…the root of all of our symptoms. Nobody will come closer to discovering that than AWOR/MEW et al.
Chill, bro
No I wont fucking chill. People need to get checked.
we are all human…even in a situation like this…people say hurtfull stuff to others sometimes ok? so lets get back to the thread’s subject ,shall we?
Seanyboy, just want to make clear that I do not believe Mew or Awor have money making motives. No way. I believe they are doing their best to decode this PFS problem.
That said, they are beholden to certain theories, often to the exclusion of others, for various reasons, such as (i) the alternate theory is quackery, (ii) the pursuit of the alternate theory somehow derails their efforts in support of their theory; (iii) observers of this website may mock the alternate theories and thus discredit PFS in general.
My only gripe is, why the extremely dismissive attitude toward alternate theories? It’s not like the dominant theory has resulted in a number of recoveries. Until someone figures this out, we should be open minded to all possibilities. That’s all I’m gonna say on this.
Back to IHP.
Mew can express his opinions all he wants. Just because he is the key figure doesnt mean he has to be tread on eggshells around what other people think. He likes to be upfront and to-the-point. I have no other reason to talk like this than out of respect for the guy. The lot of us have been told that something has been found, and to sit tight and wait for further news. Instead, people are still happy to launch mindless attacks on someone who has been very instrumental in making this research happen.
Whatever dude. I’m sick of people claiming everything to be quackery and bullshit when people with PFS were helped by more holistic approaches to this problem. It’s putting people off from finding relief when they may be going down a horrible downward spiral in PFS. I want people to get better and every time people claim these more holistic approaches are quackery and the only option we have is to take random pills that could get people WORSE, it PISSES ME OFF.
What I said is just knowledge and I said if he WANTED TO HE COULD NOT THAT HE WAS DOING IT
I am apologizing because I realize my wording was extremely insensitive considering the countless work he has done for the problem. I had the wrong wording that inferred people that he WAS doing it and it was a mistake in my anger over this consistent trend I see.
If we do not work together, it is hard to move forward. I am frustrated as the next guy, I have not slept in fucking days, DAYS!!! Still, we need to be a team and not fight each other. If we do not have each other, we are toast. It is us against the world at this point. Be at peace with each other, this arguing just doesn’t get us anywhere. I say these things with respect and love for all of you. Come on people.
i think inflammation is more plausible than androgen receptor damage because 1 if our body doesn’t feel androgens anymore why hair keep on falling? 2 when i took hcg and i had testosterone much higher than the normality range i felt every single molecule of testosterone in my body, before having blood tests done i was sure my testosterone was over the limit and effectively it was . 3 cialis doesn’t work if there is nerve damage downthere while it should work with hormonal problems and for lots of us cialis is almost useless. 4 generally when something in our body is inconstant it is due to inflammation, if androgen receptor is damaged it should be damaged every day at the same level whilst inflammation could be more intense today than tomorrow, it explains better why my/our sexual situation is so changeable.
Yes, but the inflammation could be a result of genetic changes which affected the Immune system.
Getting out of topic here but if we have chronic inflammation of auto-immune origins, LDN (low dose naltrexone) and NORMAST (that tim posted about) are promising treatments (if not cures). I plan to try them (I have, after all, chronic abacterial prostatitis)
Joetz had used Low Dose Naltrexone in the past. He may have some interesting information for you if you like.
candida has been on topic…since 2007 wowww and only now the pieces are getting together…
and so? i compared inflammation in pelvic area that affects pelvic nerves too and androgen receptor damage.
a very stupid question, if we suffer from inflammation in the whole pelvic area can taking anti-inflammatory have a good effect on our symptoms or there are some strange reasons that prevent anti inflammatory from having effect? because if i take anti-inflammatory and i’ll feel better i’ll be sure about the origin of my problems, does it make sense?
Well inflammation can be infection or auto-immune based. And antiinflammatories can have other little known properties, ie ibuprofen is also a potent antifungal, so…
(many ppl have reported improvement with ibuprofen here)
We hear of so many people saying they have appointments with their doctor for xyz in many of these inflammation threads. Can someone point me to some links where people have been diagnosed with inflammation/autoimmune problems other than prostatitis?
My CRP (inflammation marker) is VERY low, and my ANA (anti nuclear antibodies, marker for autoimmune diseases) are very low too… But I do have chronic prostatitis (like I said, greatly increased leucocytes in post-prostatic massage urine, painful DRE with slightly swollen prostate, TRUS with doppler reveals inflammatory spot in the left lobe, the painful one, and increased vascularization, meaning inflammation. But size of the gland is normal. All of this does not come from Dr G btw). Problem is no biological marker is 100% reliable in medicine…
I wonder what JN would say about all this? Just curious.