St. John’s Wort (Positive Experience)

Any new information about your expirement with this herb?..I have bought a bottle, and will be using it soon…Only thing that makes me scared is the fact, that im taking Wellbutrin+Mirtazapin (Plz dont tell me to stop using those, cuz they literally saved my life, i would have killed myself months ago)…Im really scared of triggering a serotonin-syndrom, which can be fatal, but again i have 6 months left to be living in this hell before i decide if life without any joy is worth living ot not…

Thanks for sharing your experience. As this study posted earlier in the thread suggests, SJW could interact negatively with PFS patients becuase of its possible 5ari properties

https://www.ncbi.nlm.nih.gov/pubmed/16261523.

Short term administration of SJW does not significantly alter the concentrations of most circulating androgens in men and women but may produce a dimunition in some of the circulating 5alpha-reduced androgens.

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I am on day 31 and have seen many positive reactions so far have had morning wood most days, had a few days with spontaneous erections, had one strong erection last close to an hour with no stimulation, started having dreams again, and had close to normal sex with out cialis. All of those things hadn’t happened in almost 5 years.

Anyone else tried this? What are the experiences?

I gave up because SJW causes cataracts

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Anyone else tried this supplement? I heard negative experiences too, so im scared to try. I found it in my herbal tea as an ingredient.

I bought some

I’ve been having a tough last three months with anhedonia coming back

I started it today

So far no change in how I feel

I’ve been reading this a while before joining (see my intro thread) and on a brief look am intrigued that both the poster here and this guy in the link below were using the Hypericin form. Albeit he has declared success very early on.

This article this suggests this is a Dopamine reuptake inhibitor whereas the Hyperforin form blocks Serotonin, Gaba etc too.

IF this is correct, maybe Hypericin form of SJW rebalances things in some way? Others will have a much more informed view.

Also interested that this article suggests that this form can block Norepinephrine and Epinephrine - which are transmitters for the Sympathetic nervous system (fight or flight) in which low libido and elevated cortisol (which I generally have been stuck in since taking Finasteride) are common. This can also cause wakefulness.

Apparently these two suppress testosterone too.

I presume the cataract risk can be mitigated, builds up over time and tbh cataracts are very easily removed but correct me if I’m wrong.

It’s just interesting a few things line up here.

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@joetz How are you doing so far?

Just ordered the same SJW and will be trying this soon

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For those interested I might try ordering this

As it says it’s specifically made for low hyperforin. The guy on the Ray Peat board mentioned ZE117

I haven’t heard of or used this vendor though so can’t yet attest to reliability

I haven’t got it yet but presume it must be.

The thing I’m unsure about is how this all works with receptors as people say our dopamine receptors may be downregulated and SJW is just blocking them taking up dopamine?

Does this mean it will either work initially or risk further sensitivity/down regulation if it’s stopped…I don’t know the answer to this but will try it as I feel I have more to gain than lose on that side of things

Separately I tried tyrosine which is meant to increase dopamine and felt no difference at all

Just to update here, the Hypericin improved some sexual sensations for me but it gave me quite a lot of night-time wakeups. So I stopped.

As posted elsewhere I’ve used other things recently that have helped sleep a lot but they make no difference on the libido side.

I’ve found some conflicting research about Hypericin vs Hyperforin so may try the latter.

I think if you don’t have sleep issues this is probably going to be better for you than it is for me. It could also help if you have brain fog but no sleep issues as I think this did raise my noneepinephrine (as this causes wakefulness) and a deficit of that apparently causes brain fog (which I haven’t had to date).

Anyone got any updates???

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I guess I have to make my own updates, just bought the supplemnt and I’m gonna take it for a week. I WILL keep you updated.

I gave an update above your post

Yeah but you’re not the only one that has tried it. A lot of people try things and don’t share their experience. Which is a big shame in my opinion.

I had a colitis flare up that I needed to handle and just started it about 12 hours ago. I took 2 1000mg pills at the same time so it was a total 2000mg at the same time

Maybe I should space it out…not sure that was smart

Anyway here is what happened

First few hours really vivid dream, nocturnal erections and all kinds of goodness

I felt almost normal

Then I woke up and honestly I’m feeling quite a bit of side effects. Still have dry mouth, head feels kind of weird. I have had a hard time working up an appetite for anything. So it’s kind of rough coming down from this thing.

Maybe the rough side effects go away in time or maybe I’m just taking this thing wrong and should space out the doses. I’ll keep at it and hopefully I’ll see the benefits without the “hit by a train” side effects afterwards

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You cut off there? Which brand btw?

I just edited my post. Not sure where I was going there. I am taking a brand called “deal”

I don’t think the brand is the issue. I think that I took 2000 mg at once and that might be too much. My question for the people taking it successfully is how many mg are you taking per day? I want to stay with it and give it a chance but the side effects were absolutely brutal for me

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