A few more updates:
I’m having a terribly hard time finding labs that can check either my blood, plasma, or urine for Dutasteride. I’ve only found 1 or 2 that detect Finasteride in the blood plasma, but I’m trying to find one that will detect Dutasteride. I’ve contacted like 10-12 labs so far, including some of the biggest in the country. One lab said that they might be able to “build a test” for it, but it’ll be very expensive.
Accutante/Isotretinoin Molecular Weight 300.435 (small enough to pass through blood-brain barrier) and lipophilic (dissolves in fat).
Spironolactone Molecular Weight 416.57 (small enough to pass blood-brain barrier) and also lipophilic (dissolves in fat).
“Research has also shown spironolactone can interfere with the effectiveness of antidepressant treatment. The drug is actually (among its other receptor interactions) a mineralocorticoid (MR) antagonist, and has been found to reduce the effectiveness of antidepressant drugs in the treatment of major depression, it is presumed, by interfering with normalization of the hypothalamic-pituitary-adrenal axis in patients receiving antidepressant therapy”
----from en.wikipedia.org/wiki/Spironolactone -3rd paragraph under “Adverse Effects and Interactions”
Of the short list of people that are listed under the recoveries section, the users below somewhere in the post mentioned working out and eating healthier. Note that eating healthier also notes reduced caloric intake which likely means burning fat.
japanther - raw food diet, exercise
Big Softie - working out and healthier lifestyle, plus random supplements
HT55 - working out a lot, but also used nolvadex, hcg, and clomid
Mitch - worked out and ate healthier food
Tom43 - posted by user boston - walking, eating healthy, gaba, htp, and other supplements
ithappens - athlete, took GABAprentin and got better due to improved sleep… wondering if working out had an effect… not likely though as he felt immediate results from GABAprentin
Guru20 - took roughly 2 years to get better, worked out 3-4 hours per week also took Green Tea (no coffee), GABA and DIM supplements, was working out both when he was healthy and when he got sick
MLevyHolden - worked out everyday, ate healthier, MACA extract and TRIBULUS TERRESTRIS
Reason - tried all different things and supplements including zinc, viagra, broccoli and veggies, eating healthier, all sorts of exercises: punching bag, swimming
Many substances either increase CYP3A4 function (inducers), and many things lower CYP3A4 function (inhibitors):
en.wikipedia.org/wiki/CYP3A4 - check bottom of page for a list of them.
Ketoconazole, a strong inhibitor of CYP3A4 function, is a drug/shampoo that many hair-loss suffers use to help prevent hair loss. I myself have applied this shampoo (2% variation) to my scalp for 10-15 minutes every time I shampooed and also noticed some side effects from it like dry eyes and a weird taste in my mouth (alkaline?). This study shows its effects on a drug’s absorption levels:
resources.metapress.com/pdf-preview.axd?code=r307129371lg0066&size=largest
Also, a lot of other drugs like antibiotics such as z-pack can also interfere with the function of CYP3A4. I also read that some men just have different amounts of CYP3A4 in their body, some with less, others with more. This might account for what happened to us. Either that or we really screwed up our CYP3A4 synthesis. Also, on the wikipedia link, there is this line that states that CYP3A4 is also found in the brain?!?
One thing that’s an inducer is Saint John’s Wart. I’m thinking of taking it to see if it allows me to do more running with less estrogen dominance as it will reduce the amount of DHT being inhibited by Dutasteride which I believe will flow into my blood if I do a lot of running.
I hope all the randomness in this post makes sense.
I’m trying to keep up the spirit you know. I might have crashed nastily but might as well drop dead if i give up with this or keep going with this, especially considering how my low testo and adrenal fatigue will eventually make my life much worse.