Ok i did a 6 day treatment using the demethylating agent lidocaine whilst subsequently reducing AR via the use of green tea, milk thistle, soy, selenium, oligonol, antihistamine, sulforaphane and quercetin. I initially included curcumin as well but i felt this had more negative effects.
I took the androgen receptor reducing agents for 2 days before starting lidocaine and it pretty much as anticipated induced a crash. I speculate that an overexpressed AR is giving us what little function we have so reducing it would precipitate a crash.
I then took lidocaine in an increasing dose intravenously under supervision (15min readings of BP,pulse, ECG). During which i noted similar feelings i get to when i increase testosterone - mainly an uncomfortable feeling around the eyes. As i increased the dose this feeling became more pronounced. Awor and procaine had a similar reaction and initially worsened on it. He thought perhaps this was due to a reduction in hypersensitivity leading to a feedback effect causing more LH and FSH to be produced increasing testosterone leading to downregulation of the mechanisms past the receptor.
Now after therapy which ended a week ago i continued to take AR reducing agents which still make me feel not so good. I have not had visible improvements.
One thing to note is that by reducing AR i nearly completely remove all prostatic pains and numbness. However, function deteriorates with it.
My next plan is to continue reducing AR but also try and alter the downregulated mechanisms. Now i don’t know the mechanism and only research can tell us but for now i am going to assume that p300 is a good candidate to mess with for the reasons below. Now this is one of many things that could be affected so this is very much a guess. But my reasons are:
p300 activates via its HAT activity about 40% of ARGs. It does not activate the AR gene as keep in mind the AR gene is an androgen responsive gene. Therefore if it is downregulated it makes sense that AR is not.
p300 is upregulated in times of androgen deprivation to maintain things.
p300 is downregulated by testosterone. This explains why to me that testosterone supplementation (or increasing it like i did via tribulus and resveratrol) improves somethings in myself and worsens other things. The other 60% are driven whilst 40% are shut up even more.
p300 is upregulated by dexamethasone and sepsis. A few cases of acute ill health have told stories of temporary recoveries. A few people have had success on dexamethasone. As it is a nuclear co-activator it interacts with glucocorticoids and thyroid hormone. Therefore by increasing these it might be possible to increase expression. In fact benefits from long term low dose of these two might affect us.
p300 is modulated by retinoic acid. Remember tryingnottoworry had a complete recovery on spinach of all things! Now he believed his dolichol hypothesis but that doesn’t carry much weight in my opinion now. I believe his story to be genuine and spinach is full of vitamin A. Vitamin A can modulate p300 activity.
Personal trials of Ar reducing agents and p300 reducing agents. For example whenever i get downregulation of whatever it is downstream i get this strange feeling between my eyes. I got it when i took tribulus, when i took resveratrol and when i took curcumin. Curcumin downregulates AR but it also downregulates p300. Resveratrol downregulates p300 and testosterone does too. I do not get that feeling if i take other AR reducing agents. Coincidence?
The problem if this is true is that if we reduce AR - most of the things also seem to reduce p300. If we upregulate p300 an overexpressed AR would potentially shut its expression off again. So we need to concurrently find a way to downregulate AR whilst upregulating p300.
Now depending on severity of downregulation one agent such as dexamethasone might not be enough to sort things out. Maybe by combining them one has a chance. Mitch used armour thyroid, and isocort and improved eventually. Cytochrome had one recovery via Dexamethasone but then it didn’t work the second time. Dury had some success with synthyroid. Tryingnottoworry and his spinach experiment. Also other stories of temporary recoveries in times of illness, in times of using tyrosine and iodine lend a little credence to this.
I don’t know if this idea is true but i’m going to test it out.