Hi Brainbug. Glad you have been thinking about things and reached the same conclusions as me.
Truth is nobody should pretend they are an expert in epigenetics. However I would add; 5) the fact is ‘PFS’ has never been recorded in 50yrs of intensive study of androgens and androgen receptors.
I think we CAN be insensitive to androgens, not in the way awor describes, but due to a pre-receptor problem;
1.) We know during the ‘crash’ LH and T goes down. Therefore a. the receptors in the pituitary are down-regulated (or b. its tertiary hypogonadism.) No other mechanisms behind this phenomena has ever been recorded in scientific texts.
2.) If the ‘damage is done’ no amount of T will help. But this is clearly an issue with androgens when TRT rebuilds muscles but makes sexual problems worse (me, 40 etc). This also more clearly points to downregulation in DHT/5aR sensitive areas. This also points to muscle loss occuring due to low biologically available T.
3.) Hairloss, body hair growth is also driven by androgens. Its possible for something effecting a receptor to have different effects at different tissue.
4.) He doesnt know the answers. It would be good if one of his scientists could answer these points!!!.