19 - Are demethylating agent usually only good against certain target genes that have been turned off, or are they usually broad spectrum? The only demethylation I’ve been doing is decaffinated green tea each day. The EGCG in it is a known demethylator. One of the recovery threads (can’t remember who right now) claimed he got better with green tea and DIM.
Most are broad. Green tea is too.
Think I might have to stop disulfiram due to peripheral neuropathy.
Quite annoyed i have to stop disulfiram. Taken it for 5 days but not taking today as peripheral neuropathy - losing sensation in hands and feet. Should come back. Its not a permanent thing according to the literature as long as you stop.
If anyone else wants to give it a go and let us know if you feel any different would be good. It also does stops dopamine breaking down so increases dopamine levels.
Ok so I had no luck with disulfiram. Was on it 5 days - did nothing but give me a peripheral neuropathy which i have recovered from in full. Don’t think its demethylating effect was strong enough and the literature agrees with me.
So at the moment that only really leaves procaine, and azacitadine.
The side effects of the latter are:
Azacitidine appears to be well tolerated, with the most com- mon grade 3 or 4 events being peripheral blood cytopenias.6 Injection site complications are the most common treatment- related non-hematological complications in subcutaneous azacitidine dosing, followed by nausea and vomiting. Although sometimes severe, myelosuppression is usually tran- sient, with most patients recovering before their next treatment or usually managed with dosing delays (23%–29%).
The highest proportion of adverse events occurs during the first two cycles, and the drug’s tolerability improves sub- sequently. The infection rates were not statistically different when comparing with basic support (RR = 1.00 [95% CI: 0.81, 1.22], P = 1.00]. The administration-related events such as nausea and vomiting occurred typically in the first week of drug delivery, resolved with antiemetics during the studies. The majority of injection site complications are typically mild erythema, and most improve after the application of warm or cold compresses to the affected area for a couple of hours.
IF DNA methylation is the issue this is at the moment probably our only hope.
Also found a place that does procaine i.v.
aeskulap-klinik.ch/index.php?option=com_content&view=article&id=392&Itemid=433&lang=en
What they give it for is nonsense but they at least do it.
You still think this will work even though Awor didn’t have success? I know this is different, but I injected about 6 cc’s daily per Shippen with no results either. I still have a ton of procaine sittin in my fridge. I think your reasoning is sound with what we know at this time. Obviously this is all a shot in the dark until we can get the interest of a research lab.
I.V. procaine is the only procaine option that could work. Injecting will do nothing due to its half life apart from give a placebo effect.
Now awor had success at first especially mentally. Over time it did wear off but maybe also with repeated treatments the effect will become more pronounced. Also it takes about 72 hrs before demethylation takes place. Awor had a shorter treatment. So short treatments will only start the process. Also remethlyation is a problem which it is possible is what awor experienced.
You need to hit it hard to get results. Having said that the degree of silencing is likely to vary in all of us so different people will need different depths of treatment. So its worth a shot.
Even if there is only a minor improvement it will show promise!
Another member here is having methylation testing done. That should tell us something. I think his results are due back in a few weeks. Would love to see a sample of 20 or so of us have testing done.
where is Awor? I hope he would come out with some happy news.
Does anyone else find it worrisome regarding how long he’s been away (Awor, I mean)? I hope he is OK.
Awor’s last login was March 24th, At least we know he didn’t jump off a bridge or anything. I’ve been wondering how he’s been doing too. Kinda disappointing that he hasn’t had much to say recently, most of his posts are very interesting/relevant.
Good luck with whatever you’re doing awor.
Ditto.
Where did he have the methylation testing done? What did it cost? I think many of us would like to have this done but we don’t know how.
Ask Frustrated. Seems to be through Dr Jacobs.
Said those labs will take a few months. Hopefully will hear something soon. Technically I think his father ordered the lab as either a result of his own research or per discussions w/Jacobs or both. Anyway, those of us who are patients of Jacobs I would think the results will play a big role in future treatment options.
Just to clarify, a family friend offered to run some methylation tests after she briefly learned about my condition. The doctor has been extremely busy and the tests are complex so it is going to take a while to get results. There is a chance that the tests are never executed so I probably shouldn’t have mentioned this so early on. To my knowledge, this type of assessment is not currently available commercially. I’ll try to keep pressure on the situation, but I don’t really have much control over the situation. I’ve been instructed to keep my expectations low for these tests and I apologize if I prematurely got you guys excited.
The doctor currently has my blood sample that may be used to test for methylation. It might make more sense to draw a tissue biopsy to check the androgen reception in the related organs.
Recent article discussing finasteride inducing hypersensitivity of the androgen receptor during treatment.
Finasteride upregulates expression of androgen receptor in hyperplastic prostate and LNCaP cells: Implications for chemoprevention of prostate cancer
RESULTS
Immunohistochemical study revealed significant upregulation of ARs by finasteride treatment for 30–180 days. In cell line study, quantitative real-time reverse transcription polymerase chain reaction revealed significant upregulation of ARs treated by finasteride.
Very interesting and very relevant. Good find mariobros. Hope all is well with you.
Frustrated, i think you should really push for these tests to be done, this could be the key to finding out what is actually going on inside us.
Tell your friend how important this could be for thousands of men out there, and how many lives they may help if this testing reveals something.