I dont know what study your talking about, please post it. However, i do know this:
• Prof Traish has published two peer reviewed academic papers on Finasteride side effects, he NEVER mentions any problems with the androgen receptor or anything similar as being the root cause of the sides.
• Men undergoe full androgen ablation when they have prostate cancer, they DO NOT suffer from ‘PFS’ after stopping.
• Dr Irwig, Dr Goldstein, Prof Traish et al have all published papers about finasteride side effects, it is OBVIOUS they all think it is caused by neurosteroids being inhibited.
• All of the academics I mention will be aware of Awor’s theories (who has said himself that his ‘theory’ is all about a post-AR-receptor problem anyway).
Hello Oscar, have you read, what I wrote? I dont want to discus with you. I offerd you some help and you are ignoring it also. All that counts for you is to fight against something. You even dont care much about what you think about your theore, I dont spent my time to show the world why your theory ist wrong. All you are doing is finding proves why you think it is wrong. This makes you very very doubtfull for me and I think also for others. I can not post you the unpubl. Data of the PFS studie. sadly we all need to wait for it. Anyway it has been mention from others before.
“In this subset of finasteride users, 5-ARI may lead to diminished synthesis of critical centrally-acting neurosteroids, and/or increased synthesis of androgen receptor with subsequent androgen receptor insensitivity” onlinelibrary.wiley.com/doi/10.1 … 4/issuetoc
So,
-Why do you ignore, when someone offer you help?
-Why are you sending so much time to show that something is wrong. Someone who works on something, dont waste his time to show that what others doing is wrong, they work on thier owen projekt.
I wrote you this many many times. DO something and not only waste your time. Answering you such Posts is the worst waste of time I can image, cause they lead to nothing productiv. You repat and repat the same useless arguments, even when they are wrong. Studies has been done on the AR and something has been found now we have to wait for the publication…beside you can do other things, like I do. All those discussions are a waste of time.
You keep peddling this nonsense. Spend fifteen minutes googling permanent side effects from Lupron and Zoladex and there are many examples of men who don’t recover from the symptoms of having zero testosterone. Granted, they don’t make as much noise as we try to but then they are mostly in their 60s to 80s and took it to avoid DEATH.
Unless you think that because there have been no official studies of it, it doesn’t exist. Because by that rationale PFS has only existed for one year.
I do not understand Oscars goal with all of this myself, and it seems his reasoning is shoddy at best. But guys, you do not need to defend yourselves or our research initiatives to him. If he feels the need to stir things up on a regular basis, and as long as he has regular posting privelages, he will continue to do so. If for some crazy reason, someone wants to put their trust in him and his theories, that is unfortunate, but that is their problem.
our PROFESSIONAL SCIENCE RESEARCH team knows what they are doing !!!
Guys, Oscar is right we need to explore other avenues of treatment/research. With regard to the silenced androgen receptor, traish, Goldstein, and even Jacobs don’t really feel its androgen resistance or partial androgen resistance. The fact remains that finasteride has been studied for years and we know what it can do. I encourage everyone to read a paper by Deborah A Finn entitled “a new look at the 5ar inhibitor finasteride” There is a massive neurological component to this which seemingly effects certain CNS parasympathetic and sympathetic responses.
creating awareness and discussing this syndrome in depth with as many medical professionals as possible is perfectly fine, but knocking existing research is nothing short of retarded, and that is the point being made.
This thread is about Testosterone, dihydrotestosterone or 5ar2 antibodies and not about Neurosteroids, but anyway…when you look back, before your puberty, you had normal levels of Neurosteroids did you had beard? Do you think neurosteroids will let your body hair grow?
Mew, when I saw him this summer, he brushed this theory off. His own preferred method of treatment of super high doses of TRT is even counter to the silenced AR belief. I think Jacobs is an extremely academic thinker and this was just one of his initial theories. Again, I am just going on what he told me in June.
First time I fully agree! Guys, please keep this thread on the topic. It is about Testosterone, dihydrotestosterone or 5ar2 antibodies. Not Neurosteroids
I have a question about testosterone and androgen insensitivity. Last week I couldnt get a sexual thought in my head, what has been coined the “no penis to brain sensation” When I did manage to orgasm I couldnt feel anything, also had extreme numbness downstairs. I had elevated depression, brain fog, and bi-lateral pelvic pain.
sooo, on Friday night I decided to drink as many vodka soda’s as I could. Got absolutely wasted. Woke up Saturday with an erection and very horny. That kicked off the last 5 days of better orgasms, more sexual thoughts, stronger erections, less brainfog, less depression, nocturnals, etc.
Tim, I am asking about T and DHT in so far as his they may have been affected by alcohol. I am asking if anyone can explain the sudden turn around I had. Now I can explain it somewhat with neurosteroids, but I was looking for possible reasons here. Could alcohol have raised my testosterone or dht levels?
I would like to correct the above post: I did not take Finasteride because I was losing my hair. It was prescribed because the TRT raised my DHT to an extremely high level. The Finasteride was prescribed prophylactically to prevent prostate problems.
Frankly, I’ve never been inclined to use any topical or systemic substance for hair-loss. Interestingly, the thinning of my hair ceased after I was treated by an Ayurvedic physician prior to starting TRT. (I wasn’t being treated specifically for hair-loss.) That was over seven years ago and not only haven’t I lost any more hair, I’ve experienced some regrowth along the lines of descriptions I have read by men using Rogaine.
tim1911 or any body if you can find and go for Androgen receptors anti bodies or 5AR antibodies, please contact me with detail of the tests etc. I am ready to share upto 50% of the cost for these tests. PM me for all the detail.
